QSAR of adenosine receptor antagonists. Part 3: Exploring physicochemical requirements for selective binding of 1,2,4-triazolo[5,1-i]purine derivatives with human adenosine A3 receptor subtype

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 14, 2004, Pages 3705-3709

  Roy, Kunal ^a   Leonard, J Thomas ^a   Sengupta, Chandana ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

1,2,4 Triazolo 5,1 i purine derivatives; Adenosine A3 receptor; AM1 calculations; QSAR; Selectivity

Indexed keywords

ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR ANTAGONIST; PENTOBARBITAL; PROPANE; PURINE DERIVATIVE; RECEPTOR SUBTYPE;

ARTICLE; ATOM; BINDING AFFINITY; CALCULATION; CONJUGATION; DRUG BINDING; DRUG SELECTIVITY; ELECTRICITY; ENERGY; FRAGMENTATION REACTION; GEOMETRY; MATHEMATICAL COMPUTING; MOLECULAR CLONING; MOLECULE; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL SIGNIFICANCE;

BINDING, COMPETITIVE; HUMANS; MAST CELLS; PURINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTOR, ADENOSINE A3; REGRESSION ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 2942530853     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.05.007     Document Type: Article

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