Challenges of structural genomics: Bioinformatics

Drug Discovery Today: BIOSILICO

Volumn 1, Issue 1, 2003, Pages 36-41

  Godzik, Adam ^a,b   Canaves, Jaume ^a   Grzechnik, Slawomir ^a   Jaroszewski, Lukasz ^a   Morse, Andrew ^a   Ouyang, Je ^a   Wang, Xianhong ^a   West, Bill ^a   Wooley, John ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN;

BACTERIAL GENOME; DNA MICROARRAY; HEALTH CARE PLANNING; HUMAN; MEDICAL INFORMATICS; NONHUMAN; OPEN READING FRAME; REVIEW; ROBOTICS; STRUCTURAL GENOMICS; THERMOTOGA MARITIMA; THREE DIMENSIONAL IMAGING; X RAY CRYSTALLOGRAPHY;

EID: 2942511144     PISSN: 17418364     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1478-5382(03)02259-5     Document Type: Review

References (19)

1. Brown, P.O. and Botstein, D. (1999) Exploring the new world of the genome with DNA microarrays. Nat. Genet. 21(1 Suppl). 33-37
2. Ito, T. et al. (2001) A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc. Natl. Acad. Sci. U. S. A. 98, 4569-4574
3. Ho, Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature, 415, 180-183
4. Rowland, R.S. (2002) Using X-ray crystallography in drug discovery. Curr. Opin. Drug Discov. Devel. 5, 613-619
5. Hendrickson, W.A. (2000) Synchrotron crystallography. Trends Biochem. Sci. 25, 637-643
6. Wider, G. and Wuthrich, K. (1999) NMR spectroscopy of large molecules and multimolecular assemblies in solution. Curr. Opin. Struct. Biol. 9, 594-601
7. Berman, H.M. et al. (2000) The Protein Data Bank. Nucleic Acids Res. 28, 235-242
8. Rost, B. (1998) Marrying structure and genomics. Structure 6, 259-263
9. Burley, S.K. et al. (1999) Structural genomics: beyond the human genome project. Nat. Genet. 23, 151-157
10. Schmid, M. (2002) Structural proteomics: the potential of high-throughput structure determination. Trends Microbiol. 10(Suppl), S27
11. Buchanan, S.G. (2002) Structural genomics: bridging functional genomics and structure-based drug design. Curr. Opin. Drug Discov. Devel. 5, 367-381
12. Sali, A. (1998) 100,000 protein structures for the biologist. Nat. Struct. Biol. 5, 1029-1032
13. Service, R.F. (2002) Structural genomics. Tapping DNA for structures produces a trickle. Science 298, 948-950
14. Lesley, S.A. et al. (2002) Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc. Natl. Acad. Sci. U. S. A. 99, 11664-11669
15. Chance, M.R., et al. (2002) Structural genomics: a pipeline for providing structures for the biologist. Protein Sci. 11, 723-738
16. Brenner, S.E. (2001) A tour of structural genomics. Nat. Rev. Genet. 2, 801-809
17. Kuhn, P. et al. (2002) Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins 49, 142-145
18. Pawlowski, K. et al. (2001) Fold predictions for bacterial genomes. J. Struct. Biol. 134, 219-231
19. Thornton, J.M. et al. (2000) From structure to function: approaches and limitations. Nat. Struct. Biol. 7 Suppl, 991-994