-
1
-
-
0015237292
-
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
-
Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature 1971; 231: 232-5.
-
(1971)
Nature
, vol.231
, pp. 232-235
-
-
Vane, J.R.1
-
2
-
-
0015237275
-
Aspirin selectively inhibits prostaglandin production in human platelets
-
Smith JH, Willis AL. Aspirin selectively inhibits prostaglandin production in human platelets. Nature 1971; 231: 235-7.
-
(1971)
Nature
, vol.231
, pp. 235-237
-
-
Smith, J.H.1
Willis, A.L.2
-
3
-
-
0015237263
-
Indomethacin and aspirin abolish prostaglandin release from spleen
-
Ferreira SH, Moncada S, Vane JR. Indomethacin and aspirin abolish prostaglandin release from spleen. Nature 1971; 231: 237-9.
-
(1971)
Nature
, vol.231
, pp. 237-239
-
-
Ferreira, S.H.1
Moncada, S.2
Vane, J.R.3
-
4
-
-
0012432753
-
Pain and inflammatory mediators
-
Ferreira SH and Vane JR, eds. Springer Verlag, Berlin, Heidelberg, New York
-
Moncada S, Ferreira SH, Vane JR. Pain and inflammatory mediators. In Ferreira SH and Vane JR, eds. Handbook of Experimental Pharmacology, Springer Verlag, Berlin, Heidelberg, New York, 1978, Vol. 50, pp. 588-616.
-
(1978)
Handbook of Experimental Pharmacology
, vol.50
, pp. 588-616
-
-
Moncada, S.1
Ferreira, S.H.2
Vane, J.R.3
-
5
-
-
0016748441
-
Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides
-
Hamberg M, Svensson J, Samuelsson B. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA, 1975; 72: 2994-8.
-
(1975)
Proc Natl Acad Sci USA
, vol.72
, pp. 2994-2998
-
-
Hamberg, M.1
Svensson, J.2
Samuelsson, B.3
-
7
-
-
0017094798
-
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
-
Moncada S, Gryglewski RJ, Bunting S, Vane JR. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature (Lond.) 1976; 263: 663-5.
-
(1976)
Nature (Lond.)
, vol.263
, pp. 663-665
-
-
Moncada, S.1
Gryglewski, R.J.2
Bunting, S.3
Vane, J.R.4
-
8
-
-
0024425993
-
Aspirin and human platelets: From clinical trials to acetylation of cyclo-oxygenase and back
-
Patrono C. Aspirin and human platelets: from clinical trials to acetylation of cyclo-oxygenase and back. Trends Pharmacol Sci 1989; 10: 453-8.
-
(1989)
Trends Pharmacol Sci
, vol.10
, pp. 453-458
-
-
Patrono, C.1
-
9
-
-
0028128106
-
-
Antiplatelet Trialists' Collaboration. Br Med J 1994; 308: 159-68.
-
(1994)
Br Med J
, vol.308
, pp. 159-168
-
-
-
10
-
-
0030911057
-
The International Stroke Trial: A randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke
-
International Stroke Trial Collaborative Group. The International Stroke Trial: a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. Lancet 1997; 349: 1569-81.
-
(1997)
Lancet
, vol.349
, pp. 1569-1581
-
-
-
11
-
-
0037138743
-
Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues
-
Thun MJ, Henley SJ, Patrono C. Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst 2002; 94: 252-266.
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 252-266
-
-
Thun, M.J.1
Henley, S.J.2
Patrono, C.3
-
13
-
-
0003111606
-
The history of anti-inflammatory drugs and their mechanism of action
-
Bazan N, Botting J and Vane JR, eds. Kluwer Academic Publishers, The Netherlands
-
Vane JR, Botting RM. The history of anti-inflammatory drugs and their mechanism of action. In Bazan N, Botting J and Vane JR, eds. New targets in inflammation: inhibitors of COX-2 or adhesion molecules. Kluwer Academic Publishers, The Netherlands, 1996, pp. 1-12.
-
(1996)
New Targets in Inflammation: Inhibitors of COX-2 or Adhesion Molecules
, pp. 1-12
-
-
Vane, J.R.1
Botting, R.M.2
-
14
-
-
0019195506
-
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
-
Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-6.
-
(1980)
Nature
, vol.288
, pp. 373-376
-
-
Furchgott, R.F.1
Zawadzki, J.V.2
-
15
-
-
0021287504
-
The role of endothelium in the responses of vascular smooth muscle to drugs
-
Furchgott RF. The role of endothelium in the responses of vascular smooth muscle to drugs. Ann Rev Pharmacol Toxicol 1984; 24: 175-97.
