TT virus-derived apoptosis-inducing protein induces apoptosis preferentially in hepatocellular carcinoma-derived cells

Journal of General Virology

Volumn 85, Issue 6, 2004, Pages 1445-1450

  Kooistra, Klaas ^a   Zhang, Ying Hui ^a,b   Henriquez, Niek V ^a   Weiss, Bertram ^c   Mumberg, Dominik ^c   Noteborn, Mathieu H M ^a,b  

^a Leadd BV   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTIN; VIRUS PROTEIN; CAPSID PROTEIN; VP3 PROTEIN, CHICKEN ANEMIA VIRUS;

APOPTOSIS; ARTICLE; CIRCOVIRIDAE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; TORQUE TENO VIRUS; TUMOR CELL LINE; VIRUS VIRULENCE; AMINO ACID SEQUENCE; ANIMAL; CELL STRAIN COS1; LIVER TUMOR; MOLECULAR GENETICS; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY;

CHICKEN ANEMIA VIRUS; GALLUS GALLUS; TT VIRUS;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CAPSID PROTEINS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; COS CELLS; HUMANS; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; TORQUE TENO VIRUS; VIRAL PROTEINS;

EID: 2942631186     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.79790-0     Document Type: Article

References (38)

1. Asabe, S., Nishizawa, T., Iwanari, H. & Okamoto, H. (2001). Phosphorylation of serine-rich protein encoded by open reading frame 3 of the TT virus genome. Biochem Biophys Res Comm 286, 298-304.
2. Bando, M., Ohno, S., Oshikawa, K., Takahashi, M., Okamoto, H. & Sugiyama, Y. (2001). Infection of TT virus in patients with idiopathic pulmonary fibrosis. Respir Med 95, 935-942.
3. Bendinelli, M., Pistello, M., Maggi, F., Fornai, C., Freer, G. & Vatteroni, M. L. (2002). Molecular properties, biology, and clinical implications of TT virus, a recently identified widespread infectious agent of humans. Clin Microbiol Rev 14, 98-113.
4. Camci, C., Guney, C., Balkan, A., Buyukberber, N., Buyukberber, S., Kadayifci, A. & Kubar, A. (2002). The prevalence of TT virus in cancer patients. New Microbiol 25, 463-468.
5. Danen-Van Oorschot, A. A. A. M., Fischer, D. F., Grimbergen, J. M. & 7 other authors (1997). Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. Proc Natl Acad Sci U S A 94, 5843-5847.
6. Danen-Van Oorschot, A. A. A. M., Van der Eb, A. J. & Noteborn, M. H. M. (2000). The chicken anemia virus-derived protein Apoptin requires activation of caspases for induction of apoptosis in human tumor cells. J Virol 74, 7072-7078.
7. Diller, L., Kassel, J., Nelson, C. & 7 other authors (1990). P53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol 10, 5772-5781.
8. Erker, J. C., Leary, T. P., Desai, S. M., Chalmers, M. L. & Mushahwar, I. K. (1999). Analysis of TT virus full-length genomic sequences. J Gen Virol 80, 1743-1750.
9. Gebbink, M. F., Kranenburg, O., Poland, M., Van Horck, F. P., Houssa, B. & Moolenaar, W. H. (1997). Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. J Cell Biol 137, 1603-1613.
10. Hino, S. (2002). TTV, a new human virus with single stranded circular DNA genome. Rev Med Virol 12, 151-158.
11. Hu, Z.-J., Lang, Z.-W., Zhou, Y.-S., Yan, H.-P., Huang, D.-Z., Chen, W. R. & Luo, Z.-X. (2002). Clinicopathological study on TTV infection in hepatitis of unknown etiology. World J Gastroenterol 8, 288-293.
12. Kamahora, T., Hino, S. & Miyata, H. (2000). Three spliced mRNAs of TT virus transcribed from a plasmid containing the entire genome in COS1 cells. J Virol 74, 9980-9986.
13. Leary, T. P., Erker, J. C., Chalmers, M. L., Desai, S. M. & Mushahwar, I. K. (1999). Improved detection systems for TT virus reveal high prevalence in humans, non-human primates and farm animals. J Gen Virol 80, 2115-2120.
14. Miyata, H., Tsunoda, H., Kazi, A., Yamada, A., Khan, M. A., Murakami, J., Kamahora, T., Shiraki, K. & Hino, S. (1999). Identification of a novel GC-rich 113-nucleotide region to complete the circular, single-stranded DNA genome of TT virus, the first human circovirus. J Virol 73, 3582-3586.
15. Moriyama, M., Matsumura, H., Shimizu, T. & 7 other authors (2001). Histopathologic impact of TT virus infection on the liver of type C chronic hepatitis and liver cirrhosis in Japan. J Med Virol 64, 74-81.
16. Mushahwar, I. K., Erker, J. C., Muerhoff, A. S., Leary, T. P., Simons, J. N., Birkenmeyer, L. G., Chalmers, M. L., Pilot-Matias, T. J. & Dexai, S. M. (1999). Molecular and biophysical characterization of TT virus: evidence for a new virus family infecting humans. Proc Natl Acad Sci U S A 96, 3177-3182.
17. Nishizawa, T., Okamoto, H., Konishi, K., Yoshizawa, H., Miyakawa, Y. & Mayumi, M. (1997). A novel DNA virus (TTV) associated with elevated transaminase levels in post transfusion hepatitis of unknown etiology. Biochem Biophys Res Comm 241, 92-97.
