Effect of low molecular λ-carrageenan from Chondrus ocellatus on antitumor H-22 activity of 5-Fu

Pharmacological Research

Volumn 53, Issue 2, 2006, Pages 129-134

  Zhou, Gefei ^a,b   Sheng, Wenxu ^c   Yao, Wenhong ^d   Wang, Changhai ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b YANTAI UNIVERSITY   (China)

^c Pathological Section of Laiyang Healthy School   (China)

^d QINGDAO AGRICULTURAL UNIVERSITY   (China)

Author keywords

5 Fu; Antitumor; Immunocompetence; Low molecular carrageenan

Indexed keywords

CARRAGEENAN; FLUOROURACIL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER TRANSPLANTATION; CHONDRUS; CHONDRUS OCELLATUS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DEGRADATION; DRUG ISOLATION; HISTOPATHOLOGY; IMMUNOCOMPETENCE; LYMPHOCYTE PROLIFERATION; MICROWAVE RADIATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; SAMPLE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CARRAGEENAN; CELL LINE, TUMOR; CELL PROLIFERATION; CHONDRUS; DRUG SYNERGISM; FLUOROURACIL; LYMPHOCYTES; MICE; MICE, INBRED ICR; MOLECULAR WEIGHT; NEOPLASM TRANSPLANTATION; ORGAN SIZE; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 29344436017     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2005.09.009     Document Type: Article

References (20)

1. K.C. Güven, Y. özsoy, and O.N. Ulutin Anticoagulant, fibrinolytic and antiaggregant activity of carrageenans and alginic acid Bot Mar 34 1991 429 432
2. G. Zhou, Y.P. Sun, H. Xin, Y. Zhang, Z. Li, and Z. Xu In vivo anti-tumor and immunomodulation activities of different molecular weight lambda-carrageenans from chondrus ocellatus Pharmacol Res 50 1 2004 47 53
3. G. Zhou, H. Xin, W. Sheng, Y. Sun, Z. Li, and Z. Xu In vivo growth-inhibition of S180 tumor by mixture of 5-Fu and low molecular λ-carrageenans from Chondrus ocellatus Pharmacol Res 51 2 2005 153 157
4. G. Frantz Polysaccharides in pharmacy: current applications and future concepts Planta Med 55 1989 493 497
5. R. DePhilippis, and M. Vincenzini Exocellular polysaccharides from cyanobacteria and their possible applications FEMS Microbiol Rev 22 1998 151 175
6. Q. Zhang, N. Li, G. Zhou, X. Lu, Z. Xu, and Z. Li In vivo antioxidant activity of polysaccharide fraction from Porphyra haitanesis (Rhodephyta) in aging mice Pharmacol Res 48 2 2003 151 155
7. Zuhong X, Zhien L, Xingjun Z, Yucai G. Application of Fucodian polysaccharides sulfate as a drug for treating chronic renal failure. CN 98 1 20283. 1995;7.
8. J. Fengwu, and Z. Yushun The dictionary of Chinese oceanic medicine 1993 Ocean Press p. 160
9. C. Parish Pharmacological properties of a marine natural product Biophys Acta 936 1987 55 59
10. D.J. Schaeffer, and V.S. Krylov Anti-HIV Activity of extracts and compounds from algae and cyanobacteria Carbohydr Polymers 41 2000 185 190
11. R.L. Tellam, and C.R. Parish The effect of sulfated polysaccharides on the free intracellular calcium ion concentration of lymphocytes Biochem Biophys Acta 930 1987 55 64
12. W. Anderson, and J.G.C. Duncan The anticoagulant activity of carrageenan J Pharm Pharmacol 17 1965 647 654
13. R. Shi, Z. Xu, and Z. Li The antitumor activity of degraded polysaccharide from Chondrus Ocellatus Chinese J Oceanol Limnol 31 6 2000 653 656
14. Z. Weiyun, and J.F. Zhou The influence of laver polysaccharide on the growth of immune cells and tumor cells Res Life Sci 6 2002 167 170
15. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 1983 55 63
16. 13C high resolution NMR spectroscopy of carrageenans: application on research and industry Trend Food Sci Technol 13 2002 73 92
17. Ishizaka S, Hasuma T, Otani S, Morisawa S. Lymphocyte activation by purified carrageenan. J Immunol 1980;125:2232-5.
18. N. Takiguchi, N. Saito, M. Nunomura, K. Kouda, K. Oda, and N. Furuyama Use of 5-FU plus hyperbaric oxygen for treating malignant tumors: evaluation of antitumor effect and measurement of 5-FU in individual organs Cancer Chemother Pharmacol 47 2001 11 14
19. J.Z. Wang, H. Tsumura, K. Shimura, and H. Ito Antitumor activity of polysaccharide from a Chinese medicinal herb, Acanthopanax giraldii Harms Cancer Lett 65 1 1992 79 84
20. Zhou G. Chemical composition of Chondrus Ocellatus and the antitumor activities of lambda-carrageenan. PhD thesis, Qingdao, China: Institute of Oceanology, Chinese Academy of Sciences; 2004: 69-87.