Hypothermic circulatory arrest with and without cold selective antegrade cerebral perfusion: Impact on neurological recovery and tissue metabolism in an acute porcine model

European Journal of Cardio-thoracic Surgery

Volumn 26, Issue 1, 2004, Pages 73-80

  Hagl, Christian ^a   Khaladj, Nawid ^a   Peterss, Sven ^a   Hoeffler, Klaus ^a   Winterhalter, Michael ^a   Karck, Matthias ^a   Haverich, Axel ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Aortic surgery; Cerebral protection; Hypothermic circulatory arrest; Pig model; Selective antegrade cerebral perfusion

Indexed keywords

ACIDOSIS; ANIMAL MODEL; ANIMAL TISSUE; BRAIN PERFUSION; BRAIN TEMPERATURE; BRAIN TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; CONVALESCENCE; ELECTROENCEPHALOGRAM; EVOKED SOMATOSENSORY RESPONSE; FEMALE; HEART ARREST; HEMODYNAMIC MONITORING; HISTOPATHOLOGY; INDUCED HYPOTHERMIA; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; SPECTROSCOPY; SWINE; TISSUE METABOLISM;

ANIMALS; BRAIN EDEMA; CARBON DIOXIDE; CARDIOPULMONARY BYPASS; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; FEMALE; HEART ARREST, INDUCED; HEMODYNAMIC PROCESSES; HYPOTHERMIA, INDUCED; INTRACRANIAL PRESSURE; OXYGEN; RANDOM ALLOCATION; REPERFUSION INJURY; SWINE;

EID: 2942624376     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2004.04.002     Document Type: Conference Paper

References (16)

1. Griepp R.B. Cerebral protection during aortic arch surgery. J Thorac Cardiovasc Surg. 121:2001;425-427
2. Reich D.L., Uysal S., Ergin M.A., Griepp R.B. Retrograde cerebral perfusion as a method of neuroprotection during thoracic aortic surgery. Ann Thorac Surg. 72:2001;1774-1782
3. Hagl C., Khaladj N., Karck M., Kallenbach K., Leyh R., Winterhalter M., Haverich A. Hypothermic circulatory arrest during ascending and aortic arch surgery: the theoretical impact of different cerebral perfusion techniques and other methods of cerebral protection. Eur J Cardiothorac Surg. 24:2003;371-378
4. Di Eusanio M., Wesselink R.M., Morshuis W.J., Dossche K.M., Schepens M.A. Deep hypothermic circulatory arrest and antegrade selective cerebral perfusion during ascending aorta-hemiarch replacement: a retrospective comparative study. J Thorac Cardiovasc Surg. 125:2003;849-854
5. Hagl C., Ergin M.A., Galla J.D., Lansman S.L., McCullough J.N., Spielvogel D., Sfeir P., Bodian C.A., Griepp R.B. Neurologic outcome after ascending aorta-aortic arch operations: effect of brain protection technique in high-risk patients. J Thorac Cardiovasc Surg. 121:2001;1107-1121
6. Hagl C., Tatton N.A., Weisz D.J., Zhang N., Spielvogel D., Shiang H.H., Bodian C.A., Griepp R.B. Cyclosporine A as a potential neuroprotective agent: a study of prolonged hypothermic circulatory arrest in a chronic porcine model. Eur J Cardiothorac Surg. 19:2001;756-764
7. Dossche K.M., Morshuis W.J., Schepens M.A., Waanders F.G. Bilateral antegrade selective cerebral perfusion during surgery on the proximal thoracic aorta. Eur J Cardiothorac Surg. 17:2000;462-467
8. Kazui T., Kimura N., Yamada O., Komatsu S. Surgical outcome of aortic arch aneurysms using selective cerebral perfusion. Ann Thorac Surg. 57:1994;904-911
9. Bachet J., Guilmet B., Goudot B., Termignon G., Dreyfus G., Teodori G. Cold cerebroplegia. A new technique of cerebral protection during surgery of the transverse aortic arch. J Thorac Cardiovasc Surg. 102:1991;85-94
10. Mezrow C.K., Midulla P.S., Sadeghi A.M., Gandsas A., Wang W., Dapunt O.E., Zappulla R., Griepp R.B. Evaluation of cerebral metabolism and quantitative electroencephalography after hypothermic circulatory arrest and low-flow cardiopulmonary bypass at different temperatures. J Thorac Cardiovasc Surg. 107:1994;1006-1019
11. Hagl C., Tatton N.A., Khaladj N., Zhang N., Nandor S., Insolia S., Weisz D.J., Spielvogel D., Griepp R.B. Involvement of apoptosis in neurological injury after hypothermic circulatory arrest: a new target for therapeutic intervention? Ann Thorac Surg. 72:2001;1457-1464
12. Juvonen T., Zhang N., Wolfe D., Weisz D.J., Bodian C.A., Shiang H.H., McCullough J.N., Griepp R.B. Retrograde cerebral perfusion enhances cerebral protection during prolonged hypothermic circulatory arrest: a study in a chronic porcine model. Ann Thorac Surg. 66:1998;38-50
13. Strauch J.T., Spielvogel D., Haldenwang P.L., Zhang N., Weisz D., Bodian C., Griepp R.B. Hypothermic selective cerebral perfusion compared with hypothermic cardiopulmonary bypass on cerebral hemodynamics and metabolism. Eur J Cardio-Thoracic Surg. 24:2003;807-816
14. Ehrlich M.P., McCullough J., Wolfe D., Zhang N., Shiang H., Weisz D., Bodian G., Griepp R.B. Cerebral effects of cold reperfusion after hypothermic circulatory arrest. J Thorac Cardiovasc Surg. 121:2001;923-931
15. Hagl C., Khaladj N., Weisz D.J., Zhang N., Guo L.J., Bodian C.A., Spielvogel D., Griepp R.B. Impact of high intracranial pressure on neurophysiological recovery and behavior in a chronic porcine model of hypothermic circulatory arrest. Eur J Cardiothorac Surg. 22:2002;510-516
16. Ye J., Dai G., Ryner L.N., Kozlowski P., Yang L., Summers R., Sun J., Salerno T.A., Somorjai R.L., Deslauriers R. Unilateral antegrade cerebral perfusion through the right axillary artery provides uniform flow distribution to both hemispheres of the brain: a magnetic resonance and histopathological study in pigs. Circulation. 100:1999;II309-II315