-
(1984)
Ann Rev Pharmacol Toxicol
, vol.24
, pp. 175-197
-
-
Furchgott, R.F.1
-
16
-
-
0000262966
-
Prostacyclin and endothelium-derived relaxing factor: Biological interactions and significance
-
Verstraete M, Vermylen J, Lijnen HR and Arnout J, eds. Leuven University Press
-
Moncada S, Palmer RMJ, Higgs EA. Prostacyclin and endothelium-derived relaxing factor: biological interactions and significance. In Verstraete M, Vermylen J, Lijnen HR and Arnout J, eds. Thrombosis and Haemostasis, Leuven University Press, 1987, pp. 597-618.
-
(1987)
Thrombosis and Haemostasis
, pp. 597-618
-
-
Moncada, S.1
Palmer, R.M.J.2
Higgs, E.A.3
-
17
-
-
0023198721
-
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
-
Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524-6.
-
(1987)
Nature
, vol.327
, pp. 524-526
-
-
Palmer, R.M.J.1
Ferrige, A.G.2
Moncada, S.3
-
18
-
-
0023912670
-
Vascular endothelial cells synthesize nitric oxide from L-arginine
-
Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 333: 664-6.
-
(1988)
Nature
, vol.333
, pp. 664-666
-
-
Palmer, R.M.J.1
Ashton, D.S.2
Moncada, S.3
-
20
-
-
0027752805
-
The L-arginine:nitric oxide pathway
-
Moncada S, Higgs EA. The L-arginine:nitric oxide pathway. N Engl J Med 1993; 329: 2002-12.
-
(1993)
N Engl J Med
, vol.329
, pp. 2002-2012
-
-
Moncada, S.1
Higgs, E.A.2
-
21
-
-
0026077959
-
Glutamate, nitric oxide and cell-cell signalling in the nervous system
-
Garthwaite J. Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci 1991; 14: 60-7.
-
(1991)
Trends Neurosci
, vol.14
, pp. 60-67
-
-
Garthwaite, J.1
-
22
-
-
0026531834
-
Biological roles of nitric oxide
-
Snyder SH, Bredt DS. Biological roles of nitric oxide. Sci Am 1992; 266: 68-71.
-
(1992)
Sci Am
, vol.266
, pp. 68-71
-
-
Snyder, S.H.1
Bredt, D.S.2
-
23
-
-
0025105828
-
The neurotransmitter of the non-adrenergic non-cholinergic inhibitory nerves to smooth muscle of the genital system
-
Moncada S and Higgs EA, eds. Elsevier Science Publishers B.V., Amsterdam
-
Gillespie JS, Liu X, Martin W. The neurotransmitter of the non-adrenergic non-cholinergic inhibitory nerves to smooth muscle of the genital system. In Moncada S and Higgs EA, eds. Nitric oxide from L-arginine: a bioregulatory system, Elsevier Science Publishers B.V., Amsterdam, 1990, pp. 147-64.
-
(1990)
Nitric Oxide from L-Arginine: A Bioregulatory System
, pp. 147-164
-
-
Gillespie, J.S.1
Liu, X.2
Martin, W.3
-
24
-
-
0026772074
-
Nitrergic transmission: Nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission
-
Rand MJ. Nitrergic transmission: nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission. Clin Exp Pharmacol Physiol 1992; 19: 147-69.
-
(1992)
Clin Exp Pharmacol Physiol
, vol.19
, pp. 147-169
-
-
Rand, M.J.1
-
25
-
-
0003014028
-
Nitric oxide and the regulation of cerebral arterial tone
-
Vincent S, ed. Academic Press Ltd., Orlando
-
Toda N. Nitric oxide and the regulation of cerebral arterial tone. In Vincent S, ed. Nitric oxide in the nervous system, Academic Press Ltd., Orlando, 1995, pp. 207-25.
-
(1995)
Nitric Oxide in the Nervous System
, pp. 207-225
-
-
Toda, N.1
-
26
-
-
0026034432
-
Role of nitric oxide synthesis in macrophage antimicrobial activity
-
Nathan CF, Hibbs JB Jr. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 1991; 3: 65-70.
-
(1991)
Curr Opin Immunol
, vol.3
, pp. 65-70
-
-
Nathan, C.F.1
Hibbs Jr., J.B.2
-
27
-
-
0027244724
-
Inflammation, immunoregulation and inducible nitric oxide synthase
-
Nussler AK, Billiar TR. Inflammation, immunoregulation and inducible nitric oxide synthase. J Leukoc Biol 1993; 54: 171-8.
