Insertion/deletion polymorphism of the angiotensin converting enzyme gene influences carbohydrate metabolism, oxidative stress and target organ damage in type 2 diabetes mellitus;Az ACE gén polimorfizmusának befolyása a szénhidrát-anyagcserére, az oxidatív stresszre és a célszervkárosodásra 2-es típusú diabetesben

Orvosi Hetilap

Volumn 145, Issue 16, 2004, Pages 855-859

  Molnár, Gergo Attila ^a,e   Wagner, Zoltán ^a   Wagner, László ^a   Melegh, Béla ^b   Koszegi, Tamás ^c   Degrell, Péter ^a   Bene, Judit ^d   Tamaskó, Mónika ^a   Laczy, Boglárka ^a   Nagy, Judit ^a   Wittmann, István ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b Orvosi Genetikai es Gyermekfejlodéstani Intézet   (Hungary)

^c Klinikai Kémiai Intézet   (Hungary)

^d UNIVERSITY OF PÉCS   (Hungary)

^e NONE   (Hungary)

Author keywords

ACE gene polymorphism; Albuminuria; Fructosamine; Hypertension; Oxidative stress; Type 2 diabetes

Indexed keywords

CARBOHYDRATE; DIPEPTIDYL CARBOXYPEPTIDASE; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; FRUCTOSAMINE; INSULIN;

ARTICLE; CARBOHYDRATE METABOLISM; GENE DELETION; GENE INSERTION; GENETIC POLYMORPHISM; MULTIPLE ORGAN FAILURE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; TARGET ORGAN; ADULT; AGED; BLOOD; BLOOD PRESSURE; CROSS-SECTIONAL STUDY; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; KIDNEY FUNCTION TEST; MALE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; RENOVASCULAR HYPERTENSION;

ADULT; AGED; AGED, 80 AND OVER; ANTIHYPERTENSIVE AGENTS; BLOOD GLUCOSE; BLOOD PRESSURE; CARBOHYDRATE METABOLISM; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; FRUCTOSAMINE; GENE DELETION; HUMANS; HYPERTENSION; HYPERTENSION, RENOVASCULAR; HYPOGLYCEMIC AGENTS; INSULIN; KIDNEY FUNCTION TESTS; MALE; MIDDLE AGED; MUTAGENESIS, INSERTIONAL; OXIDATIVE STRESS; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC;

EID: 2942707725     PISSN: 00306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Chiang, F. T., Hsu, K. L., Chen, W. M. és mtsai: Determination of angiotensin I-converting enzyme gene polymorphisms: stepdown PCR increases detection of heterozygotes. Clin. Chem., 1998, 44, 1353-1356.
2. Fava, S., Azzopardi, J., Ellard, S. és mtsa: ACE gene polymorphism as a prognostic indicator in patients with type 2 diabetes and established renal disease. Diabetes Care, 2001, 24, 2115-2120.
3. Higashi, Y., Sasaki, S., Nakagawa, K. és mtsai: Endothelial function and oxidative stress in renovascular hypertension. N. Engl. J. Med., 2002, 346, 1954-1962.
4. Keavney, B. D., Dudley, C. R., Stratton, I. M. és mtsai: UK Prospective Diabetes Study (UKPDS) 14: association of angiotensin-converting enzyme insertion/deletion polymorphism with myocardial infarction in NIDDM. Diabetologia, 1995, 38, 948-952.
5. Kennon, B., Petrie, J. R., Small, M. és mtsai: Angiotensin-converting enzyme gene and diabetes mellitus. Diab. Med., 1999, 16, 448-58.
6. Kugelman, A., Choy, H. A., Liu, R. és mtsai: γ-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells. Am. J. Respir. Cell. Mol. Biol., 1994, 11, 586-592.
7. Lee, Y-J., Tsai, J. C. R.: ACE gene insertion/deletion polymorphism associated with 1998 World Health Organization definition of metabolic syndrome in Chinese type 2 diabetic patients. Diabetes Care, 2002, 25, 1002-1008.
8. Nakai, K., Itoh, C., Miura, Y. és mtsai: Deletion polymorphism of the angiotensin I-convening enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese. Circulation, 1994, 90, 2199-2202.
9. Niwa, T., Tsukushi, S.: 3-deoxyglucosone and AGEs in uremic complications: inactivation of glutathione peroxidase by 3-deoxyglucosone. Kidney Intr. Suppl., 2001, 78, S37-41.
10. Parving, H-H.: Diabetic nephropathy: Prevention and treatment. Kidney Int., 2001, 60, 2040-2055.
11. Price, D. A., Lansang, M. C., Osei, S. Y. és mtsai: Type 2 diabetes, obesity, and the renal response to blocking the renin system with irbesartan. Diabet. Med., 2002, 19, 858-861.
12. Solini, A., Vestra, M. D., Saller, A. és mtsai: The angiotensin-converting enzyme DD genotype is associated with glomerulopathy lesions in type 2 diabetes. Diabetes, 2002, 51, 251-255.
13. UK Prospective Diabetes Study Group: Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ, 1998, 317, 703-713.
14. Vlassara, H., Palace, M. R.: Diabetes and advanced glycation endproducts. J. Intern. Med., 2002, 251, 87-101.
15. Wahid, S. T., Sultan, J., Handley, G. és mtsai: Serum fructosamine as a marker of 5-year risk of developing diabetes mellitus in patients exhibiting stress hyperglycaemia. Diabet. Med., 2002, 19, 543-548.
16. Zee, R. Y., Lou, Y., Griffiths, L. R. és mtsa: Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension. Biochem. Biophys. Res. Commun., 1992, 184, 9-15.