Medical management of the pregnant patient with inflammatory bowel disease

Gastroenterology Clinics of North America

Volumn 33, Issue 2, 2004, Pages 361-385

  Steinlauf, Adam F ^a   Present, Daniel H ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOSALICYLIC ACID DERIVATIVE; ANTIBIOTIC AGENT; AZATHIOPRINE; BALSALAZIDE; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; CORTICOSTEROID; ERYTHROMYCIN; HYDROCORTISONE SODIUM SUCCINATE; IMMUNOSUPPRESSIVE AGENT; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; METHYLPREDNISOLONE SODIUM SUCCINATE; METRONIDAZOLE; PENICILLIN DERIVATIVE; PREDNISOLONE; PREDNISONE; PURINE DERIVATIVE; QUINOLONE DERIVATIVE; SALAZOSULFAPYRIDINE; TACROLIMUS;

ABDOMINAL PAIN; BRAIN HEMORRHAGE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONGENITAL MALFORMATION; DIARRHEA; DISEASE COURSE; ENTERITIS; FALLOT TETRALOGY; FERTILITY; FETUS DISEASE; GASTROINTESTINAL ENDOSCOPY; HUMAN; INFERTILITY; INHERITANCE; KERNICTERUS; LOW BIRTH WEIGHT; MUSCLE CRAMP; MUSCULOSKELETAL SYSTEM MALFORMATION; NAUSEA; NEURAL TUBE DEFECT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PREGNANCY; REVIEW; SIDE EFFECT; SPONTANEOUS ABORTION;

6-MERCAPTOPURINE; ADRENAL CORTEX HORMONES; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES, MONOCLONAL; AZATHIOPRINE; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATORY BOWEL DISEASES; PREGNANCY; PREGNANCY COMPLICATIONS;

EID: 2942624071     PISSN: 08898553     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gtc.2004.02.013     Document Type: Review

References (188)

1. Kane S. Managing pregnancy in IBD. Inflammatory Bowel Disease Monitor. 4:2002;2-11
2. Satsangi J., Jewell D.P., Rosenberg W.M., Bell J.I. Genetics of inflammatory bowel disease. Gut. 35:1994;696-700
3. Pavli P., Cavanaugh J., Grimm M. Inflammatory bowel disease: germs or genes? Lancet. 347:1996;1198
4. Orholm M., Binder V., Sorensen T.I., Rasmussen L.P., Kyvik K.O. Concordance of inflammatory bowel disease among Danish twins: results of a nationwide study. Scand J Gastroenterol. 35:2000;1075-1081
5. Tysk C., Lindberg E., Jarnerot G., Floderus-Myrhed B. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins: a study of heritability and the influence of smoking. Gut. 29:1988;990-996
6. Orholm M., Fonager K., Sorensen H.T. Risk of ulcerative colitis and Crohn's disease among offspring of patients with chronic inflammatory bowel disease. Am J Gastroenterol. 94:1999;3236-3238
7. Yang H., McElree M., Roth F., Shanahan S., Targan S., Rotter J. Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews. Gut. 34:1993;517-524
8. Halfvarson J., Bodin L., Tysk C., Lindberg E., Jarnerot G. Inflammatory bowel disease in a Swedish twin cohort: a long term follow-up of concordance and clinical characteristics. Gastroenterology. 124:2003;1767-1773
9. Bennett R.A., Rubin P.H., Present D.H. Frequency of inflammatory bowel disease in offspring of couples both presenting with inflammatory bowel disease. Gastroenterology. 100:1991;1638-1643
10. Sartor R.B. Clinical applications of advances in the genetics of IBD. Rev Gastroenterol Disord. 3:(Suppl 1):2003;S9-S17
11. Ogura Y., Inohara N., Benito A., Chen F.F., Yamaoka S., Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem. 276:2001;4812-4818
12. Inohara N., Ogura Y., Nunez G. Nods: a family of cytosolic proteins that regulate the host response to pathogens. Curr Opin Microbiol. 5:2002;76-80
13. Ahmad T., Armuzzi A., Bunce M., et al. The molecular classification of the clinical manifestations of Crohn's disease. Gastroenterology. 122:2002;854-866
14. Lesage S., Zouali H., Cezard J.P., et al. CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet. 70:2002;845-857
15. Alstead E.M. Inflammatory bowel disease in pregnancy. Postgrad Med J. 78:2002;23-26
16. Korelitz B.I. Inflammatory bowel disease and pregnancy. Gastroenterol Clin North Am. 27:1998;213-224
