Natural killer and CD8 T cells dominate the response by human peripheral blood mononuclear cells to inactivated Francisella tularensis live vaccine strain

Human Immunology

Volumn 66, Issue 10, 2005, Pages 1039-1049

  Gosselin, Edmund J ^a   Gosselin, Diane R ^a   Lotz, Steven A ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

CD8 T cell; Francisella tularensis; Human; Immune response; NK cell

Indexed keywords

INACTIVATED VACCINE; LIVE VACCINE;

ARTICLE; CELL POPULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DATA ANALYSIS; FRANCISELLA TULARENSIS; HUMAN; HUMAN CELL; MEDICAL RESEARCH; NATURAL KILLER T CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; VIRULENCE;

ANTI-BACTERIAL AGENTS; ANTIBODIES, BACTERIAL; BACTERIAL VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; FORMALDEHYDE; FRANCISELLA TULARENSIS; HUMANS; IMMUNOMAGNETIC SEPARATION; INTERFERON TYPE II; INTERLEUKIN-2; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTOR-ALPHA; ULTRAVIOLET RAYS; VACCINES, ATTENUATED;

EID: 29344434090     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2005.08.240     Document Type: Article

References (20)

1. P.C. Oyston, A. Sjostedt, R.W. Titball Tularaemia bioterrorism defense renews interest in Francisella tularensis Nat Rev Microbiol 2 2004 967
2. A. Tarnvik Nature of protective immunity to Francisella tularensis Rev Infect Dis 11 1989 440
3. D.S. Burke Immunization against tularemia analysis of the effectiveness of live Francisella tularensis vaccine in prevention of laboratory-acquired tularemia J Infect Dis 135 1977 55
4. M. Ericsson, G. Sandstrom, A. Sjostedt, A. Tarnvik Persistence of cell-mediated immunity and decline of humoral immunity to the intracellular bacterium Francisella tularensis 25 years after natural infection J Infect Dis 170 1994 110
5. H.M. Surcel, H. Syrjala, R. Karttunen, S. Tapaninaho, E. Herva Development of Francisella tularensis antigen responses measured as T-lymphocyte proliferation and cytokine production (tumor necrosis factor alpha, gamma interferon, and interleukin-2 and -4) during human tularemia Infect Immun 59 1991 1948
6. D.M. Waag, A. Galloway, G. Sandstrom, C.R. Bolt, M.J. England, G.O. Nelson, J.C. Williams Cell-mediated and humoral immune responses induced by scarification vaccination of human volunteers with a new lot of the live vaccine strain of Francisella tularensis J Clin Microbiol 30 1992 2256
7. D.M. Waag, G. Sandstrom, M.J. England, J.C. Williams Immunogenicity of a new lot of Francisella tularensis live vaccine strain in human volunteers FEMS Immunol Med Microbiol 13 1996 205
8. R. Karttunen, H.M. Surcel, G. Andersson, H.P. Ekre, E. Herva Francisella tularensis-induced in vitro gamma interferon, tumor necrosis factor alpha, and interleukin 2 responses appear within 2 weeks of tularemia vaccination in human beings J Clin Microbiol 29 1991 753
9. A. Tarnvik, S.E. Holm Stimulation of subpopulations of human lymphocytes by a vaccine strain of Francisella tularensis Infect Immun 20 1978 698
10. + T cells does not affect the magnitude of protective immunity to an intracellular pathogen, Francisella tularensis strain LVS J Immunol 157 1996 5042
11. A. Ferrante, Y.H. Thong A rapid one-step procedure for purification of mononuclear and polymorphonuclear leukocytes from human blood using a modification of the Hypaque-Ficoll technique J Immunol Methods 24 1978 389
12. + T cells induced by dendritic cells following antigen uptake in the presence of specific antibody Vet Immunol Immunopathol 49 1996 321
13. H.S. Warren, B.F. Kinnear Quantitative analysis of the effect of CD16 ligation on human NK cell proliferation J Immunol 162 1999 735
14. S. Esin, G. Batoni, M. Pardini, F. Favilli, D. Bottai, G. Maisetta, W. Florio, R. Vanacore, H. Wigzell, M. Campa Functional characterization of human natural killer cells responding to Mycobacterium bovis bacille Calmette-Guérin Immunology 112 2004 143
15. A. Chalifour, P. Jeannin, J.F. Gauchat, A. Blaecke, M. Malissard, T. N'Guyen, N. Thieblemont, Y. Delneste Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production Blood 104 2004 1778
16. S. Sivori, M. Falco, M. Della Chiesa, S. Carlomagno, M. Vitale, L. Moretta, A. Moretta CpG and double-stranded RNA trigger human NK cells by Toll-like receptors induction of cytokine release and cytotoxicity against tumors and dendritic cells Proc Natl Acad Sci U S A 101 2004 10116
17. I. Becker, N. Salaiza, M. Aguirre, J. Delgado, N. Carrillo-Carrasco, L.G. Kobeh, A. Ruiz, R. Cervantes, A.P. Torres, N. Cabrera, A. Gonzalez, C. Maldonado, A. Isibasi Leishmania lipophosphoglycan (LPG) activates NK cells through Toll-like receptor-2 Mol Biochem Parasitol 130 2003 65
18. J.A. Hamerman, K. Ogasawara, L.L. Lanier NK cells in innate immunity Curr Opin Immunol 17 2005 29
19. H. Muller-Alouf, C. Carnoy, M. Simonet, J.E. Alouf Superantigen bacterial toxins state of the art Toxicon 39 2001 1691
20. C.E. Bolger, C.A. Forestal, J.K. Italo, J.L. Benach, M.B. Furie The live vaccine strain of Francisella tularensis replicates in human and murine macrophages but induces only the human cells to secrete proinflammatory cytokines J Leukoc Biol 77 2005 893