Native low density lipoprotein-induced calcium transients trigger VCAM- 1 and E-selectin expression in cultured human vascular endothelial cells

Journal of Clinical Investigation

Volumn 101, Issue 5, 1998, Pages 1064-1075

  Allen, Sean ^a   Khan, Shabeena ^a   Futwan Al Mohanna, ^b   Batten, Puspa ^a   Yacoub, Magdi ^a  

^a HAREFIELD HOSPITAL   (United Kingdom)

^b KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

Endothelium; Integrins; N LDL; Selectins; Signaling

Indexed keywords

1,2 BIS(1 AMINOPHENOXY)ETHANE N,N,N',N' TETRAACETIC ACETOMETHYL ESTER; CALCIUM CHELATING AGENT; CALCIUM ION; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; IMMUNOGLOBULIN G ANTIBODY; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; RECEPTOR ANTIBODY; RECEPTOR ANTIBODY IGG C7; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; ATHEROGENESIS; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SECOND MESSENGER; VASCULAR ENDOTHELIUM;

EID: 0032032347     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI445     Document Type: Article

References (60)

1. Steinberg, D., and J.L. Witztum. 1990. Lipoproteins and atherogenesis: current concepts. JAMA (J. Am. Med. Assoc.). 264:3047-3052.
2. Scandinavian Simvastatin Survival Group. 1994. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study. Lancet. 344:1383-1389.
3. Shepherd, J., S. Cobbe, I. Ford, C.G Isles, A.R. Lorimer, P.W. Macfarlane, and J.H. McKillop. 1995. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N. Engl. J. Med. 333:1301-1307.
4. Faruqi, R.M., and P.E. DiCorleto. 1993. Mechanisms of monocyte recruitment and accumulation. Br. Heart. J. 69:S19-S29.
5. Parthasarathy, S., D. Steinberg, and J.L. Witzlum. 1992. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis. Annu. Rev. Med. 43:219-225.
6. Yla-Herttuala, S., M.E. Rosenfeld, S. Parthasarathy, E. Sigal, T. Sarkioja, J.L. Witztum, and D. Steinberg. 1991. Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl LDL receptor mRNA colocalize with oxidation specific lipid-protein adducts. J. Clin. Invest. 87:1146-1152.
7. Brown, M.S., S.K. Basu, J.R. Falck, Y.K. Ho, and J.L. Goldstein. 1980. The scavenger cell pathway for lipoprotein degradation: specificity of binding site that mediate the uptake of negatively charged LDL by macrophages. J. Supramol. Struct. 13:67-81.
8. McEver, R.P. 1992. Leukocyte-endothelial interactions. Curr. Opin. Cell. Biol. 4:840-849.
9. Murohara, T., R. Scalia, and A.M. Lefer. 1996. Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells: possible involvement of protein kinase C activation and its inhibition by nitric oxide donors. Circ. Res. 78:780-789.
10. Mehta, A., B. Yang, S. Khan, J.B. Hendricks, C. Stephen, and J.L. Mehta. 1995. Oxidized low-density lipoproteins facilitate leukocyte adhesion to aortic intima without affecting endothelium-dependent relaxation: role of P-selectin. Arterioscler. Thromb. Vasc. Biol. 15:2076-2083.
11. Li, H., M.I. Cybulsky, M.A. Gimbrone, Jr., and P.A. Lihby. 1993. An atherogenic diet rapidly induces VCAM-1, a cytokine regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelial cells. Arterioscler. Thromb. Vasc. Biol. 13:197-204.
12. Gushing, S.D., J.A. Berliner, A.J. Valente, M.C. Territo, M. Navab, F. Parhami, R. Gerrity, C.J. Schwartz, and A.M. Fogelman. 1990. Minimally modified LDL induces monocyte chemotactic protein 1 in human endothelial and smooth muscle cells. Proc. Nat. Acad. Sci. USA. 87:5134-5138.
