Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist

Pharmacology Biochemistry and Behavior

Volumn 82, Issue 3, 2005, Pages 417-426

  Contó, Marcos Brandão ^a   De Carvalho, José Gilberto Barbosa ^a   Benedito, Marco Antonio Campana ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anxiety; Clonic convulsions; Depression; DMCM; Elevated plus maze; Epilepsy; Forced swimming test; Open field; Picrotoxin; Rats

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR INVERSE STIMULATING AGENT; CONVULSANT AGENT; PICROTOXIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BRAIN REGION; CLONIC SEIZURE; CONTROLLED STUDY; DEPRESSION; DRUG SENSITIVITY; FEAR; FORCED SWIMMING TEST; MALE; MAZE TEST; MOTOR DYSFUNCTION; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; RAT; REARING; STATISTICAL SIGNIFICANCE;

ANIMALS; BEHAVIOR, ANIMAL; BENZODIAZEPINES; CARBOLINES; CONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; PICROTOXIN; RATS; RATS, WISTAR; SEIZURES;

ANIMALIA; RATTUS NORVEGICUS;

EID: 29244491982     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2005.09.012     Document Type: Article

References (53)

1. R.E. Adamec, and H.D. Morgan The effect of kindling of different nuclei in the left and right amygdala on anxiety in the rat Physiol Behav 55 1994 1 12
2. M. Angrini, J.C. Leslie, and R.A. Shephard Effects of propranolol, buspirone, pCPA, reserpine, and chlordiazepoxide on open-field behavior Pharmacol Biochem Behav 59 1998 387 397
3. A. Armario, and A.G.O. Martí Forced swimming test in rats:effects od desipramine administration and the period of exposure to the tes on struggling behavior, swimming, immobility and defecation rate Eur J Pharmacol 158 1988 207 212
4. C. Belzung, and G. Griebel Measuring normal and pathological anxiety-like behaviour in mice: a review Behav Brain Res 125 2001 141 149
5. H.F. Bradford, J.C. Belinda, M. Hillmann, D. Seidelmann, M. Klewer, and G.H. Jones Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat Psychopharmacology 121 1995 118 126
6. C. Braestrup, R. Schmiechen, G. Neef, M. Nielsen, and E.N. Petersen Interaction of convulsive ligands with benzodiazepine receptors Science 216 1982 1241 1243
7. 3H]DMCM, a convulsive benzodiazepine ligand, to rat brain membranes: preliminary studies J Neurochem 41 1983 454 465
8. G. Cannizzaro, A. Flugy, C. Cannizzaro, M. Gagliano, and M. Sabatino Effects of desipramine and alprazolam in the forced swim test in rats after long-lasting termination of chronic exposure to picrotoxin and pentylenetetrazol Eur Neuropsychopharmacol 3 1993 477 484
9. G. Chapouthier, and P. Venault A pharmacological link between epilepsy and anxiety? TIPS 22 2001 491 493
10. M. Chebib, and G.A.R. Johnston The 'ABC' of GABA receptors: a brief review Clin Exp Pharmacol Physiol 26 1999 937 940
11. Y. Clément, D. Bondoux, J.M. Launay, and G. Chapouthier Convulsive effects of a benzodiazepine receptor inverse agonist: are they related to anxiogenic processes? J Physiol (Paris) 91 1997 21 29
12. J.C. Cole, M. Hillmann, D. Seidelmann, M. Klewer, and G.H. Jones Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat Psychopharmacology 121 1995 118 126
13. W.E. Crusio Genetic dissection of mouse exploratory behaviour Behav Brain Res 125 2001 127 132
14. G. De Sarro, A. Chimirri, M. Zappala, P. Guisti, M. Lipartiti, and A. De Sarro Azirinol [1,2-d][1,4]benzodiazepine derivates and related 1,4-benzodiazepines as anticonvulsant agents in DBA/2 mice Gen Pharmacol 27 1996 1155 1162
15. D.S. Eidman, M.A.C. Benedito, and J.R. Leite Daily changes in pentylenetetrazol-induced convulsions and open-field behavior in rats Physiol Behav 47 1990 853 856
16. B receptor alterations as indicators of physiological and pharmacological function Biochem Pharmacol 68 2004 1541 1548
17. K. Gale Progression and generalization of seizure discharge: anatomical and neurochemical substrates Epilepsia 29 1988 S15 S34
18. R.E. Grahn, B.A. Kalman, F.X. Brennan, L.R. Watkins, and S.F. Maier The elevated plus-maze is not sensitive to the effect of stressor controllability in rats Pharmacol Biochem Behav 52 1995 565 570
19. P. Greengard The neurobiology of slow synaptic transmission Science 294 2001 1024 1030
20. D.K. Hannesson, J. Howland, M. Pollock, P. Mohapel, A.E. Wallace, and M.E. Corcoran Dorsal hippocampal kindling produces a selective and enduring disruption of hippocampally mediated behavior J Neurosci 21 2001 4443 4450
21. J. Hawkins Inbreeding considerations in a REM sleep model for rat swimming activity Experientia 42 1986 134 136
22. V. Helfer, C. Deransart, C. Marescaux, and A. Depaulis Amygdala kindling in the rat: anxiogenic-like consequences Neuroscience 73 1996 971 978
