α Domain deletion converts sreptokinase into a fibrin-dependent plasminogen activator through mechanisms akin to staphylokinase and tissue plasminogen activator

Journal of Biological Chemistry

Volumn 279, Issue 24, 2004, Pages 24994-25001

  Sazonova, Irina Y ^a   Robinson, Brian R ^a   Gladysheva, Inna P ^a   Castellino, Francis J ^c   Reed, Guy L ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CONFORMATIONS; ENZYME INHIBITION; ENZYME KINETICS; SOLUTIONS; SUBSTRATES; TISSUE;

FIBRINS; PHYSIOLOGIC FLUIDS;

BIOCHEMISTRY;

ALPHA 2 ANTIPLASMIN; CHLORIDE ION; FIBRIN; PLASMINOGEN ACTIVATOR; STAPHYLOKINASE; STREPTOKINASE; TISSUE PLASMINOGEN ACTIVATOR;

ALPHA CHAIN; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; GENE DELETION; KRINGLE DOMAIN; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN;

ANTIPLASMIN; BINDING SITES; FIBRIN; HUMANS; METALLOENDOPEPTIDASES; PLASMIN; PLASMINOGEN; PROTEIN CONFORMATION; STREPTOKINASE; TISSUE PLASMINOGEN ACTIVATOR;

EID: 2942590331     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400253200     Document Type: Article

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