Chromosome copy number and leukemia-Lessons from Down's syndrome

Hematology

Volumn 10, Issue SUPPL. 1, 2005, Pages 164-166

  Izraeli, Shai ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR RUNX1;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ANEUPLOIDY; CELL PROLIFERATION; CHROMOSOME NUMBER; DISEASE ASSOCIATION; DOWN SYNDROME; GENE AMPLIFICATION; GENE MUTATION; GERM LINE; HUMAN; LEUKEMIA; MEGAKARYOCYTE; MYELOPOIESIS; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; RISK FACTOR; SHORT SURVEY; TRISOMY 21;

ANEUPLOIDY; CELL LINEAGE; DOWN SYNDROME; GATA1 TRANSCRIPTION FACTOR; HUMANS; LEUKEMIA, MEGAKARYOCYTIC, ACUTE;

EID: 29244488537     PISSN: 10245332     EISSN: 16078454     Source Type: Journal    
DOI: 10.1080/10245330512331390276     Document Type: Short Survey

References (6)

1. Hasle H. Pattern of malignant disorders in individuals with Down's syndrome. Lancet Oncol 2001;2:429-436.
2. Wechsler J, Greene M, McDevitt MA, et al. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet 2002;32:148-152.
3. Rainis L, Bercovich D, Strehl S, et al. Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21. Blood 2003;102:981-986.
4. Antonarakis SE, Lyle R, Dermitzakis ET, Reymond A, Deutsch S. Chromosome 21 and down syndrome: from genomics to pathophysiology. Nat Rev Genet 2004;5:725-738.
5. Hitzler JK, Zipursky A. Origins of leukaemia in children with Down syndrome. Nat Rev Cancer 2005;5:11-20.
6. Li Z, Godinho FJ, Klusmann JH, Garriga-Canut M, Yu C, Orkin SH. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet 2005;37:613-616.