Capacity of ascorbyl palmitate to produce the ascorbyl radical in vitro: An electron spin resonance investigation

Physiological Research

Volumn 53, Issue 3, 2004, Pages 311-316

  Pokorski, M ^a   Gonet, B ^b  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^b POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

Ascorbate; Ascorbyl palmitate; Ascorbyl radical; Electron spin resonance spectroscopy; ESR signal

Indexed keywords

ASCORBIC ACID; ASCORBYL PALMITATE; SCAVENGER;

AMPLITUDE MODULATION; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTRON SPIN RESONANCE; EQUILIBRIUM CONSTANT; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIPID ANALYSIS; LIPID SOLUBILITY; LIPOPHILICITY; MALE; MEMBRANE CONDUCTANCE; MEMBRANE STRUCTURE; MOLECULAR BIOLOGY; PEPTIDE SYNTHESIS; PROCESS OPTIMIZATION; REACTION ANALYSIS; SIGNAL TRANSDUCTION;

ADULT; ASCORBIC ACID; BLOOD; BLOOD CHEMICAL ANALYSIS; DEHYDROASCORBIC ACID; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; MALE; MOLECULAR CONFORMATION;

EID: 2942718934     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. AUSTRIA R, SEMENZATO A, BETTERO A: Stability of vitamin C derivatives in solution and optical formulations. J Pharm Biomed Anal 15: 795-801, 1997.
2. BAADER WJ, HATZELMANN A, ULLRICH V: The suppression of granulocyte functions by lipophilic antioxidants. Biochem Pharmacol 37: 1089-1098, 1988.
3. BAARDSETH P: Effect of selected antioxidants on the stability of dehydrated mashed potatoes. Food Addit Contam 6: 201-207, 1999.
4. BHATTACHARYYA J, DATTA AG: Studies on the effects of lipopolysaccharide on lipid peroxidation of erythrocyte and its reversal by mannitol and glycerol. J Physiol Pharmacol 52: 145-152, 2001.
5. BUETTNER GR, JURKIEWlCZ BA: Ascorbate free radical as a marker of oxidative stress: an EPR study. Free Radic Biol Med 14: 49-55, 1993.
6. CIMBOLAITYTE JJ, NAKTINIS JJ, CERNIAUSKIENE LC, VANIN AF: On the nature of free radicals in dry animal tissues. Biofizika 27: 800-803, 1982.
7. EVANS RM, CURRIE L, CAMPBELL A: The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration. Br J Nutr 47: 473-482, 1982.
8. FLEMING JE, MIYASHITA K, QUAY SC, BENSCH KG: Bicycling ring formation is not necessary for the (auto)oxidation of ascorbic acid. Biochem Biophys Res Commun 115: 531-535, 1983.
9. GONET B: Free radical aspects of the ozone influence on blood. Physiol Chem Phys Med NMR 26: 273-286, 1994.
10. HEATH H: The distribution and possible functions of ascorbic acid in the eye. Exp Eye Res 1: 362-367, 1962.
11. JONKER D, LEE VS, HARGREAVES RJ, LAKE BG: Comparison of the effects of ascorbyl palmitate and L-ascorbic acid on paracetamol-induced hepatotoxicity in the mouse. Toxicology 2: 287-295, 1988.
12. KIM H, KIRSCHENBAUM LJ, ROSENTHAL I, RIESZ P: Photosensitized formation of ascorbate radicals by riboflavin: an ESR study. Photochem Photobiol 57: 777-784, 1993.
13. LEVINE M, CONRY-CANTILENA C, WANG Y, WELCH RW, WASHKO PW, DHARIWAL KR, PARK JB, LAZAREV A, GRAUMLICH JF, KING J, CANTILENA LR: Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 93: 3704-3709, 1996.
14. LIU Z-Q, MA L-P, LIU Z-L: Making vitamin C lipophilic enhances its protective effect against free radical induced peroxidation of low density lipoprotein. Chem Phys Lipids 95: 49-57, 1998.
15. MAY JM, QU Z-C, COBB CE: Accessibility and reactivity of ascorbate 6-palmitate bound to erythrocyte membranes. Free Radic Biol Med 4: 471-480, 1996.
16. MITRA A, RAVIKUMAR VC, BOURN WM, BOURCIER DR: Influence of ascorbic acid esters on acetaminophen-induced hepatotoxicity in mice. Toxicol Lett 44: 39-46, 1988.
17. MUELLER HW, TANNERT S: The significance of electron spin resonance of the ascorbic acid radical. Br J Cancer 53: 385-389, 1986.
18. OZTURK G, MULHOLLAND CW, HANNIGAN BM: Vitamin C decreases intracellular calcium level in human lymphoid cells. J Physiol Pharmacol 52: 285-292, 2001.
19. POKORSKI M, GONET B: Hypoxia depletes ascorbate in the cat carotid body. Respir Physiol 107: 213-218, 1997.
20. POKORSKI M, MARCZAK M, DYMECKA A, SUCHOCKI P: Ascorbyl palmitate as a carrier of ascorbate into neural tissues. J Biomed Sci 10: 193-198, 2003.
21. REBEC GC, PIERCE RC: A vitamin as neuromodulator: Ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission. Prog Neurobiol 43: 537-565, 1994.
22. REIBER H, MARTENS U, PRALL F, UHR M: Relevance of endogenous ascorbate and tocopherol for brain cell vitality indicated by photon emission. J Neurochem 62: 608-614, 1994.
23. ROSS D, MENDIRATTA S, QU Z, COBB CE, MAY JM: Ascorbate 6-palmitate protects human erythrocytes from oxidative damage. Free Radic Biol Med 26: 81-89, 1999.