Ultrastructural changes in Langerhans cells in gingival overgrowth in cyclosporin A-treated renal transplant patients

Pathology

Volumn 36, Issue 3, 2004, Pages 242-246

  Mariani, Giustiniano ^a,c   Calastrini, Carla ^a   Aleotti, Arrigo ^a   Carnevale, Edvige ^a   Stabellini, Giordano ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c Dipartimento di Morfologia ed Embriologia   (Italy)

Author keywords

Cyclosporin A; Gingival epithelium; Gingival overgrowth; Langerhans cells

Indexed keywords

CYCLOSPORIN A; METHYLPREDNISOLONE; PROTEIN S 100;

ADULT; ARTICLE; CELL ULTRASTRUCTURE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTRON MICROSCOPY; EPITHELIUM; GINGIVA HYPERPLASIA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERKERATOSIS; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LANGERHANS CELL; MALE; MICROSCOPY; TISSUE SECTION;

EID: 2942577450     PISSN: 00313025     EISSN: None     Source Type: Journal    
DOI: 10.1080/00313020410001692585     Document Type: Article

References (34)

1. Stiller C, Laupacis A, Dupre J, et al. Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science 1984; 223: 1362-7.
2. French-Constant C, Wolman R, Feriant JD. Cyclosporine in Behcet's disease. (Letter.) Lancet 1983; ii: 454-5.
3. Isenberg D, Snaith M, Al-Klader A, et al. Cyclosporin relieves arthralgia, causes angioedema. New Engl J Med 1980; 303: 754.
4. Stiller CR, Keown PA, Sinclair NR, Ulan RA. Immune responses and pharmacokinetics in human renal allograft recipient treated with cyclosporine-A. In: Calne RY, White DS, editors. International Symposium on Cyclosporine-A. New York: Elsevier, 1981.
5. Klintman GBC, Iwatsuki S, Starzl TE. Cyclosporin A hepatotoxicity in 66 renal allograft recipients. Transplantation 1981; 32: 488-9.
6. Beaman M, Parvin S, Veitch PS, Walls J. Convulsions associated with cyclosporin A in renal transplant recipients. Br Med J 1985; 290: 139.
7. Starzl TE, Porter KA, Iwatsuki S, et al. Reversability of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet 1984; i: 583-7.
8. Rostock MH, Fry HR, Turner JE. Severe gingival overgrowth associated with cyclosporin therapy. J Periodontol 1986; 57: 294-9.
9. Langerhans P. Uber die Nerven der menschlichen Haut. Virchows Arch Abt B Pathol Anat 1868; 44: 325-37.
10. Waterhouse JP, Squire CA. The Langerhans cell in human gingival epithelium. Arch Oral Biol 1967; 12: 341-8.
11. Young WG. Epithelial kinetics affect Langerhans cell of mouse vaginal epithelium. Acta Anat 1985; 123: 131-6.
12. Al Yassin T, Toner PG. Langerhans cell in the human oesophagus. J Anat 1976; 122: 435-45.
13. Stingl G, Katz SI, Clement L, Green I, Shevach EM. Immunologic functions of Ia-bearing epidermal Langerhans cells. J Immunol 1978; 121: 2005-13.
14. Ferreira-Marques J. Systema sensitivum intraepidermicum: Die Langerhanszellen als Rezeptoren des hellen Schmerzes. Doloreceptors. Arch Klin Exp Dermatol 1951; 193: 191-250.
15. Billingham RS, Medawar PB. A study of the branched cells of the mammalian epidermis with special references to the fate of their division products. Phil Trans R Soc London (Biol) 1953; 237: 151-71.
16. Breathnach AS, Silvers WK, Smith J, Heyner S. Langerhans cells in mouse skin experimentally deprived of its neural crest component. J Invest Dermatol 1968; 50: 147-60.
17. Katz SI, Tamaki K, Sachs DH. Epidermal Langerhans cells are derived from cells originating in the bone marrow. Nature 1979; 282: 324-6.
18. Caux C, Vanbervliet B, Massacrier C, et al. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J Exp Med 1996; 184: 695-706.
19. Reid CD, Stackpoole A, Meager A, Tikerpae J. Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow. J Immunol 1992; 149: 2681-8.
20. Strobl H, Riedl E, Schneiecker C, et al. TGF-beta 1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors. J Immunol 1996; 157: 1499-507.
21. Stingl G, Katz SI, Green I, Shevach EM. The functional role of Langherans cells. J Invest Dermatol 1980; 74: 315-8.
22. Tay SK, Jenkins D. Langerhans cell population in early invasive squamous cell carcinoma of the uterine cervix. Aust NZ J Obstet Gynaecol 1989; 29: 38-40.
23. Penn I. Occurrence of malignancies in immunosuppressed organ transplant recipients. In: Abouna GM, Kumar MSA, White AG, editors. Organ Transplantation Proc 2nd East Soc Org Transplant. Dordrecht: Kluwer Academic Publisher, 1990; 475.
24. Bedani PL, Risichella IS, Strumia R, et al. Kaposi's sarcoma in renal transplant recipients: pathogenetic relation between the reduced density of Langerhans cells and cyclosporin A therapy. J Nephrol 1999; 12: 193-6.
25. Teunissen MB, De Jager MH, Kapsenberg ML, BOS JD. Inhibitory effect of cyclosporin A on antigen and alloantigen presenting capacity of human epidermal Langerhans cells. Br J Dermatol 1991; 125: 309-16.
26. Mollah ZU, Aiba S, Nakagawa S, et al. Macrophage colony-stimulating factor in cooperation with transforming growth factor-beta1 induces the differentiation of CD34+ hematopoietic progenitor cells into Langerhans cells under serum-free conditions without granulocyte-macrophage colony-stimulating factor. J Invest Dermatol 2003; 120: 256-65.
27. Demidem A, Taylor JR, Grammer SF, Streilein JW. Comparison of effects of transforming growth factor-beta and cyclosporin A on antigen-presenting cells of blood and epidermis. J Invest Dermatol 1991; 96: 401-7.
28. Mariani G, Calastrini C, Carinci F, Marzola R, Calura G. Ultrastructural features of Cyclosporine A-induced gingival hyperplasia. J Periodontol 1993; 64: 1092-7.
29. Mariani G, Calastrini C, Carinci F, et al. Ultrastructural and histochemical features of the ground substance in Cyclosporin A-induced gingival overgrowth. J Periodontol 1996; 67: 21-7.
30. Mariani G, Calastrini C, Bernabei P, Stabellini G. Aumento di volume gengivale indotto da ciclosporina. Accad Sci Ferrara, Atti 1996; 72/73: 247-67.
31. Hachisuga T, Fukuda K, Hayashi Y, Iwasaka T, Sugimori H. Immunohistochemical demonstration of histiocytes in normal ectocervical epithelial lesions of the uterine cervix. Gynecol Oncol 1989; 33: 273-8.
32. Hanau D, Fabre M, Schmitt DA, et al. Human epidermal Langerhans cells internalize by receptor-mediated endocytosis T6 (CD1 'NA1/34') surface antigen. Birbeck granules are involved in the intercellular traffic of the T6 antigen. J Invest Dermatol 1987; 89: 172-7.
33. Mc Dermott R, Ziylan U, Spehner D, et al. Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans Cells, which form where Langerin accumulates. Mol Biol Cell 2002; 13: 317-35.
34. Pisanty S, Rahamim E, Ben-Ezra D, Shoshan S. Prolonged systemic administration of Cyclosporin A affects gingival epitheliun. J Periodontol 1990; 61: 138-41.