13. Rajavashisth, T.B., A. Andalibi, M.C. Territo, J.A. Berliner, M. Navab, A.M. Fogelman, and A.J. Lusis. 1990. Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified lowdensity lipoproteins. Nature. 344:254-257.
14. Strickberger, S.A., L.N. Russek, and R.D. Phair. 1988. Evidence for increased aortic plasma membrane calcium transport caused by experimental atherosclerosis in rabbit. Circ Res. 62:75-80.
15. Henry, P.D., and K.I. Bentley. 1981. Suppression of atherogenesis in cholesterol-fed rabbits treated with nifedipine. J. Clin. Invest. 68:1366-1369.
16. Smirnov, V.N., T.A. Voyno-Yasenetskaya, A.S. Antonov, M.E. Lukashev, V.P. Shirinsky, T.T. Tertov, and V.A. Tkachuk. 1990. Vascular signal transduction and atherosclerosis. Ann. NY Acad. Sci. 598:167-181.
17. Negre-Salvaryre, A., G. Fitoussi, V. Reaud, M.T. Pieraggi, J.C. Thiers, and R. Salvayre. 1992. A delayed and sustained rise of cylosolic calcium is elicited by oxidised low-density lipoprotein in cultured bovine aortic endothelial cells. FEBS Lett. 299:60-65.
18. Schaefer, H.I.M.P., K.M. Hold, J.M. Egas-Kenniphaas, and A. van der Laarse. 1993. Intracellular calcium signaling after binding of low-density lipoprotein to confluent and non-confluent cultures of an endothelial cell line, EA.hy926. Cell. Calcium. 14:507-516.
19. Phair, R.D. 1988. Cellular calcium and atherosclerosis. Cell. Calcium. 9: 275-284.
20. Al-Mohanna, F.A.A., K.S. Collison, R.S. Parhar, A.A. Kwaasi, B. Meyer, S. Saleh, S. Allen, S.T. Al-Sedairy, D. Stern, and M. Yacoub. 1997. Activation of naive xenogeneic but not allogeneic endothelial cells by human naive neutrophils: a potential occult barrier to xenotransplantation. Am. J. Pathol. 151:111-120.
21. Batten, P., M.H. Yacoub, and M.L. Rose. 1995. Effect of human cytokines (IFN-γ. TNF-α IL-1β IL-4) on porcine endothelial cells: induction of MHC and adhesion molecules and functional significance of these changes. Immunology. 87:127-133.
22. Rudel, L.L., J.A. Lee, M.D. Morris, and J.M. Felts. 1974. Characterization of plasma lipoprotein separated and purified by agarose-column chromatography. Biochem. J. 139:89-95.
23. Rubenstein, B., S. Evans, and G. Steiner. 1977. A new method for the fractionation of human plasma high density lipoprotein. Can. J. Biochem. 55: 766-768.
24. Collison, K.S., A.A. Kwaasi, R.S. Parhar, S.T. Al-Sedairy, and F.A.A. Al-Mohanna. 1995. Monomeric human IgE evokes a transient calcium rise in individual human neutrophils. J. Leuk. Biol. 58:459-467.
25. Pritchard, K.A., Jr., R.R. Tota, J. Lin, K.J. Danishefsky, B.A. Kurilla, J.A. Holland, and M.B. Stemerman. 1991. Native low-density lipoprotein: endothelial cell recruitment of mononuclear cells. Arterioscler. Thromb. 11:1175-1181.
26. Smalley, D.M., J.H.C. Lin, M.L. Curtis, Y. Kobari, M.B. Stemerman, and K.A. Pritchard, Jr. 1996. Native LDL increases endothelial cell adhesiveness by inducing intercellular adhesion molecule-1. Arterioscler. Thromb. Vasc. Biol. 16:585-590.
27. Marlor, M., D.L. Webb, M.P. Bombara, J.M. Greve, and M.L. Blue. 1992. Expression of vascular cell adhesion molecule-1 in fibroblast synoviocytes after stimulation with tumor necrosis factor. Am. J. Pathol. 140:1055-1060.
