An inexpensive, manually operated, solid-phase, parallel synthesizer

Aldrichimica Acta

Volumn 37, Issue 1, 2004, Pages 2-

  Vig, Balvinder S ^a,b   Aldrich, Jane V ^a,c  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INERT GAS; PEPTIDE; POLYETHYLENE; PROTEIN; RESIN; SOLVENT;

ARTICLE; AUTOMATION; CHEMICAL REACTION; COST BENEFIT ANALYSIS; DEVICE; DRAIN; EQUIPMENT DESIGN; INSTRUMENTATION; LABORATORY; METHODOLOGY; MOLECULE; PROTEIN SYNTHESIS; REACTION ANALYSIS; SOLID; SOLID PHASE EXTRACTION; SYNTHESIS;

EID: 2942735425     PISSN: 00025100     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. For a review, see Solid-Phase Synthesis, A Practical Guide; Kates, S. A., Albericio, F., Eds.; Marcel Dekker, Inc.: New York, 2000.
2. Gorman, J. J. Anal. Biochem. 1984, 136, 397.
3. Stewart, J. M.; Young, J. D. Solid Phase Peptide Synthesis, 2nd ed.; Pierce Chemical Co.: Rockford, IL, 1984.
4. Knapp, D. R.; Oatis, J. E., Jr.; Papac, D. I. Int. J. Pept. Protein Res. 1993, 42, 259. This report describes a similar albeit less practical synthesizer, and gives a brief history of systems devised to carry out parallel syntheses of peptides.
5. Bennett, M. A.; Murray, T. F.; Aldrich, J. V. J. Med. Chem. 2002, 45, 5617.
6. Vig, B. S.; Murray, T. F.; Aldrich, J. V. J. Med. Chem. 2003, 46, 1279.
7. For example, the Bohdan MiniBlock® system, which is convenient to use, is roughly 14 times more expensive than the system described here ($3,500 vs $250).
8. CHOIR = Cheap Homemade Organic Inline Reactor.
9. Vig, B. S.; Aldrich, J. V. Strategies for the Synthesis of Novel Head-to-Side Chain Cyclic Peptides: Application to Dynorphin A Analogs. In Peptides: The Wave of the Future; Lebl, M., Houghten, R. A., Eds.; American Peptide Society: San Diego, CA, 2001; pp 144-145.
10. Vig, B. S.; Murray, T. F.; Aldrich, J. V. J. Med. Chem. 2004, 47, 446.
11. Vig, B. S.; Murray, T. F.; Aldrich, J. V. Biopolymers 2004, in press.