17. Moody G.A., Probert C., Jayanthi V., Mayberry J.F. The effects of chronic ill health and treatment with sulphasalazine on fertility amongst men and women with inflammatory bowel disease in Leicestershire. Int J Colorectal Dis. 12:1997;220-224
18. Subhani J.M., Hamiliton M.I. Review article: the management of inflammatory bowel disease during pregnancy. Aliment Pharmacol Ther. 12:1998;1039-1053
19. Moody G., Probert C.S., Srivastava E.M., Rhodes J., Mayberry J.F. Sexual dysfunction amongst women with Crohn's disease: a hidden problem. Digestion. 52:1992;179-183
20. Baird D.D., Narendranathan M., Sandler R.S. Increased risk of preterm birth for women with inflammatory bowel disease. Gastroenterology. 99:1990;987-994
21. Mayberry J.F., Weterman I.T. European survey of fertility and pregnancy in women with Crohn's disease: a case control study by European collaborative group. Gut. 27:1986;821-825
22. Willoughby C.P., Truelove S.C. Ulcerative colitis and pregnancy. Gut. 21:1980;469-474
23. Jarnerot G. Fertility, sterility, and pregnancy in chronic inflammatory bowel disease. Scand J Gastroenterol. 17:1982;1-4
24. Vender R.J., Spiro H.M. Inflammatory bowel disease and pregnancy. J Clin Gastroenterol. 4:1982;231-249
25. Tiainen J., Matikainen M., Hiltunen K.M. Ileal J-pouch-anal anastomosis, sexual dysfunction, and fertility. Scand J Gastroenterol. 34:1999;185-188
26. Wikland M., Jansson I., Asztely M., et al. Gynaecological problems related to anatomical changes after conventional proctocolectomy and ileostomy. Int J Colorectal Dis. 5:1990;49-52
27. Ravid A., Richard C.S., Spencer L.M., et al. Pregnancy, delivery, and pouch function after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum. 45:2002;1283-1288
28. Ording Olsen K., Juul S., Berndtsson I., Oresland T., Laurberg S. Ulcerative colitis: female fecundity before diagnosis, during disease, and after surgery compared with a population sample. Gastroenterology. 122:2002;15-19
29. Hudson M., Flett G., Sinclair T.S., Brunt P.W., Templeton A., Mowat N.A. Fertility and pregnancy in inflammatory bowel disease. Int J Gynaecol Obstet. 58:1997;229-237
30. Oresland T., Palmblad S., Ellstrom M., Berndtsson I., Crona N., Hulten L. Gynaecological and sexual function related to anatomical changes in the female pelvis after restorative proctocolectomy. Int J Colorectal Dis. 9:1994;77-81
31. Counihan T.C., Roberts P.L., Schoetz D.J. Jr., Coller J.A., Murray J.J., Veidenheimer M.C. Fertility and sexual and gynecologic function after ileal pouch-anal anastomosis. Dis Colon Rectum. 37:1994;1126-1129
32. Ravid A., Richard C., O'Connor B.I., et al. Fertility after ileal pouch-anal anastomosis in women with ulcerative colitis. [abstract] Gastroenterology. 120:(Suppl 1):2001;2417
33. Andersson R., Lambe M., Bergstrom R. Fertility patterns after appendectomy: historical cohort study. BMJ. 318:1999;963-967
34. Olsen K.O., Juul S., Bulow S., et al. Female fecundity before and after operation for familial adenomatous polyposis. Br J Surg. 90:2003;227-231
35. Juhasz E.S., Fozard B., Dozois R.R., Ilstrup D.M., Nelson H. Ileal pouch-anal anastomosis function following childbirth: an extended evaluation. Dis Colon Rectum. 38:1995;159-165
36. Damgaard B., Wettergren A., Kirkegaard P. Social and sexual function following ileal pouch-anal anastomosis. Dis Colon Rectum. 38:1995;286-289
37. Burakoff R. Fertility and pregnancy in inflammatory bowel disease. Kirsner J.B. Inflammatory bowel disease. 2000;372-378 WB Saunders, Philadelphia
38. Michelassi F., Stella M., Block G.E. Prospective assessment of functional results after ileal J pouch-anal restorative proctocolectomy. Arch Surg. 128:1993;889-894. [discussion: 894-5]
39. Johnson E., Carlsen E., Nazir M., Nygaard K. Morbidity and functional outcome after restorative proctocolectomy for ulcerative colitis. Eur J Surg. 167:2001;40-45
40. Khosla R., Willoughby C.P., Jewell D.P. Crohn's disease and pregnancy. Gut. 25:1984;52-56