-
(1993)
J Leukoc Biol
, vol.54
, pp. 171-178
-
-
Nussler, A.K.1
Billiar, T.R.2
-
28
-
-
0027549003
-
The role of endogenous nitric oxide in septic shock
-
Vallance P, Moncada S. The role of endogenous nitric oxide in septic shock. New Horizons 1993; 1: 77-86.
-
(1993)
New Horizons
, vol.1
, pp. 77-86
-
-
Vallance, P.1
Moncada, S.2
-
29
-
-
28044464985
-
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases
-
Cleeter MW, Cooper JM, Darley-Usmar VM, Moncada S, Schapira AH. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett 1994; 345: 50-4.
-
(1994)
FEBS Lett
, vol.345
, pp. 50-54
-
-
Cleeter, M.W.1
Cooper, J.M.2
Darley-Usmar, V.M.3
Moncada, S.4
Schapira, A.H.5
-
30
-
-
0028134892
-
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
-
Brown GC, Cooper C. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett, 1994; 356: 295-8.
-
(1994)
FEBS Lett
, vol.356
, pp. 295-298
-
-
Brown, G.C.1
Cooper, C.2
-
31
-
-
0027945838
-
NO potently and reversibly deenergizes mitochondria at low oxygen tension
-
Schweizer M, Richter C. NO potently and reversibly deenergizes mitochondria at low oxygen tension. Biochem Biophys Res Commun 1994; 204: 169-75.
-
(1994)
Biochem Biophys Res Commun
, vol.204
, pp. 169-175
-
-
Schweizer, M.1
Richter, C.2
-
32
-
-
0033573981
-
On the mechanism by which vascular endothelial cells regulate their oxygen consumption
-
Clementi E, Brown GC, Foxwell N, Moncada S. On the mechanism by which vascular endothelial cells regulate their oxygen consumption. Proc Natl Acad Sci USA, 1999; 96: 1559-62.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 1559-1562
-
-
Clementi, E.1
Brown, G.C.2
Foxwell, N.3
Moncada, S.4
-
33
-
-
0032560572
-
Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione
-
Clementi E, Brown GC, Feelisch M, Moncada S. Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci USA 1998; 13: 7631-6.
-
(1998)
Proc Natl Acad Sci USA
, vol.13
, pp. 7631-7636
-
-
Clementi, E.1
Brown, G.C.2
Feelisch, M.3
Moncada, S.4
-
34
-
-
2942713575
-
The effect of nitric oxide synthase activation triggered apoptosis in primary cortical neurons
-
Beltran B, Mathur A, Duchen MR, Erusalimksy JD, Moncada S. The effect of nitric oxide synthase activation triggered apoptosis in primary cortical neurons. J Neurochem 2001; 77: 676-90.
-
(2001)
J Neurochem
, vol.77
, pp. 676-690
-
-
Beltran, B.1
Mathur, A.2
Duchen, M.R.3
Erusalimksy, J.D.4
Moncada, S.5
-
35
-
-
0035909948
-
Different responses of astrocytes and neurons to nitric oxide: The role of glycolytically-generated ATP in astrocyte protection
-
Almeida A, Almeida J, Bolanos JP, Moncada S. Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically-generated ATP in astrocyte protection. Proc Natl Acad Sci USA, 2001; 98: 15294-9.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 15294-15299
-
-
Almeida, A.1
Almeida, J.2
Bolanos, J.P.3
Moncada, S.4
-
36
-
-
0037172971
-
Inhibition of mitochondrial respiration by endogenous nitric oxide: A critical step in Fas signalling
-
Beltrán B, Quintero M, Garcia-Zaragozá, O'Connor E, Esplugues JV, Moncada S. Inhibition of mitochondrial respiration by endogenous nitric oxide: a critical step in Fas signalling. Proc Natl Acad Sci USA 2002; 99: 8892-7.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8892-8897
-
-
Beltrán, B.1
Quintero, M.2
Garcia-Zaragozá3
O'Connor, E.4
Esplugues, J.V.5
Moncada, S.6
-
37
-
-
0028863627
-
Molecular mechanisms and therapeutic strategies related to nitric oxide
-
Moncada S, Higgs EA. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 1995; 9: 1319-30.
-
(1995)
FASEB J
, vol.9
, pp. 1319-1330
-
-
Moncada, S.1
Higgs, E.A.2
|