Use of highly reactive, versatile and air-stable palladium-phosphinous acid complex [(t-Bu)2P(OH)]2PdCl2 (POPd) as a catalyst for the optimized Suzuki-Miyaura cross-coupling of less reactive heteroaryl chlorides and arylboronic acids

Tetrahedron Letters

Volumn 45, Issue 27, 2004, Pages 5283-5286

  Khanapure, Subhash P ^a   Garvey, David S ^a  

^a NitroMed Inc   (United States)

Author keywords

3 Chloropyridines; Arylboronic acids; Cyclooxygenase; POPd; Suzuki Miyamura

Indexed keywords

BORONIC ACID DERIVATIVE; CHLORIDE; PALLADIUM COMPLEX; PHOSPHORUS ACID DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE;

ARTICLE; CATALYSIS; COMPLEX FORMATION; QUANTUM YIELD; SUBSTITUTION REACTION; SUZUKI REACTION; SYNTHESIS;

LATEOLABRAX JAPONICUS;

EID: 2942518465     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.05.010     Document Type: Article

References (18)

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13. Khanapure, S. P.; Augustyniak, M.; Garvey, D. S.; Gordon, L. G.; Martino, A.; Murty, M.; Schwalb, D. J.; Shumway, M.; Trocha, M.; Young, D. V.; Zemtseva, I. S.; Janero, D. R. J. Med. Chem. (submitted for publication)
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17. POPd catalysts are commercially available from CombiPhos Catalysts, Inc., Princeton, NJ 08542
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