41. Narendranathan M., Sandler R.S., Suchindran C.M., Savitz D.A. Male infertility in inflammatory bowel disease. J Clin Gastroenterol. 11:1989;403-406
42. Farthing M.J., Dawson A.M. Impaired semen quality in Crohn's disease: drugs, ill health, or undernutrition? Scand J Gastroenterol. 18:1983;57-60
43. Birnie G.G., McLeod T.I., Watkinson G. Incidence of sulphasalazine- induced male infertility. Gut. 22:1981;452-455
44. Levi A.J., Fisher A.M., Hughes L., Hendry W.F. Male infertility due to sulphasalazine. Lancet. 2:1979;276-278
45. Toth A. Reversible toxic effect of salicylazosulfapyridine on semen quality. Fertil Steril. 31:1979;538-540
46. Chatzinoff M., Guarino J.M., Corson S.L., Batzer F.R., Friedman L.S. Sulfasalazine-induced abnormal sperm penetration assay reversed on changing to 5-aminosalicylic acid enemas. Dig Dis Sci. 33:1988;108-110
47. Riley S.A., Lecarpentier J., Mani V., Goodman M.J., Mandal B.K., Turnberg L.A. Sulphasalazine induced seminal abnormalities in ulcerative colitis: results of mesalazine substitution. Gut. 28:1987;1008-1012
48. Zelissen P.M., van Hattum J., Poen H., Scholten P., Gerritse R., te Velde E.R. Influence of salazosulphapyridine and 5-aminosalicylic acid on seminal qualities and male sex hormones. Scand J Gastroenterol. 23:1988;1100-1104
49. Kjaergaard N., Christensen L.A., Lauritsen J.G., Rasmussen S.N., Hansen S.H. Effects of mesalazine substitution on salicylazosulfapyridine-induced seminal abnormalities in men with ulcerative colitis. Scand J Gastroenterol. 24:1989;891-896
50. Miller J.P. Inflammatory bowel disease in pregnancy: a review. J R Soc Med. 79:1986;221-225
51. Ferrero S., Ragni N. Inflammatory bowel disease: management issues during pregnancy. Arch Gynecol Obstet. 2003;. in press
52. Nielsen O.H., Andreasson B., Bondesen S., Jarnum S. Pregnancy in ulcerative colitis. Scand J Gastroenterol. 18:1983;735-742
53. Porter R.J., Stirrat G.M. The effects of inflammatory bowel disease on pregnancy: a case-controlled retrospective analysis. Br J Obstet Gynaecol. 93:1986;1124-1131
54. Mogadam M., Dobbins W.O. III, Korelitz B.I., Ahmed S.W. Pregnancy in inflammatory bowel disease: effect of sulfasalazine and corticosteroids on fetal outcome. Gastroenterology. 80:1981;72-76
55. Abramson D., Jenkelson I.R., Milner L.R. Pregnancy and colitis. Am J Obstet Gynecol. 61:1951;121-129
56. Banks B.M., Korelitz B.I., Zetzel L. The course of nonspecific ulcerative colitis: a review of twenty years experience and late results. Gastroenterology. 32:1957;983-1012
57. MacDougall I. Ulcerative colitis and pregnancy. Lancet. 2:1956;641-643
58. Nwokolo C.U., Tan W.C., Andrews H.A., Allan R.N. Surgical resections in parous patients with distal ileal and colonic Crohn's disease. Gut. 35:1994;220-223
59. Kane S. HLS disparity determines disease activity through pregnancy in women with IBD. [abstract] Gastroenterology. 114:1998;A1006
60. Castiglione F., Pignata S., Morace F., et al. Effect of pregnancy on the clinical course of a cohort of women with inflammatory bowel disease. Ital J Gastroenterol. 28:1996;199-204
61. Buyon J.P. The effects of pregnancy on autoimmune diseases. J Leukoc Biol. 63:1998;281-287
62. Baiocco P.J., Korelitz B.I. The influence of inflammatory bowel disease and its treatment on pregnancy and fetal outcome. J Clin Gastroenterol. 6:1984;211-216
63. Hanan I.M., Kirsner J.B. Inflammatory bowel disease in the pregnant woman. Clin Perinatol. 12:1985;669-682
64. Fedorkow D.M., Persaud D., Nimrod C.A. Inflammatory bowel disease: a controlled study of late pregnancy outcome. Am J Obstet Gynecol. 160:1989;998-1001
65. Present D.H. Pregnancy and inflammatory bowel disease. Bayless T.M., Hanauer S.B. Advanced therapy of inflammatory bowel disease. 2001;613-618 BC Decker, Hamilton, Ontario
66. Norgard B., Fonager K., Sorensen H.T., Olsen J. Birth outcomes of women with ulcerative colitis: a nationwide Danish cohort study. Am J Gastroenterol. 95:2000;3165-3170
