Leflunomide attennuates hepatocyte injury by inhibiting Kupffer cells

World Journal of Gastroenterology

Volumn 10, Issue 11, 2004, Pages 1608-1611

  Yao, Hong Wei ^a   Li, Jun ^b   Chen, Ji Qiang ^a   Xu, Shu Yun ^b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; CYTOKINE; DEXAMETHASONE; DRUG METABOLITE; INTERLEUKIN 1; LEFLUNOMIDE; LIPOPOLYSACCHARIDE; MESSENGER RNA; PRONASE; TERIFLUNOMIDE; TUMOR NECROSIS FACTOR ALPHA; ANILINE DERIVATIVE; HYDROXYBUTYRIC ACID; IMMUNOSUPPRESSIVE AGENT; ISOXAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL CONTACT; CELL CULTURE; CELL DAMAGE; CELL ISOLATION; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DRUG MECHANISM; ENZYMATIC DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSCRIPTION; HEPATITIS; IMMUNE RESPONSE; KUPFFER CELL; LIVER CELL; LIVER INJURY; MALE; MONOCULTURE; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; SUPERNATANT; TIME; ANIMAL; CELL COMMUNICATION; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANILINE COMPOUNDS; ANIMALS; CELL COMMUNICATION; CELLS, CULTURED; HEPATITIS; HEPATOCYTES; HYDROXYBUTYRATES; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1; ISOXAZOLES; KUPFFER CELLS; LIPOPOLYSACCHARIDES; MALE; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 2942708096     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v10.i11.1608     Document Type: Article

References (26)

1. Shito M, Balis UJ, Tompkins RG, Yarmush ML, Toner M. A fulminant hepatic failure model in the rat: involvement of interleukin-1beta and tumor necrosis factor-alpha. Dig Dis Sci 2001; 46: 1700-1708
2. Bradham CA, Plumpe J, Manns MP, Brenner DA, Trautwein C. Mechanisms of hepatic toxicity. I. TNF-induced liver injury. Am J Physiol 1998; 275: G387-392
3. Nishioji K, Okanoue T, Mori T, Sakamoto S, Itoh Y. Experimental liver injury induced by Propionibacterium acnes and lipopolysaccharide in macrophage colony stimulating factor-deficient osteopetrotic (op/op) mice. Dig Dis Sci 1999; 44: 1975-1984
4. Sermon F, Le Moine O, Gustot T, Quertinmont E, Louis H, Nagy N, Degraef C, Deviere J. Chronic alcohol exposure sensitizes mice to galactosamine-induced liver injury through enhanced keratinocyte chemoattractant and defective IL-10 production. J Hepatol 2003; 39: 68-76
5. Louis H, Le Moine O, Goldman M, Deviere J. Modulation of liver injury by interleukin-10. Acta Gastroenterol Belg 2003; 66: 7-14
6. Enomoto N, Ikejima K, Yamashina S, Hirose M, Shimizu H, Kitamura T, Takei Y, Sato And N, Thurman RG. Kupffer cell sensitization by alcohol involves increased permeability to gut-derived endotoxin. Alcohol Clin Exp Res 2001; 25(6 Suppl): 51S-54S
7. Lukkari TA, Jarvelainen HA, Oinonen T, Kettunen E, Lindros KO. Short-term ethanol exposure increases the expression of Kupffer cell CD14 receptor and lipopolysaccharide binding protein in rat liver. Alcohol Alcohol 1999; 34: 311-319
8. Wang JH, Redmond HP, Wu QD, Bouchier-Hayes D. Nitric oxide mediates hepatocyte injury. Am J Physiol 1998; 275: G1117-1126
9. Kmiec Z. Cooperation of liver cells in health and disease. Adv Anat Embryol Cell Biol 2001; 161: 1-151
10. Hoek JB, Pastorino JG. Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol 2002; 27: 63-68
11. Sanders S, Harisdangkul V. Leflunomide for the treatment of rheumatoid arthritis and autoimmunity. Am J Med Sci 2002; 323: 190-193
12. Osiri M, Shea B, Robinson V, Suarez-Almazor M, Strand V, Tugwell P, Wells G. Leflunomide for the treatment of rheumatoid arthritis: a systematic review and metaanalysis. J Rheumatol 2003; 30: 1182-1190
13. Williams JW, Mital D, Chong A, Kottayil A, Millis M, Longstreth J, Huang W, Brady L, Jensik S. Experiences with leflunomide in solid organ transplantation. Transplantation 2002; 73: 358-366
14. Kessel A, Toubi E. Leflunomide in systemic lupus erythematosus. Harefuah 2002; 141: 355-357
15. Prajapati DN, Knox JF, Emmons J, Saeian K, Csuka ME, Binion DG. Leflunomide treatment of Crohn's disease patients intolerant to standard immunomodulator therapy. J Clin Gastroenterol 2003; 37: 125-128
16. Ko YJ, Small EJ, Kabbinavar F, Chachoua A, Taneja S, Reese D, DePaoli A, Hannah A, Balk SP, Bubley GJ. A multi-institutional phase ii study of SU101, a platelet-derived growth factor receptor inhibitor, for patients with hormone-refractory prostate cancer. Clin Cancer Res 2001; 7: 800-805
17. Lucient J, Dias VC, LeGatt DF, Yatscoff RW. Blood distribution and single-dose pharmacokinetics of leflunomide. Ther Drug Monit 1995; 17: 454-459
18. Li J, Yao HW, Jin Y, Zhang YF, Li CY, Xu SY. Pharmacokinetics of leflunomide in Chinese healthy volunteers. Acta Pharmacol Sin 2002; 23: 551-555
19. Rozman B. Clinical pharmacokinetics of leflunomide. Clin Pharmacokinet 2002; 41: 421-430
20. Yao HW, Li J, Jin Y, Zhang YF, Li CY, Xu SY. Effect of leflunomide on immunological injury in mice. World J Gastroenterol 2003; 9: 320-323
21. Yao HW, Jin Y, Li J, Zhang YF, Li CY, Xu SY. Effect of leflunomide on immunological injury. Yaoxue Xuebao 2001; 36: 727-730
22. Yao HW, Jin Y, Li J, Zhang YF, Li CY, Xu SY. Effect of leflunomide on the acute chemical injury. Anhui Yiyao 2001; 5: 7-9
23. Zhang GL, Lin ZB, Zhang B. Effects of selective induceble nitric oxide synthase inhibitor on immunological hepatic injury in rat. Zhonghua Yixue Zazhi 1998; 78: 540-543
24. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 1976; 13: 29-83
25. Smedsrod B, Pertoft H, Eggertsen G, Sundstrom C. Functional and morphological characterization of cultures of Kupffer cells and liver endothelial cells prepared by means of density separation in Percoll, and selective substrate adherence. Cell Tissue Res 1985; 241: 639-649
26. Yin F, Yang YJ, Yu PL, Mao DA, Tao YG. Tumor necrosis factor-α in brain tissues of rats with pertussis bacilli induced brain edema. Chin J Contemp Pediatr 2000; 2: 82-85