6α-fluoro- and 6α,9α-difluoro-11β,21-dihydroxy- 16α,17α- propylmethylene-dioxypregn-4-ene-3,20-dione: Synthesis and evaluation of activity and kinetics of their C-22 epimers

Steroids

Volumn 63, Issue 1, 1998, Pages 37-43

  Thalén, B Arne ^a   Axelsson, Bengt I ^a   Andersson, Paul H ^a   Brattsand, Ralph L ^a   Nylander, Benkt ^a   Wickström, Lars Inge ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

17 acetals; Biotransformation; Glucocorticosteroid 16 ; Receptor affinities; Synthesis

Indexed keywords

6ALPHA FLUORO 11BETA,21 DIHYDROXY 16ALPHA,17ALPHA PROPYLMETHYLENEDIOXYPREGN 4 ENE 3,20 DIONE; 6ALPHA,9ALPHA DIFLUORO 11BETA,21 DIHYDROXY 16ALPHA,17ALPHA PROPYLMETHYLENEDIOXYPREGN 4 ENE 3,20 DIONE; BUDESONIDE; DEXAMETHASONE; GLUCOCORTICOID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; BIOTRANSFORMATION; BRONCHUS MUCOSA; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; INFLAMMATORY DISEASE; INTESTINE MUCOSA; MALE; NONHUMAN; RAT; THYMUS;

ANIMALIA; BRONCHUS;

EID: 0031963106     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(97)00107-4     Document Type: Article

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