α1A-Adrenergic receptor polymorphism and vascular response

Clinical Pharmacology and Therapeutics

Volumn 75, Issue 6, 2004, Pages 539-545

  Sofowora, Gbenga G ^b   Dishy, Victor ^b   Landau, Ruth ^b   Xie, Hong Guang ^b   Prasad, Harish C ^b   Byrne, Daniel W ^b   Smiley, Richard M ^b   Kim, Richard B ^b   Wood, Alastair J J ^a   Stein, C Michael ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; ARGININE; CYSTEINE; PHENYLALANINE; PHENYLEPHRINE;

ADULT; ANALYTIC METHOD; ARTICLE; BLOOD VESSEL REACTIVITY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG SENSITIVITY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; GEOMETRY; HAND; HUMAN; HUMAN EXPERIMENT; HYPOTHESIS; IN VIVO STUDY; MALE; MEASUREMENT; NORMAL HUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; VASOCONSTRICTION; VEIN;

ADULT; ANALYSIS OF VARIANCE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MUSCLE, SMOOTH, VASCULAR; PHENYLEPHRINE; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, ALPHA-1; VASOCONSTRICTION;

EID: 2942555192     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clpt.2004.02.006     Document Type: Article

References (36)

1. Light K.C., Obrist P.A., Sherwood A., James S.A., Strogatz D.S. Effects of race and marginally elevated blood pressure on responses to stress. Hypertension. 10:1987;555-563
2. Alradi A.O., Carruthers S.G. Evaluation and application of the linear variable differential transformer technique for the assessment of human dorsal hand vein alpha-receptor activity. Clin Pharmacol Ther. 38:1985;495-502
3. Eichler H.G., Ford G.A., Blaschke T.F., Swislocki A., Hoffman B.B. Responsiveness of superficial hand veins to phenylephrine in essential hypertension. Alpha adrenergic blockade during prazosin therapy. J Clin Invest. 83:1989;108-112
4. Martin S.A., Alexieva S., Carruthers S.G. The influence of age on dorsal hand vein responsiveness to norepinephrine. Clin Pharmacol Ther. 40:1986;257-260
5. Dishy V, Sofowora G, Landau R, Xie H, Byrne D, Smiley R, et al. Balance of adrenergic vascular response is shifted towards enhanced vasodilation in premenopausal women [abstract]. Clin Pharmacol Ther 2002;71:P2
6. Stein C.M., Lang C.C., Singh I., He H.B., Wood A.J. Increased vascular adrenergic vasoconstriction and decreased vasodilation in blacks. Additive mechanisms leading to enhanced vascular reactivity. Hypertension. 36:2000;945-951
7. Luthra A., Borkowski K.R., Carruthers S.G. Genetic aspects of variability in superficial vein responsiveness to norepinephrine. Clin Pharmacol Ther. 49:1991;355-361
8. Gupta A., Carruthers S.G. Familial studies of heritability of alpha1-adrenergic receptor responsiveness in superficial veins. Clin Pharmacol Ther. 62:1997;322-326
9. Vargas H.M., Gorman A.J. Vascular alpha-1 adrenergic receptor subtypes in the regulation of arterial pressure. Life Sci. 57:1995;2291-2308
10. Hieble J.P., Bylund D.B., Clarke D.E., Eikenburg D.C., Langer S.Z., Lefkowitz R.J., et al. International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors consensus update. Pharmacol Rev. 47:1995;267-270
11. Mita M., Walsh M.P. alpha1-Adrenoceptor-mediated phosphorylation of myosin in rat-tail arterial smooth muscle. Biochem J. 327:(Pt 3):1997;669-674
12. Lachnit W.G., Tran A.M., Clarke D.E., Ford A.P. Pharmacological characterization of an alpha 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat. Br J Pharmacol. 120:1997;819-826
13. Rudner X.L., Berkowitz D.E., Booth J.V., Funk B.L., Cozart K.L., D'Amico E.B., et al. Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age. Circulation. 100:1999;2336-2343
14. Rokosh D.G., Simpson P.C. Knockout of the alpha 1A/C-adrenergic receptor subtype the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proc Natl Acad Sci U S A. 99:2002;9474-9479
15. Daly C.J., Deighan C., McGee A., Mennie D., Ali Z., McBride M., et al. A knockout approach indicates a minor vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse. Physiol Genomics. 9:2002;85-91
