Gene-directed enzyme prodrug therapy for osteosarcoma: Sensitization to CPT-11 in vitro and in vivo by adenoviral delivery of a gene encoding secreted carboxylesterase-2

Molecular Cancer Therapeutics

Volumn 2, Issue 8, 2003, Pages 765-771

  Oosterhoff, Dinja ^a   Witlox, M Adhiambo ^a   Van Beusechem, Victor W ^a   Haisma, Hidde J ^b   Schaap, Gerard R ^c   Bras, Johannes ^c   Kruyt, Frank A ^a   Molenaar, Bonnie ^a   Boven, Epie ^a   Wuisman, Paul I J M ^a   Pinedo, Herbert M ^a   Gerritsen, Winald R ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7-ETHYL-10-HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CARBOXYLESTERASE; DRUG DERIVATIVE; IRINOTECAN; PRODRUG;

ADENOVIRUS; ANIMAL; ARTICLE; CELL CULTURE; GENE THERAPY; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HUMAN; METHODOLOGY; MOUSE; NUDE MOUSE; OSTEOSARCOMA; SECRETION; XENOGRAFT;

ADENOVIRIDAE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CARBOXYLESTERASE; GENE THERAPY; GENETIC VECTORS; HUMANS; MICE; MICE, NUDE; OSTEOSARCOMA; PRODRUGS; TRANSDUCTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 2942679889     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Renard, A. J., Veth, R. P., Schreuder, H. W., Pruszczynski, M., Bokkerink, J. P., van Hoesel, Q. G., and van Der Staak, F. J. Osteosarcoma: oncologic and functional results. A single institutional report covering 22 years. J. Surg. Oncol., 72: 124-129, 1999.
2. Lindner, N. J., Ramm, O., Hillmann, A., Roedl, R., Gosheger, G., Brinkschmidt, C., Juergens, H., and Winkelmann, W. Limb salvage and outcome of osteosarcoma. The University of Muenster experience. Clin. Orthop., 358: 83-89, 1999. (Pubitemid 29066077)
3. Bacci, G., Ferrari, S., Longhi, A., Forni, C., Bertoni, F., Fabbri, N., Zavatta, M., and Versari, M. Neoadjuvant chemotherapy for high grade osteosarcoma of the extremities: long-term results for patients treated according to the Rizzoli IOR/OS-3b protocol. J. Chemother., 13: 93-99, 2001. (Pubitemid 32174727)
4. Bacci, G., Ferrari, S., Longhi, A., Perin, S., Forni, C., Fabbri, N., Salduca, N., Versari, M., and Smith, K. V. Pattern of relapse in patients with osteosarcoma of the extremities treated with neoadjuvant chemotherapy. Eur. J. Cancer, 37: 32-38, 2001. (Pubitemid 32119357)
5. Longhi, A., Fabbri, N., Donati, D., Capanna, R., Briccoli, A., Biagini, R., Bernini, G., Ferrari, S., Versari, M., and Bacci, G. Neoadjuvant chemotherapy for patients with synchronous multifocal osteosarcoma: results in eleven cases. J. Chemother., 13: 324-330, 2001. (Pubitemid 32575144)
6. Kushner, B. H., Kramer, K., Meyers, P. A., Wollner, N., and Cheung, N. K. Pilot study of topotecan and high-dose cyclophosphamide for resistant pediatric solid tumors. Med. Pediatr. Oncol., 35: 468-474, 2000.
7. Saylors, R. L., III, Stine, K. C., Sullivan, J., Kepner, J. L., Wall, D. A., Bernstein, M. L., Harris, M. B., Hayashi, R., and Vietti, T. J. Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: a Pediatric Oncology Group Phase II study. J. Clin. Oncol., 19: 3463-3469, 2001. (Pubitemid 32730082)
8. Pratesi, G., De Cesare, M., Carenini, N., Perego, P., Righetti, S. C., Cucco, C., Merlini, L., Pisano, C., Penco, S., Carminati, P., Vesci, L., and Zunino, F. Pattern of antitumor activity of a novel camptothecin, ST1481, in a large panel of human tumor xenografts. Clin. Cancer Res., 8: 3904-3909, 2002. (Pubitemid 35424785)
9. Satoh, T., Hosokawa, M., Atsumi, R., Suzuki, W., Hakusui, H., and Nagai, E. Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase. Biol. Pharm. Bull., 17: 662-664, 1994. (Pubitemid 24186112)
10. Satoh, T., and Hosokawa, M. The mammalian carboxylesterases: from molecules to functions. Annu. Rev. Pharmacol. Toxicol., 38: 257-288, 1998. (Pubitemid 28231496)
11. Gupta, E., Mick, R., Ramirez, J., Wang, X., Lestingi, T. M., Vokes, E. E., and Ratain, M. J. Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients. J. Clin. Oncol., 15: 1502-1510, 1997. (Pubitemid 27167386)
