Oxidation of protein by vaporized sanitizing agents

PDA Journal of Pharmaceutical Science and Technology

Volumn 58, Issue 3, 2004, Pages 121-129

  Wang, Wei ^a,b   Cui, Tian Yi ^a   Wang, Y John ^a   Martin Moe, Sheryl ^a  

^a Bayer Healthcare   (United States)

^b Bayer Healthcare   (United States)

Author keywords

Hydrogen peroxide; Lyophilization; Peracetic acid; Protein oxidation; Sanitization

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 MUTEIN; PERACETIC ACID; UNCLASSIFIED DRUG;

ARTICLE; DRUG MANUFACTURE; FREEZE DRYING; OXIDATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID STATE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISINFECTANTS; DRUG COMPOUNDING; DRUG CONTAMINATION; FREEZE DRYING; INTERLEUKIN-2; OXIDANTS; OXIDATION-REDUCTION; PHARMACEUTICAL SOLUTIONS; PROTEINS;

EID: 2942584913     PISSN: 10797440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. McDonnell, G.; Russell, A. D. Antiseptics and disinfectants: activity, action, and resistance. Clin. Microbiol. Rev. 1999, 12, 147-179.
2. Block, S. S. Peroxygen Compounds. In Disinfection, Sterilization, and Preservation, S.S. Block, Ed; Lee & Febiger: Philadelphia, PA, 1991; pp 167-181.
3. Kirsch, L. E.; Riggin, R. M.; Gearhart, D. A.; Lefeber, D. S.; Lytle, D. L. In-process protein degradation by exposure to trace amounts of sanitizing agents. J. Parenter. Sci. Technol. 1993, 47, 155-60.
4. Ha, E.; Wang, W.; Wang, Y. J. Peroxide formation in polysorbate 80 and protein stability. J. Pharm. Sci. 2002, 91, 2252-2264.
5. Sakagami, H.; Satoh, K.; Kadofuku, T.; Takeda, M. Methionine oxidation and apoptosis induction by ascorbate, gallate and hydrogen peroxide. Anticancer Res 1997, 17, 2565-2570.
6. Deutsch, J. C. Ascorbic acid oxidation by hydrogen peroxide. Anal. Biochem. 1998, 255, 1-7.
7. Nguyen, T. H.; Burnier, J.; Meng, W. The kinetics of relaxin oxidation by hydrogen peroxide. Pharm. Res. 1993, 10, 1563-1571.
8. Hayes, C. S.; Illades-Aguiar, B.; Casillas-Martinez, L.; Setlow, P. In vitro and in vivo oxidation of methionine residues in small, acid-soluble spore proteins from Bacillus species. J. Bacteriol. 1998, 180, 2694-2700.
9. Vogt, W. Oxidation of methionyl residues in proteins: tools, targets, and reversal. Free Radical Biol. Med. 1995, 18, 93-105.
10. Yao, Y.; Yin, D.; Jas, G.; Kuczer, K.; Williams, T.; Schoneich, C.; Squier, T. Oxidative modification of a carboxyl-terminal vicinal methionine in calmodulin by hydrogen peroxide inhibits calmodulin-dependent activation of the plasma membrane Ca-ATPase. Biochemistry 1996, 35, 2767-2787.
11. Hovorka, S.; Schoneich, C. Oxidative degradation of pharmaceuticals: theory, mechanisms and inhibition. J Pharm. Sci. 2001, 90, 253-269.
12. Kunitani, M.; Hirtzer, P.; Johnson, D.; Halenbeck, R.; Roosman, A.; Koths, K. Reverse-phase chromatography of interleukin-2 muteins. J. Chromatogr. 1986, 359, 391-402.
13. Sasaoki, K.; Hiroshima, T.; Kusumoto, S.; Nishi, K. Oxidation of methionine residues of recombinant human interleukin 2 in aqueous solution. Chem. Pharm. Bull. (Tokyo) 1989, 37, 2160-2164.
14. Van Patten, S. M.; Hanson, E.; Bernasconi, R.; Zhang, K.; Manavalan, P.; Cole, E. S.; McPherson, J. M.; Edmunds, T. Oxidation of methionine residues in antithrombin. Effects on biologic activity and heparin binding. J. Biol. Chem., 1999, 274, 10268-10276.
15. Escalup, L.; Crauste-Manciet, S.; Richard, L.; Brossard, D. Chemical sterilization with peracetic acid: permeation risks inside parenteral infusion fluid. PDA J. Pharm. Sci. Technol. 2001, 55, 24-32.