16. Shibata K., Hirasawa A., Moriyama N., Kawabe K., Ogawa S., Tsujimoto G. Alpha 1a-adrenoceptor polymorphism pharmacological characterization and association with benign prostatic hypertrophy. Br J Pharmacol. 118:1996;1403-1408
17. Michel M.C., Kenny B., Schwinn D.A. Classification of alpha 1-adrenoceptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 352:1995;1-10
18. Xie H.G., Kim R.B., Stein C.M., Gainer J.V., Brown N.J., Wood A.J. Alpha1A-adrenergic receptor polymorphism association with ethnicity but not essential hypertension. Pharmacogenetics. 9:1999;651-656
19. Stein C.M., Lang C.C., Xie H.G., Wood A.J. Hypertension in black people study of specific genotypes and phenotypes will provide a greater understanding of interindividual and interethnic variability in blood pressure regulation than studies based on race. Pharmacogenetics. 11:2001;95-110
20. Dishy V., Sofowora G., Harris P.A., Kandcer M., Zhan F., Wood A.J., et al. The effect of sildenafil on nitric oxide-mediated vasodilation in healthy men. Clin Pharmacol Ther. 70:2001;270-279
21. Dishy V., Sofowora G.G., Xie H.G., Kim R.B., Byrne D.W., Stein C.M., et al. The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med. 345:2001;1030-1035
22. Sofowora G., Dishy V., Xie H.G., Imamura H., Nishimi Y., Morales C.R., et al. In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism. Pharmacogenetics. 11:2001;809-814
23. Aellig W.H. A new technique for recording compliance of human hand veins. Br J Clin Pharmacol. 11:1981;237-243
24. Schindler C., Grossmann M., Dobrev D., Francke K., Ravens U., Kirch W. Reproducibility of dorsal hand vein responses to phenylephrine and prostaglandin F2 alpha using the dorsal hand vein compliance method. J Clin Pharmacol. 43:2003;228-236
25. Vincent J., Blaschke T.F., Hoffman B.B. Vascular reactivity to phenylephrine and angiotensin II comparison of direct venous and systemic vascular responses. Clin Pharmacol Ther. 51:1992;68-75
26. Feldman R.D. Defective venous beta-adrenergic response in borderline hypertensive subjects is corrected by a low sodium diet. J Clin Invest. 85:1990;647-652
27. Stein C.M., Nelson R., Deegan R., He H., Wood M., Wood A.J. Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension. J Clin Invest. 96:1995;579-585
28. Eichler H.G., Blaschke T.F., Hoffman B.B. Decreased responsiveness of superficial hand veins to phenylephrine in black normotensive males. J Cardiovasc Pharmacol. 16:1990;177-181
29. Kneale B.J., Chowienczyk P.J., Cockcroft J.R., Coltart D.J., Ritter J.M. Vasoconstrictor sensitivity to noradrenaline and NG-monomethyl-L-arginine in men and women. Clin Sci (Lond). 93:1997;513-518
30. Kneale B.J., Chowienczyk P.J., Brett S.E., Coltart D.J., Ritter J.M. Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature. J Am Coll Cardiol. 36:2000;1233-1238
31. Yan M., Sun J., Bird P.I., Liu D.L., Grigg M., Lim Y.L. Alpha1A- and alpha1B-adrenoceptors are the major subtypes in human saphenous vein. Life Sci. 68:2001;1191-1198
32. Vallance P., Collier J., Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 2:1989;997-1000
33. Miyamoto Y., Saito Y., Kajiyama N., Yoshimura M., Shimasaki Y., Nakayama M., et al. Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension. 32:1998;3-8
34. Philip I., Plantefeve G., Vuillaumier-Barrot S., Vicaut E., LeMarie C., Henrion D., et al. G894T polymorphism in the endothelial nitric oxide synthase gene is associated with an enhanced vascular responsiveness to phenylephrine. Circulation. 99:1999;3096-3098
35. Buscher R., Herrmann V., Ring K.M., Kailasam M.T., O'Connor D.T., Parmer R.J., et al. Variability in phenylephrine response and essential hypertension a search for human alpha(1B)-adrenergic receptor polymorphisms. J Pharmacol Exp Ther. 291:1999;793-798
36. Graham R.M., Perez D.M., Hwa J., Piascik M.T. alpha 1-Adrenergic receptor subtypes. Molecular structure, function, and signaling. Circ Res. 78:1996;737-749