Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: The synthesis and biological activities of RPR127963 an orally bioavailable inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 18, 2003, Pages 3097-3100

  He, Wei ^a,b   Myers, Michael R ^a,c   Hanney, Barbara ^a,c   Spada, Alfred P ^a,c   Bilder, Glenda ^a,c   Galzcinski, Helen ^a,c   Amin, Dilip ^a,c   Needle, Saul ^a,c   Page, Ken ^a,c   Jayyosi, Zaid ^a,c   Perrone, Mark H ^a,c  

^a SANOFI   (France)

^b Drug Discovery   (United States)

^c Department of Medicinal Chemistry ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR RECEPTOR INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; QUINOXALINE DERIVATIVE; RPR 101511 A; RPR 127963; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; RESTENOSIS; STRUCTURE ACTIVITY RELATION; SWINE;

SUS SCROFA;

EID: 12444339774     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00655-3     Document Type: Conference Paper

References (13)

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2. (b) Myers, M. R. The SCI-Fine Chemicals sponsored conference Protein Tyrosin Kinases, Good Targets for Drugs?, London, May 22, 2001.
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11. Bilder G.E., Wentz T., Leadley R., Amin D., Byan L., O'Conner B., Needle S., Galczenski H., Bostwick J., Kasiewski C., Myers M.R., Spada A.P., Merkel L., Ly C., Persons P., Page K., Perrone M., Dunwiddie C. Circulation. 99:1999;3292.
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13. The synthesis of the corresponding amino alcohols will be published later.