Carvedilol blocks cardiac KATP and KG but not I K1 channels by acting at the bundle-crossing regions

European Journal of Pharmacology

Volumn 529, Issue 1-3, 2006, Pages 47-54

  Kikuta, Jun Ichi ^a   Ishii, Masaru ^a   Kishimoto, Kentaro ^a   Kurachi, Yoshihisa ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adrenoceptor blocking agent; Bundle crossing; Carvedilol; Inward rectifier K + channel

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; AMINO ACID DERIVATIVE; CARVEDILOL; CYSTEINE; GUANINE NUCLEOTIDE BINDING PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SENSITIVITY; HUMAN; HUMAN CELL; MALE; MEMBRANE CHANNEL; MOLECULAR INTERACTION; MOLECULAR MODEL; MUTATION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SIMULATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CARBAZOLES; CELL LINE; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUSCLE CELLS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROPANOLAMINES; RABBITS;

EID: 29344474002     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.10.059     Document Type: Article

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