28. Beisiegel, U., W.J. Schneider, J.L. Goldstein, R.G.W. Anderson, and M.S. Brown. 1981. Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia. J. Biol. Chem. 256:11923-11931.
29. Morita, R., S. Morimoto, E. Koh, F. Keisuke, K. Shouei, I. Kazuyuki, T. Kazuhisa, O. Toshio, and O. Toshio. 1989. Low-density lipoprotein and apo protein B induce increases in inositol triphosphate and cytosolic free calcium via pertussis toxin sensitive GTP-binding protein in vascular smooth muscle cells. Biochem. Int. 18:647-653.
30. Kiss, Z. 1990. Effects of phorbol esters on phospholipid metabolism. Prog. Lipid. Res. 29:141-166.
31. Wolf, M., H. Levine III, W.S. May, Jr., P. Cuatrecasas, and N. Sahyoun. 1985. Role of intracellular calcium mobilization in the regulation of protein kinase C-mediated membrane processes. Nature. 317:549-551.
32. Parker, P.J., L. Coussens, N. Totty, L. Rhee, S. Young, E. Chen, S. Stabel, M.D. Waterfield, and A. Ullrich. 1986. The complete primary structure of protein kinase C: the major phorbol ester. Science. 233:853-859.
33. Lynch, J.J.L., T.J. Ferro, F.A. Blumenstock, A.M. Brockenauer, and A.B. Malik. 1990. Increased endothelial albumin permeability mediated by protein kinase C activation. J. Clin. Invest. 85:1991-1998.
34. Lum, H., P.J. Del Vecchio, A.S. Schneider, M.S. Goligorsky, and A.B. Malik. 1989. Calcium-dependence of the thrombin-induced increase in endothelial albumin permeability. J. Appl. Physiol. 66:1471-1476.
35. McEver, R.P. 1991. Properties of GMP-140, an inducible granule membrane protein of platelets and endothelium. J. Cell. Biochem. 45:156-161.
36. Zimmerman, G.A., S.M. Prescott, and T.M. McIntyre. 1992. Endothelial cell interactions with granulocytes: tethering and signaling molecules, Immunol. Today. 13:93-99.
37. Kutryk, M.J.B., and G.N. Pierce. 1991. Effects of low-density lipoprotein on calcium ion movements in cultured vascular smooth muscle cells. Coronary. Art. Dis. 2:1093-1101.
38. Barbir, M., F. Lazem, T. Bowker, P. Ludman, N. Banner, A. Mitchell, and M. Yacoub. 1997. Determinants of transplant-related coronary calcium detected by ultrafast computed tomography scanning. Am. J. Cardiol. 79:1606-1609.
39. Block, L.H., M. Knorr, E. Vogt, R. Locher, W. Vetter, P. Groscurth, B.Y. Qiao, D. Pometta, R. James, M. Regenass, and A. Pletscher. 1988. Low-density lipoprotein causes general cellular activation with increased phosphatidylinositol turnover and lipoprotein catabolism. Proc. Natl. Acad. Sci. USA. 85: 885-889.
40. Scott-Burden, T., T.A.J. Resink, A.W.A. Hahn, U. Baur, RJ. Box, and F.R. Buhler. 1989. Induction of growth-related metabolism in human vascular smooth muscle cells by low-density lipoprotein. J. Biol. Chem. 264:12582-12589.
41. Sachindis, A., R. Locher, T. Mengden, and W. Vetter. 1990. Low-density lipoprotein elevates intracellular calcium and pH in vascular smooth muscle cells and fibroblasts without mediation of the LDL receptor. Biochem. Biophys. Res. Commun. 167:353-359.
42. 3. Nature. 306:67-69.
43. Locher, R., A. Sachinidis, A. Steiner, and W. Vetter. 1990. Attenuation of the low-density-lipoprotein-activated phosphoinositide signaling system by calcium blockers in human lymphocytes. Clin. Sci. 78:509-514.
44. Avdonin, P.V., I.B. Cheglakov, E.M. Boogry, I.V. Svitina-Ulitina, A.V. Mazaev, and V.N. Tkachuk. 1987. Evidence for the receptor-operated calcium channels in human platelet plasma membrane. Thromb. Res. 46:29-37.