67. Dominitz J.A., Young J.C., Boyko E.J. Outcomes of infants born to mothers with inflammatory bowel disease: a population-based cohort study. Am J Gastroenterol. 97:2002;641-648
68. Anderson J.B., Turner G.M., Williamson R.C. Fulminant ulcerative colitis in late pregnancy and the puerperium. J R Soc Med. 80:1987;492-494
69. Ooi B.S., Remzi F.H., Fazio V.W. Turnbull-Blowhole colostomy for toxic ulcerative colitis in pregnancy: report of two cases. Dis Colon Rectum. 46:2003;111-115
70. Bertschinger P., Himmelmann A., Risti B., Follath F. Cyclosporine treatment of severe ulcerative colitis during pregnancy. Am J Gastroenterol. 90:1995;330
71. Ishijima N., Ojima E., Tonouchi H., Suzuki H., Fukunishi S. Delivery of a normal newborn after intensive medical treatment for an acute exacerbation of ulcerative colitis during pregnancy: a case report. Surg Today. 29:1999;1257-1259
72. Larzilliere I., Beau P. Chronic inflammatory bowel disease and pregnancy: case control study. Gastroenterol Clin Biol. 22:1998;1056-1060
73. Fonager K., Sorensen H.T., Olsen J., Dahlerup J.F., Rasmussen S.N. Pregnancy outcome for women with Crohn's disease: a follow-up study based on linkage between national registries. Am J Gastroenterol. 93:1998;2426-2430
74. Brent R.L. The effect of embryonic and fetal exposure to x-ray, microwaves, and ultrasound: counseling the pregnant and nonpregnant patient about these risks. Semin Oncol. 16:1989;347-368
75. Hall E.J. Scientific view of low-level radiation risks. Radiographics. 11:1991;509-518
76. Toppenberg K.S., Hill D.A., Miller D.P. Safety of radiographic imaging during pregnancy. Am Fam Physician. 59:1999;1813-1818. 1820
77. Hufton A.P. Radiation dose to the fetus in obstetric radiography. Br J Radiol. 52:1979;735-740
78. Moore M.M., Shearer D.R. Fetal dose estimates for CT pelvimetry. Radiology. 171:1989;265-267
79. Brent R.L., Meistrich M., Paul M. Ionizing and nonioinizing radiations. Paul M. Occupational and environmental reproductive hazards: a guide for clinicians. 1993;169-189 Williams & Wilkins, Baltimore
80. Nicklas A.H., Baker M.E. Imaging strategies in the pregnant cancer patient. Semin Oncol. 27:2000;623-632
81. Garden A.S., Weindling A.M., Griffiths R.D., Martin P.A. Fast-scan magnetic resonance imaging of fetal anomalies. Br J Obstet Gynaecol. 98:1991;1217-1222
82. Cappell M.S., Sidhom O. Multicenter, multiyear study of safety and efficacy of flexible sigmoidoscopy during pregnancy in 24 females with follow-up of fetal outcome. Dig Dis Sci. 40:1995;472-479
83. Cappell M.S., Colon V.J., Sidhom O.A. A study at 10 medical centers of the safety and efficacy of 48 flexible sigmoidoscopies and 8 colonoscopies during pregnancy with follow-up of fetal outcome and with comparison to control groups. Dig Dis Sci. 41:1996;2353-2361
84. Cappell M.S., Colon V.J., Sidhom O.A. A study of eight medical centers of the safety and clinical efficacy of esophagogastroduodenoscopy in 83 pregnant females with follow-up of fetal outcome with comparison control groups. Am J Gastroenterol. 91:1996;348-354
85. Connell W., Miller A. Treating inflammatory bowel disease during pregnancy: risks and safety of drug therapy. Drug Saf. 21:1999;311-323
86. Khan A.K., Truelove S.C. Placental and mammary transfer of sulphasalazine. BMJ. 2:1979;1553
87. Jarnerot G., Into-Malmberg M.B. Sulphasalazine treatment during breast feeding. Scand J Gastroenterol. 14:1979;869-871
88. Esbjorner E., Jarnerot G., Wranne L. Sulphasalazine and sulphapyridine serum levels in children to mothers treated with sulphasalazine during pregnancy and lactation. Acta Paediatr Scand. 76:1987;137-142
89. Singleton J.W., Hanauer S.B., Gitnick G.L., et al. Mesalamine capsules for the treatment of active Crohn's disease: results of a 16-week trial. Pentasa Crohn's Disease Study Group. Gastroenterology. 104:1993;1293-1301
