Comparison of several combinations of free, complexed, and total PSA in the diagnosis of prostate cancer in patients with urologic symptoms

Urology

Volumn 63, Issue 6, 2004, Pages 1100-1103

  Filella, Xavier ^a   Truan, David ^b   Alcover, Joan ^b   Quintó, Llorenç ^b   Molina, Rafael ^b   Luque, Pilar ^b   Coca, Francisca ^b   Ballesta, Antonio M ^b  

^a HOSPITAL CLÍNIC   (Spain)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; RECEIVER OPERATING CHARACTERISTIC; SYMPTOM; UROLOGY;

AGED; AREA UNDER CURVE; BIOPSY; DIAGNOSIS, DIFFERENTIAL; HUMANS; MALE; PALPATION; PREDICTIVE VALUE OF TESTS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; REGRESSION ANALYSIS; ROC CURVE; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 2942613057     PISSN: 00904295     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.urology.2004.01.056     Document Type: Article

References (18)

1. Ambruster D.A. Prostate-specific antigen biochemistry, analytical methods, and clinical application. Clin Chem. 39:1993;181-195
2. Filella X., Molina R., Ballesta A.M., et al. Value of PSA (prostate-specific antigen) in the detection of prostate cancer in patients with urological symptoms results of a multicentre study. Eur J Cancer. 32A:1996;1125-1128
3. Benson M.C., Whang I.S., Pantuck A., et al. Prostate specific antigen density a means of distinguishing benign prostatic hypertrophy and prostate cancer. J Urol. 147:1992;815-816
4. Carter H.B., Pearson J.D., Metter E.J., et al. Longitudinal evaluation of prostate specific antigen levels in men with and without prostate disease. JAMA. 267:1991;2215-2220
5. Oesterling J.E. Age-specific ranges for serum PSA. N Engl J Med. 335:1996;345-346
6. Woodrum D.L., Brawer M.K., Partin A.W., et al. Interpretation of free prostate specific antigen clinical research studies for the detection of prostate cancer. J Urol. 159:1998;5-12
7. Li P.E., Lange P.H. Free and total PSA. Brawer M.K. Prostate Specific Antigen. 2001;91-117 Marcel Dekker, New York
8. Allard W.J., Zhou Z., Yeung K.K. Novel immunoassay for the measurement of complexed prostate-specific antigen in serum. Clin Chem. 44:1998;1216-1223
9. Brawer M.K., Meyer G.E., Letran J.L., et al. Measurement of complexed PSA improves specificity for early detection of prostate cancer. Urology. 52:1998;372-378
10. Partin A.W., Catalona W.J., Southwick P.C., et al. Analysis of percent free prostate-specific antigen (PSA) for prostate cancer detection influence of total PSA, prostate volume, and age. Urology. 48:1996;55-61
11. Filella X., Alcover J., Molina R., et al. Free and total PSA in the diagnosis of prostate cancer. Tumor Biol. 18:1997;332-340
12. Ellison L., Cheli C.D., Bright S.,. Cost-benefit analysis of total, free/total, and complexed prostate-specific antigen for prostate cancer screening. Urology. 60:(suppl 1):2002;42-46
13. Djavan B., Remzi M., Zlotta A.R. Complexed prostate-specific antigen, complexed prostate-specific antigen density of total and transition zone, complexed/total prostate-specific antigen ratio, free-to-total prostate-specific antigen ratio, density of total and transition zone prostate-specific antigen results of the prospective multicenter European trial. Urology. 60:(suppl 1):2002;4-9
14. Filella X., Alcover J., Molina R., et al. Measurement of complexed PSA in the differential diagnosis between prostate cancer and benign prostate hyperplasia. Prostate. 42:2000;181-185
15. Jung K., Brux B., Knäbich A., et al. A gap between total prostate-specific antigen and the sum of free prostate-specific antigen plus α1-antichymotrypsin-prostate-specific antigen in patients with prostate carcinoma but not in those with benign prostate hyperplasia. Clin Chem. 45:1999;422-424
16. Lein M., Jung K., Elgeti U., et al. Comparison of the clinical validity of free prostate-specific antigen, alpha-1 antichymotrypsin-bound prostate-specific antigen and complexed prostate-specific antigen in prostate cancer diagnosis. Eur Urol. 39:2001;57-64
17. Wu J.T., Liu G.H. Advantages of replacing the total PSA assay with the assay for PSA-alpha-1-antichymotrypsin complex for the screening and management of prostate cancer. J Clin Lab Anal. 12:1998;32-40
18. Filella X., Alcover J., Corral J.M., et al. Free and complexed PSA ratio in differentiating benign prostate hyperplasia from prostate cancer. Anticancer Res. 21:2001;3717-3720