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Successful strategy for rapid isolation of nonpeptidic antagonists at the neuropeptide y (NPY Y1) from readily available starting products.
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A modular approach for the synthesis of multidentate molecules based on the condensation of easily accessible N-alkylheteroarylamines and pyrazole or triazole building blocks.
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This synthetic strategy allows incorporation of four sources of diversity starting from amine scaffolds, acrylates and acylating reagents.
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Gardiner JM, Crewe PD, Smith GE, Veal KT: Novel isomenthone-derived 1, 3-diol ligands identified through parallel synthesis and screening catalysis an asymmetric aldol reaction. Chem Commun 2003:618-619.
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Optimizing preparative LC/MS configurations and methods for parallel synthesis purification
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