90. Trallori G., d'Albasio G., Bardazzi G., et al. 5-Aminosalicylic acid in pregnancy: clinical report. Ital J Gastroenterol. 26:1994;75-78
91. Habal F.M., Hui G., Greenberg G.R. Oral 5-aminosalicylic acid for inflammatory bowel disease in pregnancy: safety and clinical course. Gastroenterology. 105:1993;1057-1060
92. Diav-Citrin O., Park Y.H., Veerasuntharam G., et al. The safety of mesalamine in human pregnancy: a prospective controlled cohort study. Gastroenterology. 114:1998;23-28
93. Marteau P., Tennenbaum R., Elefant E., Lemann M., Cosnes J. Foetal outcome in women with inflammatory bowel disease treated during pregnancy with oral mesalazine microgranules. Aliment Pharmacol Ther. 12:1998;1101-1108
94. Norgard B., Fonager K., Pedersen L., Jacobsen B.A., Sorensen H.T. Birth outcome in women exposed to 5-aminosalicylic acid during pregnancy: a Danish cohort study. Gut. 52:2003;243-247
95. Present D.H. How to do without steroids in inflammatory bowel disease. Inflamm Bowel Dis. 6:2000;48-57
96. Burtin P., Taddio A., Ariburnu O., Einarson T.R., Koren G. Safety of metronidazole in pregnancy: a meta-analysis. Am J Obstet Gynecol. 172:1995;525-529
97. Caro-Paton T., Carvajal A., Martin de Diego I., Martin-Arias L.H., Alvarez Requejo A., Rodriguez Pinilla E. Is metronidazole teratogenic? A meta-analysis. Br J Clin Pharmacol. 44:1997;179-182
98. Czeizel A.E., Rockenbauer M. A population based case-control teratologic study of oral metronidazole treatment during pregnancy. Br J Obstet Gynaecol. 105:1998;322-327
99. Diav-Citrin O., Shechtman S., Gotteiner T., Arnon J., Ornoy A. Pregnancy outcome after gestational exposure to metronidazole: a prospective controlled cohort study. Teratology. 63:2001;186-192
100. Piper J.M., Mitchel E.F., Ray W.A. Prenatal use of metronidazole and birth defects: no association. Obstet Gynecol. 82:1993;348-352
101. Rosa F.W., Baum C., Shaw M. Pregnancy outcomes after first-trimester vaginitis drug therapy. Obstet Gynecol. 69:1987;751-755
102. Friedman J., Polifka J. Teratogenic effects of drugs: a resource for clinicians (TERIS). 2000;Johns Hopkins University Press, Baltimore. p. 149-95
103. Loebstein R., Addis A., Ho E., et al. Pregnancy outcome following gestational exposure to fluoroquinolones: a multicenter prospective controlled study. Antimicrob Agents Chemother. 42:1998;1336-1339
104. Schaefer C., Amoura-Elefant E., Vial T., et al. Pregnancy outcome after prenatal quinolone exposure: evaluation of a case registry of the European Network of Teratology Information Services (ENTIS). Eur J Obstet Gynecol Reprod Biol. 69:1996;83-89
105. Berkovitch M., Pastuszak A., Gazarian M., Lewis M., Koren G. Safety of the new quinolones in pregnancy. Obstet Gynecol. 84:1994;535-538
106. Brumfitt W., Pursell R. Trimethoprim-sulfamethoxazole in the treatment of bacteriuria in women. J Infect Dis. 128:1973;657-665
107. DeCosta E.J., Abelman M.A. Cortisone and pregnancy: an experimental and clinical study of the effects of cortisone on gestation. Am J Obstet Gynecol. 64:1952;746-767
108. Koren G., Pastuszak A., Ito S. Drugs in pregnancy. N Engl J Med. 338:1998;1128-1137
109. Norjavaara E., de Verdier M.G. Normal pregnancy outcomes in a population-based study including 2, 968 pregnant women exposed to budesonide. J Allergy Clin Immunol. 111:2003;736-742
110. Kallen B., Rydhstroem H., Aberg A. Congenital malformations after the use of inhaled budesonide in early pregnancy. Obstet Gynecol. 93:1999;392-395
111. Beitins I.Z., Bayard F., Ances I., Kowarski A., Migeon C.G. The transplacental passage of prednisone and prednisolone in pregnancy near term. J Pediatr. 81:1972;936-945
112. Ost L., Wettrell G., Bjorkhem I., Rane A. Prednisolone excretion in human milk. J Pediatr. 106:1985;1008-1011
113. Bermas B.L., Hill J.A. Effects of immunosuppressive drugs during pregnancy. Arthritis Rheum. 38:1995;1722-1732
114. Blatt J., Mulvihill J.J., Ziegler J.L., Young R.C., Poplack D.G. Pregnancy outcome following cancer chemotherapy. Am J Med. 69:1980;828-832