45. Ho, A.K., C.L. Chik, and D.C. Klein. 1988. Effects of protein kinase inhibitor (1-(5-isoquinolinesulfonyl)-2-methylpiperazin) (H-7) on protein kinase C activity and adrenergic-stimulation of cAMP and cGMP in rat pinealocytes. Biochem. Pharmacol. 37:1015-1020.
46. Bochkov, V.N., V.A. Tkachuk, F.R. Buhler, and T.J. Resink. 1992. Phosphoinositide and calcium signaling responses in smooth muscle cells: comparison between lipoproteins, Ang II and PDGF. Biochem. Biophys. Res. Commun. 188:1295-1304.
47. Bochkov, V.N., V.A. Tkachuk, Y.S. Kuzmenko, Y.L. Borisova, F.R. Buhler, and T.J. Resink. 1994. Characteristics of low and high density lipoprotein binding and lipoproiein-induced signaling in quiescent human vascular smooth muscle cells. Mol. Pharmacol. 45:262-270.
48. Murohara, M., R. Scalia, and A.M. Lefer. 1996. Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells. Possible involvement of protein kinase C activation and its inhibition by nitric oxide donors. Circ. Res. 78:780-789.
49. Sakai, A., N. Kume, H. Ochi, E. Nishi, H. Moriwaki, K. Tanoue, and T. Kita. 1995. P-selectin and VCAM-1 are focally expressed in hypercholesterolemic rabbits before intimai accumulation of macrophages and T lymphocytes. Circulation. 92(Suppl. 1):1558-1559. (Abstr.)
50. Gauthier, T.W., R. Scalia, T. Murohara, J.P. Guo, and A.M. Lefer. 1993. Nitric oxide protects against leukocyte-endothelial interaction of early hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 15:1652-1659.
51. Johnson, R.C., T.N. Mayadas, P.S. Frenette, R.E. Mebius, M. Subramaniam, A. Lacasce, R.O. Hynes, and D.D. Wagner. 1995. Blood cell dynamics in P-selectin-deficient mice. Blood. 86:1106-1114.
52. Cybalsky, M.L. and M.A. Gimbrone, Jr. 1991. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 251: 788-791.
53. Rosenfeld, M.E., T. Tsukada, A.M. Gown, and R. Ross. 1987. Fattystreak initiation in Watanabe heritable hyperlipidemic and comparably hypercholesterolemic fat-fed rabbits. Arteriosclerosis. 7:9-23.
54. Haller, H., D. Schaper, W. Ziegler, S. Philipp, M. Kuhlmann, A. Distler, and F.C. Luft. 1995. Low-density lipoprotein induces vascular adhesion molecule expression on human endothelial cells. Hypertension. 25:511-516.
55. Kume, N., M.I. Cybulsky, and M.A. Gimbrone. Jr. 1992. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J. Clin. Invest. 90:1138-1144.
56. Bochkov, V.N., V.A. Tkachuk, A.W.A. Hahn, J. Bernhardt, F.R. Buhler, and T.J. Resink. 1993. Concerted effects of lipoproteins and angiotensin II on vascular smooth muscle cells. Arterioscler. Thromb. 13:1261-1269.
57. Wood, K.M., M.D. Cadogan, A.L. Ramshaw, and D.V. Parums 1993. The distribution of adhesion molecules in human atherosclerosis. Histopathology. 22:437-444.
58. Taylor, P.M., M.L. Rose, and M.H. Yacoub. 1993. Coronary artery immunogenicity: a comparison between explanted recipient or donor hearts and transplanted hearts. Transplant. Immunol. 1:294-301.
59. Page, C., M.L. Rose, and M.H. Yacoub. 1992. Antigeneic heterogeneity of vascular endothelium. Am. J. Pathol. 141:673-683.
60. Hackman, A., Y. Abe, W. Insull, Jr., H. Pownail, L. Smith, K. Dunn, A.M. Gotto, Jr., and C.M. Ballantyne. 1996. Levels of soluble cell adhesion molecules in patients with dyslipidemia. Circulation. 93:1334-1338.