23. Y.J. Ho, J. Eichendorff, and R.K.W. Schwarting Individual response profiles of male Wistar rats in animal models for anxiety and depression Behav Brain Res 136 2002 1 12
24. A receptor pharmacology Pharmacol Ther 69 1996 173 198
25. M. Kabbaj, and H. Akil Individual differences in novelty-seeking behavior in rats: a c-fos study Neuroscience 106 2001 535 545
26. L.E. Kalynchuk, J.P.J. Pinel, D. Treit, and T.E. Kippin Changes in emotional behavior produced by long-term amygdale kindling in rats Biol Psychiatry 41 1997 438 451
27. L.E. Kalynchuk, J.P.J. Pinel, and D. Treit Long-term kindling and interictal emotionality in rats: effect of stimulation site Brain Res 779 1998 149 157
28. P. Kwan, G.J. Sills, and M.J. Brodie The mechanisms of action of commonly used antiepileptic drug Pharmacol Ther 90 2001 21 34
29. A. Lahmame, and A. Armario Differential responsiveness of inbred strains of rats to antidepressants in the forced swimming test: are Wistar Kyoto rats an animal model of subsensitivity to antidepressants? Psychopharmacology 123 1996 191 198
30. J.T. Litchfield, and F. Wilcoxon A simplified method of evaluating dose-effect experiments J Pharmacol Exp Ther 96 1949 99 113
31. A receptor subunits TIPS 12 1991 49 51
32. L. Marsh, and V. Rao Psychiatric complications in patients with epilepsy: a review Epilepsy Res 49 2002 11 33
33. J. Marti, and A. Armario Effects of diazepam and desipramine in the forced swimming test: influence of previous experience with the situation Eur J Pharmacol 236 1993 295 299
34. A receptors Brain Res Rev 29 1999 196 217
35. M. Nazar, M. Siemiatkowski, A. Czlonkowska, H. Sienkiewiz-Jarosz, and A. Plasnik The role of the hippocampus and 5-HT/GABA interaction in the central effects of benzodiazepine receptor ligands J Neural Transm 106 1999 369 381
36. S.A. Nieminen, J. Sirviö, K. Teittinen, A. Pitkanen, M.M. Airaksinen, and P. Riekkinen Amygdala kindling increased fear-response, but did not impair spatial memory in rats Physiol Behav 51 1992 845 849
37. R.G. Paredes, and A. ?gmo GABA and behavior: the role of receptors subtypes Neurosci Biobehav Rev 16 1992 145 170
38. C.R. Pawlak, and R.K.W. Schwarting Object preference and nicotine consumption in rats with high vs. low rearing activity in a novel open field Pharmacol Biochem Behav 73 2002 679 687
39. S. Pellow Can drug effects on anxiety and convulsions be separated Neurosci Biobehav Rev 9 1985 55 73
40. S. Pellow, P. Chopin, S.E. File, and M. Briley Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat J Neurosci Methods 14 1985 149 167
41. R.D. Porsolt, G. Anton, N. Blavet, and M. Jalfre Behavioural despair in rats: a new model sensitive to antidepressant treatments Eur J Pharmacol 47 1978 379 391
42. L. Prut, and C. Belzung The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review Eur J Pharmacol 463 2003 3 33
43. R.J. Racine Modification of seizure activity by electrical stimulation: Motor seizure Electroenceph Clin Neurophysiol 32 1972 281 294
44. U. Rudolph, F. Crestani, D. Benke, I. Brunig, J.A. Benson, and J.M. Fritschy Benzodiazepine actions mediated by specific gamma-aminobutyric acid A receptor subtypes Nature 401 1999 796 800
45. P.R. Sanberg, and K. Ossenkopp Kindling rates in Wistar rats: an analysis of individual differences Physiol Behav 20 1978 205 207
46. A. Sattin, A.E. Pekary, and R.L. Lloyd TRH gene products are implicated in the antidepressant mechanisms of seizures Ann N Y Acad Sci 739 1994 135 153
47. M.M. Schweri, J.V. Martin, W.B. Mendelson, J.E. Barrett, S.M. Paul, and P. Skolnick Pharmacokinetic and pharmacodynamic factors contributing to the convulsant action of beta-carboline-3-carboxylic acid esters Life Sci 33 1983 1505 1510
48. T.W. Seale, K.A. Abla, T.H. Roderick, OM. Rennert, and J.M. Carney Different genes specify hyporesponsiveness to seizures induced by caffeine and the benzodiazepine inverse agonist, DMCM Pharmacol Biochem Behav 27 1987 451 456
49. I. Shiah, and L.N. Yatham GABA function in mood disorders: an update and critical review Life Sci 63 1998 1289 1303
50. G. Sierra-Paredes, and G. Sierra-Marcuño Effects of NMDA antagonists on seizure thresholds induced by intrahippocampal microdialysis of picrotoxin in freely moving rats Neurosci Lett 218 1996 62 66
51. G. Sierra-Paredes, and G. Sierra-Marcuño Microperfusion of picrotoxin in the hippocampus of chronic freely moving rats through microdialysis probes: a new method of induce partial and secondary generalized seizures J Neurosci Methods 67 1996 113 120
52. A/benzodiazepine receptors in rats with genetic absence-epilepsy Epilepsy Res 47 2001 43 53
53. A.J. Wintink, N.A. Young, A.C. Davis, A. Gregus, and L.E. Kalynchuk Kindling-induced emotional behavior in male and female rats Behav Neurosci 117 2003 632 640