115. Nicholson H.O. Cytotoxic drugs in pregnancy: review of reported cases. J Obstet Gynaecol Br Commonw. 75:1968;307-312
116. Platzek T., Bochert G. Dose-response relationship of teratogenicity and prenatal-toxic risk estimation of 6-mercaptopurine riboside in mice. Teratog Carcinog Mutagen. 16:1996;169-181
117. Voogd C.E. Azathioprine, a genotoxic agent to be considered non-genotoxic in man. Mutat Res. 221:1989;133-152
118. Mosesso P., Palitti F. The genetic toxicology of 6-mercaptopurine. Mutat Res. 296:1993;279-294
119. Meehan R.T., Dorsey J.K. Pregnancy among patients with systemic lupus erythematosus receiving immunosuppressive therapy. J Rheumatol. 14:1987;252-258
120. Scantlebury V., Gordon R., Tzakis A., et al. Childbearing after liver transplantation. Transplantation. 49:1990;317-321
121. Roubenoff R., Hoyt J., Petri M., Hochberg M.C., Hellmann D.B. Effects of antiinflammatory and immunosuppressive drugs on pregnancy and fertility. Semin Arthritis Rheum. 18:1988;88-110
122. Williamson R.A., Karp L.E. Azathioprine teratogenicity: review of the literature and case report. Obstet Gynecol. 58:1981;247-250
123. Rayburn W.F. Connective tissue disorders and pregnancy: recommendations for prescribing. J Reprod Med. 43:1998;341-349
124. Hou S. Pregnancy in women with chronic renal disease. N Engl J Med. 312:1985;836-839
125. Hou S. Pregnancy in chronic renal insufficiency and end-stage renal disease. Am J Kidney Dis. 33:1999;235-252
126. Willis F.R., Findlay C.A., Gorrie M.J., Watson M.A., Wilkinson A.G., Beattie T.J. Children of renal transplant recipient mothers. J Paediatr Child Health. 36:2000;230-235
127. Ghandour F.Z., Knauss T.C., Hricik D.E. Immunosuppressive drugs in pregnancy. Adv Ren Replace Ther. 5:1998;31-37
128. Alstead E.M., Ritchie J.K., Lennard-Jones J.E., Farthing M.J., Clark M.L. Safety of azathioprine in pregnancy in inflammatory bowel disease. Gastroenterology. 99:1990;443-446
129. Dejaco C., Mittermaier C., Reinisch W., et al. Azathioprine treatment and male fertility in inflammatory bowel disease. Gastroenterology. 121:2001;1048-1053
130. Rajapakse R.O., Korelitz B.I., Zlatanic J., Baiocco P.J., Gleim G.W. Outcome of pregnancies when fathers are treated with 6-mercaptopurine for inflammatory bowel disease. Am J Gastroenterol. 95:2000;684-688
131. Francella A., Dyan A., Bodian C., Rubin P., Chapman M., Present D.H. The safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study. Gastroenterology. 124:2003;9-17
132. Zlatanic J., Korelitz B.I., Rajapakse R., et al. Complications of pregnancy and child development after cessation of treatment with 6-mercaptopurine for inflammatory bowel disease. J Clin Gastroenterol. 36:2003;303-309
133. Friedman S., Regueiro M.D. Pregnancy and nursing in inflammatory bowel disease. Gastroenterol Clin North Am. 31:2002;265-273
134. Lichtiger S., Present D.H., Kornbluth A., et al. Cyclosporine in severe ulcerative colitis refractory to steroid therapy. N Engl J Med. 330:1994;1841-1845
135. Egan L.J., Sandborn W.J., Tremaine W.J. Clinical outcome following treatment of refractory inflammatory and fistulizing Crohn's disease with intravenous cyclosporine. Am J Gastroenterol. 93:1998;442-448
136. Hanauer S.B., Shulman M.I. New therapeutic approaches. Gastroenterol Clin North Am. 24:1995;523-540
137. Present D.H., Lichtiger S. Efficacy of cyclosporine in treatment of fistula of Crohn's disease. Dig Dis Sci. 39:1994;374-380
138. Armenti V.T., Ahlswede K.M., Ahlswede B.A., Jarrell B.E., Moritz M.J., Burke J.F. National transplantation Pregnancy Registry: outcomes of 154 pregnancies in cyclosporine-treated female kidney transplant recipients. Transplantation. 57:1994;502-506
139. Armenti V.T., Jarrell B.E., Radomski J.S., McGrory C.H., Gaughan W.J., Moritz M.J. National Transplantation Pregnancy Registry (NTPR): cyclosporine dosing and pregnancy outcome in female renal transplant recipients. Transplant Proc. 28:1996;2111-2112