18. Noteborn, M. H. M. (2002). Apoptin as an anticancer therapy. In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins. Cancer Drug Discovery and Development, pp 275-287. Edited by N. La Thangue & L. Bandara. Totowa, NJ: Humana Press.
19. Noteborn, M. H. M., De Boer, G. F., Kant, A., Koch, G., Bos, J. L., Zantema, A. & Van der Eb, A. J. (1990). Expression of avian leukemia virus env-gp85 in Spodoptera frugiperda cells by use of a baculovirus expression vector. J Gen Virol 71, 2641-2648.
20. Noteborn, M. H. M., De Boer, G. F., Roozelaar, D. J. & 7 other authors (1991). Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle. J Virol 65, 3131-3139.
21. Noteborn, M. H. M., Danen-van Oorschot, A. A. A. M. & Van der Eb, A. J. (1998). Chicken anemia virus: induction of apoptosis by a single protein of a single-stranded DNA virus. Semin Virol 8, 497-504.
22. Okamoto, H., Nishizawa, T., Kato, N., Ukita, M., Ikeda, H., Iizuka, H., Miyakawa, Y. & Mayumi, M. (1998). Molecular cloning and characterization of a novel DNA virus (TTV) associated with post transfusion hepatitis of unknown etiology. Hepatol Res 10, 1-16.
23. Okamoto, H., Takahashi, M., Nishizawa, T., Tawara, A., Fukai, K., Muramatsu, U., Naito, Y. & Yoshikawa, A. (2002). Genomic characterization of TT viruses (TTVs) in pigs, cats and dogs and their relatedness with species-specific TTVs in primates and tupaias. J Gen Virol 83, 1291-1297.
24. Peng, Y. H., Nishizawa, T., Takahashi, M., Ishikawa, T., Yoshikawa, A. & Okamoto, H. (2002). Analysis of entire genomes of thirteen TT virus variants classifiable into the fourth and fifth genetic groups, isolated from viremic infants. Arch Virol 147, 21-41.
25. Pietersen, A. M., Van der Eb, M. M., Rademaker, H. J. & 10 other authors (1999). Specific tumor-cell killing with adenovirus vectors containing the Apoptin gene. Gene Ther 6, 882-892.
26. Pineau, P., Meddeb, M., Raselli, R., Qin, L. X., Terris, B., Tang, Z. Y., Tiollais, P., Mazzaferro, V. & Dejean, A. (2000). Effect of TT virus infection on hepatocellular carcinoma development: results of a Euro-Asian survey. J Infect Dis 181, 1138-1142.
27. Puisieux, A., Galvin, K., Troalen, F. & 7 other authors (1993). Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines. FASEB J 7, 1407-1413.
28. Rohn, J. L., Zhang, Y.-H., Aalbers, R. I. J. M. & 8 other authors (2002). A tumor-specific kinase activity regulates the viral death protein Apoptin. J Biol Chem 227, 50820-50827.
29. Suzuki, F., Chayama, K., Tsubota, A. & 7 other authors (2001). Pathogenic significance and organic virus levels in patients infected with TT virus. Intervirology 44, 291-297.
30. Tagger, A., Donato, F., Ribero, M. L. & 7 other authors (1999). A case-control study on a novel DNA virus (TT-virus) infection and hepatocellular carcinoma. The Brescia HCC study. Hepatology 30, 294-299.
31. Takahashi, K., Iwasa, Y., Hijakata, M. & Mishiro, S. (2000). Identification of a new human DNA virus (TTV-like mini virus, TLMV) intermediately related to TT virus and chicken anemia virus. Arch Virol 145, 979-993.
32. Telford, W. G., King, L. E. & Fraker, P. J. (1992). Comparative evaluation of several DNA binding dyes in the detection of apoptosis-associated chromatin degradation by flow cytometry. Cytometry 13, 137-143.
33. Van der Eb, M. M., Pietersen, A. M., Speetjens, F. M., Kuppen, P. J. K., Van Velde, C. J. H., Noteborn, M. H. M. & Hoeben, R. C. (2002). Gene therapy with Apoptin induces regression of xenografted human hepatomas. Cancer Gene Ther 9, 53-61.
34. Van der Vorm, E. R., Kuipers, A., Kielkopf-Renner, S., Krans, H. M., Moeller, W. & Maassen, J. A. (1994). A mutation in the insulin receptor that impairs proreceptor processing but not insulin binding. J Biol Chem 269, 14297-14302.
35. Xiao, H., Luo, K., Yang, S., Wang, Y. & Liang, W. (2002). Tissue tropism of the TTV in experimentally infected rhesus monkeys. Chin Med J (Engl) 115, 1088-1090.
36. Yoshida, H., Kato, N., Shiratori, Y., Lan, K. H., Ono-Nita, S. K., Feng, Z., Shii, S. & Omata, M. (2000). Poor association of TT virus viremia with hepatocellular carcinoma. Liver 20, 247-252.
37. Zhong, S., Yeo, W., Tang, M., Liu, C., Lin, X. R., Ho, W. M., Hui, P. & Johnson, P. (2002). Frequent detection of the replicative form of TT virus DNA in peripheral blood mononuclear cells and bone marrow cells in cancer patients. J Med Virol 66, 428-434.
38. Zhuang, S.-M., Shvarts, A., Van Ormondt, H., Jochemsen, A.-G., Van der Eb, A. J. & Noteborn, M. H. M. (1995). Apoptin, a protein derived from chicken anemia virus, induces a p53-independent apoptosis in human osteosarcoma cells. Cancer Res 55, 486-489.