Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: Relationships to monoamine metabolite concentrations in CSF of healthy volunteers

European Archives of Psychiatry and Clinical Neuroscience

Volumn 247, Issue 6, 1997, Pages 297-302

  Jönsson, Erik G ^a   Goldman, David ^b   Spurlock, Gillian ^c   Gustavsson, J Petter ^a   Nielsen, David A ^b   Linnoila, Markku ^b   Owen, Michael J ^c   Sedvall, Göran C ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Catechol O methyltransferase gene; Cerebrospinal fluid; Monoamine metabolites (HVA, 5 HIAA, MHPG); Tryptophan hydroxylase gene

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 5 HYDROXYINDOLEACETIC ACID; CATECHOL METHYLTRANSFERASE; DOPAMINE; HOMOVANILLIC ACID; MONOAMINE; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

ADULT; ALLELE; ARTICLE; CEREBROSPINAL FLUID; DNA POLYMORPHISM; FEMALE; GENOTYPE; HUMAN; HUMAN EXPERIMENT; LUMBAR SPINAL CORD; MALE; METABOLITE; MONOAMINE METABOLISM; NORMAL HUMAN; PRIORITY JOURNAL; SEROTONIN METABOLISM; SEX DIFFERENCE; TURNOVER TIME;

EID: 0031434511     PISSN: 09401334     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02922258     Document Type: Article

References (35)