140. Radomski J.S., Ahlswede B.A., Jarrell B.E., et al. Outcomes of 500 pregnancies in 335 female kidney, liver, and heart transplant recipients. Transplant Proc. 27:1995;1089-1090
141. al-Khader A.A., Absy M., al-Hasani M.K., Joyce B., Sabbagh T. Successful pregnancy in renal transplant recipients treated with cyclosporine. Transplantation. 45:1988;987-988
142. Bar Oz B., Hackman R., Einarson T., Koren G. Pregnancy outcome after cyclosporine therapy during pregnancy: a meta-analysis. Transplantation. 71:2001;1051-1055
143. Marion J.F., Rubin P.H., Lichtiger S., Chapman M.L., Hanauer S., Present D.H. Cyclosporine is safe for severe colitis complicating pregnancy. [abstract] Am J Gastroenterol. 91:1996;1975
144. Bousvaros A., Kirschner B.S., Werlin S.L., et al. Oral tacrolimus treatment of severe colitis in children. J Pediatr. 137:2000;794-799
145. Sandborn W.J. Preliminary report on the use of oral tacrolimus (FK506) in the treatment of complicated proximal small bowel and fistulizing Crohn's disease. Am J Gastroenterol. 92:1997;876-879
146. Lowry P.W., Weaver A.L., Tremaine W.J., Sandborn W.J. Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment-refractory Crohn's disease perianal fistulae. Inflamm Bowel Dis. 5:1999;239-245
147. Fellermann K., Herrlinger K.R., Witthoeft T., Homann N., Ludwig D., Stange E.F. Tacrolimus: a new immunosuppressant for steroid refractory inflammatory bowel disease. Transplant Proc. 33:2001;2247-2248
148. Jain A., Venkataramanan R., Lever J., et al. FK506 and pregnancy in liver transplant patients. Transplantation. 56:1993;1588-1589
149. Winkler M.E., Niesert S., Ringe B., Pichlmayr R. Successful pregnancy in a patient after liver transplantation maintained on FK 506. Transplantation. 56:1993;1589-1590
150. Jain A., Venkataramanan R., Fung J.J., et al. Pregnancy after liver transplantation under tacrolimus. Transplantation. 64:1997;559-565
151. Armenti V.T., Moritz M.J., Davison J.M. Drug safety issues in pregnancy following transplantation and immunosuppression: effects and outcomes. Drug Saf. 19:1998;219-232
152. Kainz A., Harabacz I., Cowlrick I.S., Gadgil S.D., Hagiwara D. Review of the course and outcome of 100 pregnancies in 84 women treated with tacrolimus. Transplantation. 70:2000;1718-1721
153. Feagan B.G., Rochon J., Fedorak R.N., et al. Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators. N Engl J Med. 332:1995;292-297
154. Goldenberg M., Bider D., Admon D., Mashiach S., Oelsner G. Methotrexate therapy of tubal pregnancy. Hum Reprod. 8:1993;660-666
155. Kozlowski R.D., Steinbrunner J.V., MacKenzie A.H., Clough J.D., Wilke W.S., Segal A.M. Outcome of first-trimester exposure to low-dose methotrexate in eight patients with rheumatic disease. Am J Med. 88:1990;589-592
156. Alstead E.M., Nelson-Piercy C. Inflammatory bowel disease in pregnancy. Gut. 52:2003;159-161
157. Targan S.R., Hanauer S.B., van Deventer S.J., et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med. 337:1997;1029-1035
158. Present D.H., Rutgeerts P., Targan S., et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med. 340:1999;1398-1405
159. Rutgeerts P., D'Haens G., Targan S., et al. Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease. Gastroenterology. 117:1999;761-769
160. Hanauer S.B., Feagan B.G., Lichtenstein G.R., et al. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet. 359:2002;1541-1549
161. Srinivasan R. Infliximab treatment and pregnancy outcome in active Crohn's disease. Am J Gastroenterol. 96:2001;2274-2275
162. Katz J.A., Lichtenstein G.R., Keenan G.F., Healy D.E., Jacobs S.J. Outcome of pregnancy in women receiving REMICADE (infliximab) for the treatment of Crohn's disease or rheumatoid arthritis. Gastroenterology. 120:2001;A69
163. Vasiliauskas E.A., Kam L.Y., Abreu-Martin M.T., et al. An open-label pilot study of low-dose thalidomide in chronically active, steroid-dependent Crohn's disease. Gastroenterology. 117:1999;1278-1287
