Telomere erosion: A new link between HLA DR4 and rheumatoid arthritis?

Trends in Immunology

Volumn 25, Issue 7, 2004, Pages 339-341

  Salmon, Mike ^a   Akbar, Arne N ^b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GLYCOPROTEIN; HEAT SHOCK PROTEIN; HLA DR1 ANTIGEN; HLA DR4 ANTIGEN; HLA DR6 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ALPHA HELIX; AMINO ACID SEQUENCE; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; BLOOD CELL; CELL DIVISION; CHROMOSOME TRANSLOCATION; GENE LINKAGE DISEQUILIBRIUM; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GRANULOCYTE; HOMEOSTASIS; HUMAN; NONHUMAN; PROTEIN FAMILY; PROTEIN MOTIF; RHEUMATOID ARTHRITIS; SENESCENCE; SEQUENCE HOMOLOGY; SHORT SURVEY; T LYMPHOCYTE; TELOMERE; THYMUS;

EID: 2942652784     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2004.05.002     Document Type: Short Survey

References (27)

1. Stastny P. Association of the B cell alloantigen DRw4 with rheumatoid arthritis. N. Engl. J. Med. 298:1978;869-871
2. + rheumatoid arthritis. Lancet. 2:1987;1002-1004
3. Wordsworth B.P., et al. HLA-DR4 subtype frequency in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the human leucocyte antigen class II region. Proc. Natl. Acad. Sci. U. S. A. 86:1989;10049-10053
4. Gregersen P.K., et al. Molecular diversity of HLA-DR4 haplotypes. Proc. Natl. Acad. Sci. U. S. A. 83:1986;2642-2646
5. Willkens R.F., et al. Association of HLA-DW16 with rheumatoid-arthritis in Yakima indians - further evidence for the shared epitope hypothesis. Arthritis Rheum. 34:1991;43-47
6. Salmon M. The immunogenetic componant of susceptibility to rheumatoid arthritis. Curr. Opin. Rheumatol. 4:1992;342-347
7. Winchester R.J., Gregersen P.K. The molecular basis of susceptibility to rheumatoid arthritis: the conformational equivalence hypothesis. Springer Semin. Immunopathol. 10:1988;119-139
8. Albani S., et al. The susceptibility sequence to rheumatoid arthritis is a cross reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule. J. Clin. Invest. 89:1992;327-331
9. Roudier J., et al. Susceptibility to rheumatoid arthritis maps to a T cell epitope shared by the HLA DW4 DR β1 chain and the Epstein-Barr virus glycoprotein gp110. Proc. Natl. Acad. Sci. U. S. A. 86:1989;5104-5108
10. Salmon M., Gaston J.S.H. The role of T lymphocytes in rheumatoid arthritis. Br. Med. Bull. 51:1995;332-345
11. Gough A., et al. Genetic typing of patients with inflammatory arthritis at presentation is predictive of outcome. Arthritis Rheum. 37:1994;1166-1170
12. van Zeben D., et al. Association of HLA-DR4 with a more progressive disease course in patients with rheumatoid arthritis. Arthritis Rheum. 34:1991;822-830
13. Patil N.S., et al. Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles. J. Immunol. 167:2001;7157-7168
14. Hill J.A., et al. The conversion of arginine to citrulline allows for a high affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J. Immunol. 171:2003;538-541
15. Goldbach-Mansky R., et al. Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res. 2:2000;236-243
16. Schönland S.O., et al. Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages. Proc. Natl. Acad. Sci. U. S. A. 100:2003;13471-13476
17. Koetz K., et al. T cell homeostasis in patients with rheumatoid arthritis. Proc. Natl. Acad. Sci. U. S. A. 97:2000;9203-9208
18. Allsopp R.C., et al. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 89:1992;10114-10118
19. Olovnikov A.M. A theory of marginotomy: the incomplete copying of template margin in enzymatic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol. 41:1973;181-190
20. + T cells during acute Epstein-Barr virus infection. Blood. 97:2001;700-707
21. + T cell senescence in mice and men. Mech. Ageing Dev. 121:2000;69-76
22. Matthews N., et al. CD45RB exon expression by T lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum. 36:1993;603-607
23. Wu K., et al. Telomerase activity is increased and telomere length shortened in T cells from blood of patients with atopic dermatitis and psoriasis. J. Immunol. 165:2000;4742-4747
24. + regulatory T cells. Immunology. 109:2003;319-325
25. + regulatory T cells. Eur. J. Immunol. 32:2002;1621-1630
26. + regulatory T cells in rheumatoid arthritis: an activated, highly suppressive population in the synovial fluid. Arthritis Rheum. (in press).
27. Sakaguchi N., et al. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature. 426:2003;454-460