Gene expression in intrahepatic tumors through DNA recombination by a replication-activated adenovirus vector

Cancer Gene Therapy

Volumn 11, Issue 6, 2004, Pages 450-456

  Huang, Xiao W ^a,c   Lieber, Andre ^b   Tang, Zhao Y ^c   Lawrence, Theodore S ^a   Moyer, Mary P ^d   Zhang, Ming ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c FUDAN UNIVERSITY   (China)

^d INCELL Corporation ^*  (United States)

Author keywords

Colorectal neoplasms; Liver neoplasms; Recombination; Replication activated adenovirus

Indexed keywords

ADENOVIRUS VECTOR; BETA GLUCURONIDASE; HYDROXYUREA; VIRUS DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOMA CELL; COLON CARCINOMA; COLON MUCOSA; CONTROLLED STUDY; DNA RECOMBINATION; DNA REPLICATION; FEMALE; GENE EXPRESSION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; INVERTED REPEAT; LIVER CELL CARCINOMA; LIVER METASTASIS; LIVER TUMOR; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TRANSGENE; TUMOR XENOGRAFT; VIRAL GENE THERAPY; VIRUS GENOME; VIRUS REPLICATION;

ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DNA; DNA, VIRAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEPATOCYTES; HUMANS; HYDROXYUREA; LIVER NEOPLASMS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

ADENOVIRIDAE; ANIMALIA; DNA VIRUSES; MUS MUSCULUS;

EID: 2942557213     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700719     Document Type: Article

References (21)

1. O'Connell MJ, Nagorney DM, Bernath AM, et al. Sequential intrahepatic fluorodeoxyuridine and systemic fluorouracil plus leucovorin for the treatment of metastatic colorectal cancer confined to the liver. J Clin Oncol. 1998;16:2528-2533.
2. Harmantas A, Rotstein LE, Langer B. Regional versus systemic chemotherapy in the treatment of colorectal carcinoma metastatic to the liver: is there a survival difference? Meta-analysis of the published literature. Cancer (Phila). 1996;78:1639.
3. Tang ZY. Hepatocellular carcinoma - cause, treatment and metastasis. World J Gastroenterol. 2001;7:445-454.
4. Grill J, Van Beusechem VW, Curiel DT, Gerritsen WR. Combined targeting of adenoviruses to integrins and epidermal growth factor receptors increases gene transfer into primary glioma cells and spheroids. Clin Caner Res. 2001;7:641-650.
5. Zhang M, Li SP, Nyati MK, et al. Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model. Cancer Res. 2003;63:658-663.
6. Nayti MK, Sreekumar SP, Li SP, et al. High and selective expression of yeast cytosine deaminase under a carcinoembryonic antigen promoter-enhancer. Cancer Res. 2002;62:2337-2342.
7. Bischoff JR, Kirn DH, Williams A, et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science. 1996;274:373-376.
8. Johnson L, Shen A, Boyle L, et al. Selective replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents. Cancer Cell. 2002;1:325-337.
9. Khuri FR, Nemunaitis J, Ganly I, et al. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat Med. 2000;6:879-885.
10. Nemunaitis J, Cunningham C, Buchanan A, et al. Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity. Gene Therapy. 2001;8:746-759.
11. Steinwaerder DS, Carlson CA, Lieber A. DNA replication of first-generation adenovirus vectors in tumor cells. Hum Gene Ther. 2000;11:1933-1948.
12. Steinwaerder DS, Carlson CA, Lieber A. Generation of adenovirus vectors devoid of all viral genes by recombination between inverted repeats. J Virol. 1999;73:9303-9313.
13. Steinwaerder DS, Carlson CA, Otto DL, et al. Tumor-specific gene expression in hepatic metastases by a replication-activated adenovirus vector. Nat Med. 2001;7:240-243.
14. Bernt KM, Steinwaerder DS, Ni SH, et al. Enzyme-activated prodrug therapy enhances tumor-specific replication of adenovirus vectors. Cancer Res. 2002;62:6089-6098.
15. Rothmann T, Hengstermann A, Whitaker NJ, et al. Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells. J Virol. 1998;72:9470-9478.
16. Hallenbeck PL, Chang YN, Hay C, et al. A novel tumor-specific replication-restricted adenoviral vector for gene therapy for hepatocellular carcinoma. Hum Gene Ther. 1999;10:1721-1733.
17. Li YH, Yu DC, Chen Y, et al. A hepatocellular carcinoma-specific adenovirus variant. CV890, eliminates distant human liver tumors in combination with doxorubicin. Caner Res. 2001;61:6428-6436.
18. Matsubara S, Wada Y, Gardner TA, et al. A conditional replication-competent adenoviral rector. Ad-OC-Ela, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis. Cancer Res. 2001;61:6012-6019.
19. Nelson JE, Kay MA. Persistence of recombinant adenovirus in vivo is not dependent on vector DNA replication. J Virol. 1997;71:8902-8907.
20. Rae RS, Mehta PP, Chang CC, et al. Neoplastic phenotype of gap-junctional intercellular communication-deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32. Mol Carcinogen. 1998;22:120-127.
21. Freytag SO, Khil M, Stricker H, et al. Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer. Cancer Res. 2002;62:4968-4976.