164. Ehrenpreis E.D., Kane S.V., Cohen L.B., Cohen R.D., Hanauer S.B. Thalidomide therapy for patients with refractory Crohn's disease: an open-label trial. Gastroenterology. 117:1999;1271-1277
165. Calabrese L., Fleischer A.B. Thalidomide: current and potential clinical applications. Am J Med. 108:2000;487-495
166. Manson J.M. Teratogenicity. Cassarett and Coull's toxicology: the basic science of poisons. 1986;MacMillan Publishing, New York. p. 195-220
167. Smithells R.W., Newman C.G. Recognition of thalidomide defects. J Med Genet. 29:1992;716-723
168. Albibi R., McCallum R.W. Metoclopramide: pharmacology and clinical application. Ann Intern Med. 98:1983;86-95
169. Harrington R.A., Hamilton C.W., Brogden R.N., Linkewich J.A., Romankiewicz J.A., Heel R.C. Metoclopramide: an updated review of its pharmacological properties and clinical use. Drugs. 25:1983;451-494
170. Buttino L. Jr., Coleman S.K., Bergauer N.K., Gambon C., Stanziano G.J. Home subcutaneous metoclopramide therapy for hyperemesis gravidarum. J Perinatol. 20:2000;359-362
171. Baron T.H., Ramirez B., Richter J.E. Gastrointestinal motility disorders during pregnancy. Ann Intern Med. 118:1993;366-375
172. 6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study. Obstet Gynecol. 78:1991;33-36
173. Siu S.S., Yip S.K., Cheung C.W., Lau T.K. Treatment of intractable hyperemesis gravidarum by ondansetron. Eur J Obstet Gynecol Reprod Biol. 105:2002;73-74
174. Tincello D.G., Johnstone M.J. Treatment of hyperemesis gravidarum with the 5-HT3 antagonist ondansetron (Zofran). Postgrad Med J. 72:1996;688-689
175. Sullivan C.A., Johnson C.A., Roach H., Martin R.W., Stewart D.K., Morrison J.C. A pilot study of intravenous ondansetron for hyperemesis gravidarum. Am J Obstet Gynecol. 174:1996;1565-1568
176. Larson J.D., Patatanian E., Miner P.B. Jr., Rayburn W.F., Robinson M.G. Double-blind, placebo-controlled study of ranitidine for gastroesophageal reflux symptoms during pregnancy. Obstet Gynecol. 90:1997;83-87
177. Nikfar S., Abdollahi M., Moretti M.E., Magee L.A., Koren G. Use of proton pump inhibitors during pregnancy and rates of major malformations: a meta-analysis. Dig Dis Sci. 47:2002;1526-1529
178. Stuart M.J., Gross S.J., Elrad H., Graeber J.E. Effects of acetylsalicylic-acid ingestion on maternal and neonatal hemostasis. N Engl J Med. 307:1982;909-912
179. Gladman D., Urowitz M. Rheumatic disease in pregnancy. Duffy B.A. Medical complications during pregnancy. 1999;415-438 WB Saunders, Philadelphia
180. Mela M., Mancuso A., Burroughs A.K. Review article: pruritus in cholestatic and other liver diseases. Aliment Pharmacol Ther. 17:2003;857-870
181. Koch K.L., Stern R.M., Vasey M., Botti J.J., Creasy G.W., Dwyer A. Gastric dysrhythmias and nausea of pregnancy. Dig Dis Sci. 35:1990;961-968
182. Heinonen O.P., Stone D., Shapiro S. Birth defects and drugs in pregnancy. 1977;Publishing Sciences Group, Littleton, MA
183. McEwan H.P. Ulcerative colitis in pregnancy. Proc R Soc Med. 65:1972;279-281
184. Bohe M.G., Ekelund G.R., Genell S.N., et al. Surgery for fulminating colitis during pregnancy. Dis Colon Rectum. 26:1983;119-122
185. Boulton R., Hamilton M., Lewis A., Walker P., Pounder R. Fulminant ulcerative colitis in pregnancy. Am J Gastroenterol. 89:1994;931-933
186. Scott H.J., McLeod R.S., Blair J., O'Connor B., Cohen Z. Ileal pouch-anal anastomosis: pregnancy, delivery and pouch function. Int J Colorectal Dis. 11:1996;84-87
187. Brandt L.J., Estabrook S.G., Reinus J.F. Results of a survey to evaluate whether vaginal delivery and episiotomy lead to perineal involvement in women with Crohn's disease. Am J Gastroenterol. 90:1995;1918-1922
188. Moss D.G. Fertility and pregnancy in inflammatory bowel disease. Bayless T.M., Hanauer S.B. Advanced therapy of inflammatory bowel disease. 2001;607-611 BC Decker, Hamilton, Ontario