12. Ko, S. C., Cheon, J., Kao, C., Gotoh, A., Shirakawa, T., Sikes, R. A., Karsenty, G., and Chung, L. W. Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models. Cancer Res., 56: 4614-4619, 1996. (Pubitemid 26338059)
13. Cheon, J., Ko, S. C., Gardner, T. A., Shirakawa, T., Gotoh, A., Kao, C., and Chung, L. W. Chemogene therapy: osteocalcin promoter-based suicide gene therapy in combination with methotrexate in a murine osteosarcoma model. Cancer Gene Ther., 4: 359-365, 1997. (Pubitemid 127667128)
14. Shirakawa, T., Ko, S. C., Gardner, T. A., Cheon, J., Miyamoto, T., Gotoh, A., Chung, L. W., and Kao, C. In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy. Cancer Gene Ther., 5: 274-280, 1998. (Pubitemid 128640013)
15. Billiau, A., Edy, V. G., Heremans, H., Van Damme, J., Desmyter, J., Georgiades, J. A., and De Somer, P. Human interferon: mass production in a newly established cell line. MG- 63, Antimicrob. Agents Chemother., 12: 11-15, 1977. (Pubitemid 8143077)
16. Rhim, J. S., Putman, D. L., Arnstein, P., Huebner, R. J., and McAllister, R. M. Characterization of human cells transformed in vitro by N-methyl-N′-nitro-N-nitrosoguanidine. Int. J. Cancer, 19: 505-510, 1977. (Pubitemid 8073402)
17. Fogh, J., Fogh, J. M., and Orfeo, T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice, J. Natl. Cancer Inst. (Bethesda), 59: 221-226, 1977. (Pubitemid 8144854)
18. Rochet, N., Dubousset, J., Mazeau, C., Zanghellini, E., Farges, M. F., de Novion, H. S., Chompret, A., Delpech, B., Cattan, N., Frenay, M., and Gioanni, J. Establishment, characterisation and partial cytokine expression profile of a new human osteosarcoma cell line (CAL 72). Int. J. Cancer, 82: 282-285, 1999. (Pubitemid 29293789)
19. Witlox, M. A., Van Beusechem, V. W., Grill, J., Haisma, H. J., Schaap, G., Bras, J., Van Diest, P., De Gast, A., Curiel, D. T., Pinedo, H. M., Gerritsen, W. R., and Wuisman, P. I. Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma. J. Gene Med., 4: 510-516, 2002. (Pubitemid 40268377)
20. He, T. C., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., and Vogelstein, B. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA, 95: 2509-2514, 1998. (Pubitemid 28145972)
21. Oosterhoff, D., Pinedo, H. M., van der Meulen, I. H., de Graaf, M., Sone, T., Kruyt, F. A., van Beusechem, V. W., Haisma, H. J., and Gerritsen, W. R. Secreted and tumour targeted human carboxylesterase for activation of irinotecan. Br. J. Cancer, 87: 659-664, 2002.
22. van Beusechem, V. W., van Rijswijk, A. L., van Es, H. H., Haisma, H. J., Pinedo, H. M., and Gerritsen, W. R. Recombinant adenovirus vectors with knobless fibers for targeted gene transfer. Gene Ther., 7: 1940-1946, 2000.
23. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
24. Chan, S., Gabra, H., Hill, F., Evan, G., and Sikora, K. A novel tumour marker related to the c-myc oncogene product. Mol. Cell Probes, 1: 73-82, 1987.
25. Jansen, W. J., Zwart, B., Hulscher, S. T., Giaccone, G., Pinedo, H. M., and Boven, E. CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants. Int. J. Cancer, 70: 335-340, 1997. (Pubitemid 27099604)
26. Kojima, A., Hackett, N. R., Ohwada, A., and Crystal, R. G. In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors. J. Clin. Investig., 101: 1789-1796, 1998. (Pubitemid 28198510)
27. Humerickhouse, R., Lohrbach, K., Li, L., Bosron, W. F., and Dolan, M. E. Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2. Cancer Res., 60: 1189-1192, 2000. (Pubitemid 30151980)
28. Wierdl, M., Morton, C. L., Weeks, J. K., Danks, M. K., Harris, L. C., and Potter, P. M. Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase. Cancer Res., 61: 5078-5082, 2001. (Pubitemid 32681538)
29. Khanna, R., Morton, C. L., Danks, M. K., and Potter, P. M. Proficient metabolism of irinotecan by a human intestinal carboxylesterase. Cancer Res., 60: 4725-4728, 2000.
30. Morton, C. L., Wierdl, M., Oliver, L., Ma, M. K., Danks, M. K., Stewart, C. F., Eiseman, J. L., and Potter, P. M. Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase. Cancer Res., 60: 4206-4210, 2000. (Pubitemid 30636606)