Development of inhaled steroids based upon prodrugs with prolonged intraluminal retention time

Inhaled Steroids in Asthma: Optimizing Effects in the Airways

Volumn , Issue , 2016, Pages 565-576

  Axelsson, Bengt ^a   Bäckman, Per ^a   Strandberg, Per ^a   Brattsand, Ralph ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 2942544907     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.3109/9780203908532-25     Document Type: Chapter

References (15)

1. Kaiser H, Edsbäcker S. Dose-proportional pharmacokinetics (PK) of inhaled budesonide (Pulmicort Turbuhaler) in patients with mild asthma. Am J Respir Crit Care Med 1994; 149:A467.
2. Ryrfeldt Å, Andersson P, Edsbäcker S, Tönnesson M, Davies D, Pauwels R. Pharmacokinetics and metabolism of budesonide, a selective glucocorticosteroid. Eur J Respir Dis 1982; 63(suppl 122):86-95.
3. Miller-Larsson A, Mattsson H, Hjertberg E, Dahlbäck M, Tunek A, Brattsand R. Reversible fatty acid conjugation of budesonide. Novel mechanism for prolonged retention of topically applied steroid in airway tissue. Drug Metabol Dispos 1998; 26:623-630.
4. Thorsson L, Thunissen FBJM, Korn S, Carlshaf A, Edsbäcker S, Wouters EFM. Formation of fatty acid conjugates of budesonide in human lung tissue in vivo. Am J Respir Crit Care Med 1998; 157:A404.
5. Brattsand R. What factors determine anti-inflammatory activity and selectivity of inhaled steroids? Eur Respir Rev 1997; 7 (50):356-361.
6. Thalen A, Axelsson B, Andersson P, Brattsand R, Nylander B, Wickström L-I. 6a-Fluoro-and 6a, 9a-difluoro-11b, 21-dihydroxy-16-a, 17a-propylene-dioxypregn-4-ene-3, 20-dione: Synthesis and evaluation of activity and kinetics of their C-22 epimers. Steroids 1998; 63:37-43.
7. Brattsand R, Axelsson B. Basis for airway selectivity of inhaled glucocorticiods. In:Schleimer RP, Busse WW, O’Byrne PM, eds. Inhaled Glucocorticoids in Asthma. New York: Marcel Dekker; 1997:351-379.
8. Brattsand R, Axelsson B. New inhaled glucocorticosteroids. In: Barnes PJ, ed. New Drugs for Asthma. London: IBC Techn Serv, 1992:192-2078.
9. Brattsand R, Johansson U, Källström L. Sephadex-induced inflammation in the rat. Model description and protective action by drugs (abstr). Int J Microcirc Clin Exp 1986; 5:263.
10. Willén H, Carlén B, Brattsand R. Sephadex-induced inflammation in the rat lung: II Light and electron microscopic studies (abstr.) Int J Microcirc Clin Exp 1986; 5: 263.
11. Bjermer L, Sandström T, Särnstrand B, Brattsand R. Sephadex-induced granulomatous alveolitis in rat-effect on antigen manipulation. Am J Industr Med 1994; 25:73-78.
12. Abraham WM. Sheep models of allergic bronchoconstriction. Allergy Allergic Dis 1997; 1-2:1045-1055
13. Abraham WM, Lanes S, Stevenson JS, Yerger LD. Effect of an inhaled glucocorticosteroid (budesonide) on post-antigen induced increases in airway responsiveness. Bull Eur Physiopathol Respir 1986; 22(4): 387-392.
14. Schreier H, Gonzales-Rothi RJ, Stecenco AA. Pulmonary delivery of liposomes. J Controlled Release 1993; 24:209-223.
15. Wright JR, Clements JA. Metabolism and turnover of lung surfactant. Am Rev Respir Dis 1987; 135:426-444.