1. Abbar M, Courtet P, Amadéo S, Caer Y, Mallet J, Baldy-Moulinier M, Castelnau D, Malafosse A (1995) Suicidal behaviors and the tryptophan hydroxylase gene. Arch Gen Psychiatry 52: 846-849
2. Ågren H, Meffords I, Rudorfer M, Linnoila M, Potter W (1986) Interacting neurotransmitter systems. A non-experimental approach to the 5HIAA-HVA correlation in human CSF. J Psychiatr Res 20: 175-193
3. American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders (DSM-III-R), 3rd edn, revised. American Psychiatric Press, Washington, DC
4. Axelrod J, Tomchick R (1958) Enzymic O-methylation of epinephrine and other catechols. J Biol Chem 233: 702-705
5. Boudikova B, Szumlanski C, Maidak B, Weinshilboum R (1990) Human liver catechol-O-methyltransferase pharmacogenetics. Clin Pharmacol Ther 48: 381-389
6. Brahe C, Bannetta P, Meera KP, Arwert F, Serra A (1986) Assignment of the catechol-O-methyltransferase gene to human chromosome 22 in somatic cell hybrids. Hum Genet 74: 230-234
7. Cooper JR, Melcer I (1961) The enzymic oxidation of tryptophan to 5-hydroxytryptophan in the biosyntehsis of serotonin. J Pharm Exp Ther 132: 265-268
8. Craig SP, Boularand S, Darmon MC, Mallet J, Craig IW (1991) Localization of human tryptophan hydroxylase (TPH) to chromosome 11p15.3-p14 by in situ hybridization. Cytogenet Cell Genet 56: 157-159
9. Daniels JK, Williams NM, Williams J, Jones LA, Cardno AG, Murphy KC, Spurlock G, Riley B, Scambler P, Asherson P, McGuffin P, Owen MJ (1996) No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol-O-methyltransferase activity. Am J Psychiatry 153: 268-270
10. Dumas S, Darmon MC, Delort J, Mallet J (1989) Differential control of tryptophan hydroxylase expression in raphe and in pineal gland: evidence for a role of translational efficiency. J Neurosci Res 24: 537-547
11. Eriksson E, Alling C, Andersch B, Andersson K, Berggren U (1994) Cerebrospinal fluid levels of monoamine metabolites. A preliminary study of their relation to menstrual cycle phase, sex steroids, and pituitary hormones in healthy women and in women with premenstrual syndrome. Neuropsychopharmacology 11: 201-213
12. Eriksson E, Lisjö P, Sundblad C, Andersson K, Andersch B, Modigh K (1990) Effects of clomipramine on premenstrual syndrome. Acta Psychiatr Scand 81: 87
13. Geijer T, Neiman J, Rydberg U, Gyllander A, Jönsson E, Sedvall G, Valverius P, Terenius L (1994) Dopamine D2 receptor gene polymorphisms in Scandinavian chronic alcoholics. Eur Arch Psychiatry Clin Neurosci 244: 26-32
14. Grossman MH, Emanuel BS, Budarf ML (1992a) Chromsomal mapping of the human catechol-O-methyltransferase to 22q11.1-q11.2. Genomics 12: 822-825
15. Grossman MH, Littrell JB, Weinstein R, Szumlanski CL, Weinshilboum RM (1992b) Identification of the possible molecular basis for inherited differences in human catechol-O-methyltransferase. Soc Neurosci 18: 70
16. Guldberg HC, Marsden CA (1975) Catechol-O-methyltransferase: pharmacological aspects and physiological role. Pharmacol Rev 27: 135-206
17. Higley JD, Thompson WW, Champoux M, Goldman D, Hasert MF, Kraemer GW, Scanlan JM, Suomi SJ, Linnoila M (1993) Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in Rhesus monkeys (Macaca mulatta). Arch Gen Psychiatry 50: 615-623
18. Hsiao JK, Potter WZ, Ågren H, Owen RR, Pickar D (1993) Clinical investigation of monoamine neurotransmitter interactions. Psychopharmacology 112: S76-S84
19. Jönsson E, Sedvall G, Brené S, Gustavsson JP, Geijer T, Terenius L, Crocq M-A, Lannfelt L, Tylec A, Sokoloff P, Schwartz JC, Wiesel F-A (1996) Dopamine-related genes and their relationships to monoamine metabolites in CSF. Biol Psychiatry 40: 1032-1043
20. Ke F, Ramirez VD (1990) Binding of progesterone to nerve cell membranes of rat brain using progesterone conjugated to 1251-bovine serum albumin as a ligand. J Neurochem 54: 467-472
21. Klemetsdal B, Straume B, Giverhaug T, Aarbakke J (1994) Low catechol-O-methyltransferase activity in a Saami population. Eur J Clin Pharmacol 46: 231-235
22. Lachman HM, Papolos DF, Saito T, Yu Y-M, Szumlanski CL, Weinshilboum RM (1996) Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6: 243-250
23. Majewska MD (1992) Neurosteroids: endogenous bimodal modulators of the GABA A receptor: mechanism of action and physiological significance. Prog Neurobiol 38: 379-395
24. Nielsen DA, Dean M, Goldman D (1992) Genetic mapping of the human tryptophan hydroxylase gene on chromosome II, using an intronic conformational polymorphism. Am J Hum Genet 51: 1366-1371
25. Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M (1994) Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry 51: 34-38
26. Nielsen DA, Novoradovsky A, Goldman D (1995) SSCP primer design based on single-strand DNA structure predicted by a DNA folding program. Nucleic Acids Res 23: 2287-2291
27. Nielsen DA, Jenkins GL, Stefanisko KM, Jefferson KK, Goldman D (1997) Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7. Mol Brain Res 45: 145-148
28. Oxenstierna G, Edman G, Iselius L, Oreland L, Ross SB, Sedvall G (1986) Concentrations of monoamine metabolites in the cerebrospinal fluid of twins and unrelated individuals: a genetic study. J Psychiatr Res 20: 19-29
29. Pecins-Thompson M, Brown NA, Kohama SG, Bethea CL (1996) Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in Rhesus Macaques. J Neurosci 21: 7021-7029
30. Rickels K, Freedman EW, Sondheimer S, Albert J (1990) Fluoxetine in the treatment of premenstrual syndrome. Curr Ther Res 48: 161-166
31. Sedvall G, Fyrö B, Gullberg B, Nybäck H, Wiesel F-A, Wode-Helgodt B (1980) Relationships in healthy volunteers between concentrations of monoamine metabolites in cerebrospinal fluid and family history of psychiatric morbidity. Br J Psychiatry 136: 366-374
32. Sietnieks A, Andén N-E, Grabowska-Andén M (1983) Determination of serotonin in small brain structures by means of HPLC combined with electrochemical detection: the effect of ovarian steroids on serotonin turnover rate within several brain regions. Acta Pharmacol Toxicol 52: 398-400
33. Steiner M, Steinberg S, Stewart D, Carter D, Berger C, Reid R, Grover D, Streiner D (1995) Fluoxetine in the treatment of premenstrual dysphoria. N Engl J Med 332: 1529-1534
34. Swahn C-G, Sandgärde B, Wiesel F-A, Sedvall G (1976) Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic method. Psychopharmacology 48: 147-152
35. Winqvist R, Lundström K, Salminen M, Laatikainen M, Ulmanen I (1992) The human catechol-O-methyltransferase (COMT) gene maps to band q11.2 of chromosome 22 and shows a frequent RFLP with BgII. Cytogenet Cell Genet 59: 253-257