Allelic variation at the A218C tryptophan hydroxylase polymorphism influences agitation and aggression in Alzheimer's disease

Neuroscience Letters

Volumn 363, Issue 3, 2004, Pages 199-202

  Craig, David ^a   Hart, Dominic J ^a   Carson, Robin ^a   McIlroy, Stephen P ^a   Passmore, A Peter ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Aggression; Agitation; Alzheimer's disease; Dementia; Gene; Polymorphism; Tryptophan hydroxylase

Indexed keywords

TRYPTOPHAN HYDROXYLASE;

AGGRESSION; AGITATION; ALLELE; ALZHEIMER DISEASE; ANAMNESIS; DEMENTIA; DNA MODIFICATION; GENE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; IMMUNOLOGICAL TOLERANCE; INSTITUTIONAL CARE; PRIORITY JOURNAL; REVIEW; SEROTONINERGIC SYSTEM;

EID: 2942557083     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.02.054     Document Type: Article

References (32)

1. Bellivier F., Chaste P., Malafosse A. Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. Am. J. Med. Genet. 124B:2004;87-91
2. Burns A., Jacoby R., Levy R. Psychiatric phenomena in Alzheimer's disease. IV. Disorders of behaviour. Br. J. Psychiatry. 157:1990;86-94
3. 2 receptor binding in Lewy body dementia, Alzheimer's and Parkinson's diseases. J. Neurol. Sci. 106:1991;50-55
4. Cohen-Mansfield J., Billig N. Agitated behaviors in the elderly. I. A conceptual review. J. Am. Geriatr. Soc. 34:1986;711-721
5. Craig D., Hart D.J., McCool K., McIlroy S.P., Passmore A.P. Apolipoprotein E ε4 allele influences aggressive behaviour in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry. 2004;. in press
6. Cross A.J. Serotonin in Alzheimer-type dementia and other dementing illnesses. Ann. N. Y. Acad. Sci. 600:1990;405-417
7. Cusin C., Serretti A., Lattuada E., Lilli R., Lorenzi C., Mandelli L., Pisati E., Smeraldi E. Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders. J. Psychiatr. Res. 35:2001;217-223
8. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12:1975;189-198
9. Hirono N., Mega M.S., Dinov I.D., Mishkin F., Cummings J.L. Left frontotemporal hypoperfusion is associated with aggression in patients with dementia. Arch. Neurol. 57:2000;861-866
10. Holmes C. Contribution of genetics to the understanding of behavioural and psychological symptoms of dementia. Int. Psychogeriatr. 12:2000;83-88
11. Holtzer R., Tang M.X., Devanand D.P., Albert S.M., Wegesin D.J., Marder K., Bell K., Albert M., Brandt J., Stern Y. Psychopathological features in Alzheimer's disease: course and relationship with cognitive status. J. Am. Geriatr. Soc. 51:2003;953-960
12. Jonsson E.G., Goldman D., Spurlock G., Gustavsson J.P., Nielsen D.A., Linnoila M., Owen M.J., Sedvall G.C. Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Eur. Arch. Psychiatry Clin. Neurosci. 247:1997;297-302
13. Kaufer D.I., Cummings J.L., Christine D., Bray T., Castellon S., Masterman D., MacMillan A., Ketchel P., DeKosky S.T. Assessing the impact of neuropsychiatric symptoms in Alzheimer's disease: the Neuropsychiatric Inventory Caregiver Distress Scale. J. Am. Geriatr. Soc. 46:1998;210-215
14. Lawlor B. Serotonin and Alzheimer's disease. Psychiatr. Ann. 20:1990;567-570
15. Levy M.L., Cummings J.L., Fairbanks L.A., Bravi D., Calvani M., Carta A. Longitudinal assessment of symptoms of depression, agitation, and psychosis in 181 patients with Alzheimer's disease. Am. J. Psychiatry. 153:1996;1438-1443
16. Lopez O.L., Becker J.T., Sweet R.A., Klunk W., Kaufer D.I., Saxton J., Habeych M., DeKosky S.T. Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease. J. Neuropsychiatry Clin. Neurosci. 15:2003;346-353
17. Manuck S.B., Flory J.D., Ferrell R.E., Dent K.M., Mann J.J., Muldoon M.F. Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol. Psychiatry. 45:1999;603-614
18. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 34:1984;939-944
19. Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1988;1215
20. Mortimer J.A., Ebbitt B., Jun S.P., Finch M.D. Predictors of cognitive and functional progression in patients with probable Alzheimer's disease. Neurology. 42:1992;1689-1696
21. New A.S., Gelernter J., Yovell Y., Trestman R.L., Nielsen D.A., Silverman J., Mitropoulou V., Siever L.J. Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study. Am. J. Med. Genet. 81:1998;13-17
22. Nyth A.L., Gottfries C.G. The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disorders. Br. J. Psychiatry. 157:1990;894-901
23. Procter A.W., Francis P.T., Stratmann G.C., Bowen D.M. Serotonergic pathology is not widespread in Alzheimer patients without prominent aggressive symptoms. Neurochem. Res. 17:1992;917-922
24. Reinikainen K.J., Soininen H., Reikkinen P.J. Neurotransmitter changes in Alzheimer's dementia and agitation. J. Neurosci. Res. 27:1990;576-586
25. Reisberg B. Functional assessment staging (FAST). Psychopharmacol. Bull. 24:1988;653-659
26. Rujescu D., Giegling I., Bondy B., Gietl A., Zill P., Moller H.J. Association of anger-related traits with SNPs in the TPH gene. Mol. Psychiatry. 7:2002;1023-1029
27. Staner L., Uyanik G., Correa H., Tremeau F., Monreal J., Crocq M.A., Stefos G., Morris-Rosendahl D.J., Macher J.P. A dimensional impulsive-aggressive phenotype is associated with the A218C polymorphism of the tryptophan hydroxylase gene: a pilot study in well-characterized impulsive inpatients. Am. J. Med. Genet. 114:2002;553-557
28. Sweet R.A., Pollock B.G., Sukonick D.L., Mulsant B.H., Rosen J., Klunk W.E., Kastango K.B., DeKosky S.T., Ferrell R.E. The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease. Int. Psychogeriatr. 13:2001;401-409
29. Sweet R.A., Nimgaonkar V.L., Devlin B., Jeste D.V. Psychotic symptoms in Alzheimer disease: evidence for a distinct phenotype. Mol. Psychiatry. 8:2003;383-392
30. Tekin S., Mega M.S., Masterman D.M., Chow T., Garakian J., Vinters H.V., Cummings J.L. Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease. Ann. Neurol. 49:2001;355-361
31. Wang Y.C., Tsai S.J., Liu T.Y., Liu H.C., Hong C.J. No association between tryptophan hydroxylase gene polymorphism and Alzheimer's disease. Neuropsychobiology. 43:2001;1-4
32. Wilson R.S., Gilley D.W., Bennett D.A., Beckett L.A., Evans D.A. Hallucinations, delusions, and cognitive decline in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry. 69:2000;172-177