Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations

BMC Infectious Diseases

Volumn 2, Issue , 2002, Pages

  Duffy, Karen E ^a   Quail, Matthew R ^a   Nguyen, Tammy T ^a   Wittrock, Robert J ^a   Bartus, Joan O ^a   Halsey, Wendy M ^b   Leary, Jeffry J ^a   Bacon, Teresa H ^c   Sarisky, Robert T ^a  

^a Antimicrob/Host Def Ctr Excel   (United States)

^b GLAXOSMITHKLINE   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE BETA; DNA POLYMERASE; MUTAGENIC AGENT; PLASMID DNA; THYMIDINE KINASE; VIRUS PROTEIN; DNA DIRECTED DNA POLYMERASE; DNA POLYMERASE, SIMPLEXVIRUS; EXODEOXYRIBONUCLEASE; RECOMBINANT DNA; VIRUS DNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA STRUCTURE; ERROR; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; MUTAGENESIS; MUTATION RATE; MUTATOR GENE; NONHUMAN; SPONTANEOUS MUTATION; STATISTICAL SIGNIFICANCE; VIRUS GENOME; VIRUS ISOLATION; VIRUS RECOMBINANT; VIRUS REPLICATION; ANIMAL; BIOASSAY; BIOSYNTHESIS; CELL LINE; CERCOPITHECUS; CHEMISTRY; CONFORMATION; DNA REPLICATION; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MUTATION; PLASMID; VERO CELL;

ANIMALS; BIOLOGICAL ASSAY; CELL LINE; CERCOPITHECUS AETHIOPS; DNA POLYMERASE II; DNA REPLICATION; DNA, RECOMBINANT; DNA, VIRAL; DNA-DIRECTED DNA POLYMERASE; EXODEOXYRIBONUCLEASES; GENOME, VIRAL; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HUMANS; MUTAGENESIS; MUTATION; NUCLEIC ACID CONFORMATION; PLASMIDS; THYMIDINE KINASE; TRANSFECTION; VERO CELLS; VIRAL PROTEINS;

EID: 2942588695     PISSN: 14712334     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2334-2-7     Document Type: Article

References (28)

1. Aslani A, Simonsson S, Elias P: A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein. J. Biol. Chem. 2000, 275:5880-5887
2. Baer R, Bankier AT, Biggin MD, Deininger PL, Farrell PJ, Gibson TJ, Hatfull G, Hudson GS, Satchwell SC, Seguin C, Tuffnell PS, Barrell BG: DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature. 1984, 310:207-211
3. Bernad A, Blanco L, Lazaro JM, Martin G, Salas M: A conserved 3′- 5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases. Cell. 1989, 59:219-228
4. Boulet A, Simon M, Faye G, Bauer A, Burgers PMJ: Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III. EMBO J. 1989, 8:1849-1854
5. Challberg MD: A method for identifying the viral genes required for herpesvirus DNA replication. Proc. Natl. Acad. Sci. U. S. A. 1986, 83:9094-9098
6. Dasgupta UB, Summers WC: Ultraviolet reactivation of herpes simplex virus is mutagenic and inducible in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 1978, 75:2378-2381
7. Davison AJ, Scott JE: The complete DNA sequence of varicellazoster virus. J. Gen. Virol. 1986, 67:1759-1816
8. Earl PL, Jones EV, Moss B: Homology between DNA polymerases of poxviruses, herpesviruses, and adenoviruses: nucleotide sequence of the vaccinia virus DNA polymerase gene. Proc. Natl. Acad. Sci. USA 1986, 83:3659-3663
9. Gottlieb J, Marcy AI, Coen DM, Challberg MD: The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity. J. Virol. 1990, 64:5976-5987
10. Hall JD, Coen DM, Fisher BL, Weisslitz M, Randall S, Almy RE, Gelep PT, Schaffer PA: Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus. Virology 1984, 132:26-37
11. Hernandez TR, Lehman IR: Functional interaction between the herpes simplex-1 DNA polymerase and UL42 protein. J. Biol. Chem. 1990, 265:11227-11232
12. Hwang CC, Chen HH: An altered spectrum of herpes simplex virus mutations mediated by an antimutator DNA polymerase. Gene 1995, 152:191-193
13. Hwang YT, Liu BY, Hong CY, Shillitoe EJ, Hwang CC: Effects of exonuclease activity and nucleotide selectivity of the herpes simplex virus DNA polymerase on the fidelity of DNA replication in vivo. J. Virol. 1999, 73:5326-5332
14. Knopf CW: Properties of herpes simplex virus DNA polymerase and characterization of its associated exonuclease activity. Eur. J. Biochem. 1979, 98:231-244
15. Knopf CW, Weisshart K: Comparison of exonucleolytic activities of herpes simplex virus type-1 DNA polymerase and DNase. Eur. J. Biochem. 1990, 191:263-273
16. Marcy AI, Olivo PD, Challberg MD, Coen DM: Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells. Nucleic Acids Res. 1990, 18:1207-1215
17. Marcy AI, Yager DR, Coen DM: Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus. J. Virol. 1990, 64:2208-2216
18. Pizzagalli A, Valsasnini P, Plevani P, Lucchini G: DNA polymerase I gene of Saccharomyces cerevisiae: nucleotide sequence, mapping of a temperature-sensitive mutation and protein homology with other DNA polymerases. Proc. Natl. Acad. Sci. USA 1988, 85:3772-3776
19. Pyles RB, Thompson RL: Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells. J. Virol. 1994, 68:4514-4524
20. Roberts JD, Kunkel TA: Eukaryotic DNA replication fidelity,. In DNA replication in eukaryotic cells. (Edited by: ML DePamphilis) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 1996, 217-247
21. Sarisky RT, Nguyen TT, Duffy KE, Wittrock RJ, Leary JJ: Difference in incidence of spontaneous mutations distinct between herpes simplex virus types 1 and 2. Antimicrob. Agents Chemother. 2000, 44:1524-1529
22. Sarisky RT, Weber PC: Role of anisomorphic DNA conformations in the negative regulation of a herpes simplex virus type 1 promoter. Virology. 1994, 204:569-579
23. Shillitoe EJ, Zhang S, Wang G, Hwang CBC: Functions and proteins of herpes simplex virus type-1 that are involved in raising the mutation frequency of inefcted cells. Virus Res. 1993, 27:239-251
24. Singleton CK, Klysik J, Stirdivant SM, Wells RD: Left-handed ZDNA is induced by supercoiling in physiological ionic conditions. Nature. 1982, 299:312-316
25. Spicer EK, Rush J, Fung C, Reha-Krantz LJ, Karam JD, Konigsberg WH: Primary structure of T4 DNA polymerase. Evolutionary relatedness to eucaryotic and other procaryotic DNA polymerases. J. Biol. Chem. 1988, 263:7478-7486
26. Weisshart K, Kuo AA, Hwang CC, Kumura C, Coen DM: Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis. J. Biol. Chem 1994, 269:22788-22796
27. Wong SW, Wahl AF, Yuan PM, Arai N, Pearson BE, Arai KI, Korn D, Hunkapiller MW, Wang TSF: Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases. EMBO J. 1988, 7:37-47
28. Xiong X, Yang H, Westland CE, Zou R, Gibbs CS: In vitro evaluation of epatitis B virus polymerase mutations associated with famciclovir resistance. Hepatology. 2000, 31:219-224