Pressor responses to ephedrine are mediated by a direct mechanism in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 316, Issue 1, 2006, Pages 95-105

  Liles, John T ^a   Dabisch, Paul A ^a   Hude, Keith E ^a   Pradhan, Leena ^a   Varner, Kurt J ^b   Porter, Johnny R ^b   Hicks, Alissa R ^b   Corll, Conni ^b   Baber, Syed R ^a   Kadowitz, Philip J ^a,c  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SL83 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; AMPHETAMINE; CATECHOLAMINE; EPHEDRINE; METIROSINE; NORADRENALIN TRANSPORTER; RECEPTOR BLOCKING AGENT; RESERPINE; TYRAMINE;

ADRENERGIC NERVE; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTERY RESISTANCE; ARTICLE; ATTENUATION; BLOOD FLOW; DOSE RESPONSE; HINDLIMB; LUNG ARTERY PRESSURE; MALE; NERVE ENDING; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; TACHYPHYLAXIS; VASOCONSTRICTION;

AMPHETAMINE; ANESTHESIA; ANIMALS; BLOOD PRESSURE; CATECHOLAMINES; CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCAINE; EPHEDRINE; HINDLIMB; MALE; NOREPINEPHRINE; PHENYLEPHRINE; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC; REGIONAL BLOOD FLOW; RESERPINE;

EID: 29244452081     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.090035     Document Type: Article

References (39)

1. Abdullah AH, Tye A, and Patil PN (1968) Steric aspects of adrenergic drugs. X. Tachyphylaxis to the ephedrine isomers in the isolated rabbit heart. Arch Int Pharmacodyn Ther 174:454-468.
2. Abrahams TP, Faust ML, and Varner KJ (1996) The depletion of monoamines blocks the sympathoinhibitory response to cocaine. J Auton Nerv Syst 58:170-176.
3. Ashar BH, Miller RG, Getz KJ, and Pichard CP (2003) A critical evaluation of Internet marketing of products that contain ephedra. Mayo Clin Proc 78:944-946.
4. Baber SR, Hyman AL, and Kadowitz PJ (2003) Role of COX-1 and -2 in prostanoid generation and modulation of angiotensin II responses. Am J Physiol 285:H2399-H2410.
5. Bao JX, Wang B, and Yang ZC (1990) Effects of ephedrine on postsynaptic alpha-adrenoceptors and presynaptic beta-adrenoceptors in isolated guinea pig portal veins. Zhongguo Yao Li Xue Bao 11:130-133.
6. Burn JH and Rand MJ (1958) The action of sympathomimetic amines in animals treated with reserpine. J Physiol (Lond) 144:314-336.
7. Cairolli VJ, Reilly JF, and Roberts J (1962) Effect of reserpine pretreatment on the response of isolated papillary muscle to ephedrine. Br Pharm Chemother 18:588-594.
8. Cockings JG and Brown M (1997) Ephedrine abuse causing acute myocardial infarction. Med J Aust 167:199-200.
9. de Moraes S and Carvalho FV (1968) Reciprocal pressor effects between amphetamine and some sympathomimetic amines. Pharmacology 1:129-134.
10. Food and Drug Administration, HHS (2004) Final rule declaring dietary supplements containing ephedrine alkaloids adulterated because they present an unreasonable risk. Final rule. Fed Regist 69:6787-6854.
11. Fischer JF and Cho AK (1979) Chemical release of dopamine from striatal homogenates: evidence for an exchange diffusion model. J Pharmacol Exp Ther 208:203-209.
12. Fleckenstein A and Burn JH (1953) The effect of denervation on the action of sympathomimetic amines on the nictitating membrane. Br J Pharmacol 8:69-78.
13. Foxford RJ, Sahlas DJ, and Wingfield KA (2003) Vasospasm-induced stroke in a varsity athlete secondary to ephedrine ingestion. Clin J Sport Med 13:183-185.
14. Furukawa T and Morishita H (1975) Modifications of responses to adrenergic drugs in arterial strip by treatment in vivo with ephedrine and reserpine. Jpn J Pharmacol 25:441-451.
15. Grzesk G, Polak G, Grabczewska Z, and Kubica J (2004) Myocardial infarction with normal coronary arteriogram: the role of ephedrine-like alkaloids. Med Sci Monit 10:CS15-CS21.
16. Haller CA and Benowitz NL (2000) Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 343:1833-1838.
17. Kawasuji T, Koike K, and Saito H (1996) Chronotropic effects of optical isomers of ephedrine and methylephedrine in the isolated rat right atria and in vitro assessment of direct and indirect actions on beta 1-adrenoceptors. Biol Pharm Bull 19:1423-1428.
18. rd (2004) Banned, but not forgotten: a case of ephedrine-induced psychosis. Prim Care Companion J Clin Psychiatry 6:136-137.
19. Kobayashi S, Endou M, Sakuraya F, Matsuda N, Zhang XH, Azuma M, Echigo N, Kemmotsu O, Hattori Y, and Gando S (2003) The sympathomimetic actions of l-ephedrine and d-pseudoephedrine: direct receptor activation or norepinephrine release? Anesth Analg 97:1239-1245.
20. Lambrecht JE, Hamilton W, and Rabinovich A (2002) A review of herb-drug interactions: documented and theoretical. US Pharm 25:8.
21. Martin WR, Sloan JW, Sapira JD, and Jasinski DR (1971) Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine and methylphenidate in man. Clin Pharmacol Ther 12:245-258.
22. McMahon LR and Cunningham KA (2003) Discriminative stimulus effects of (-)-ephedrine in rats: analysis with catecholamine transporter and receptor ligands. Drug Alcohol Depend 70:255-264.
23. Miller DK, McMahon LR, Green TA, Nation JR, and Wellman PJ (1998) Repeated administration of ephedrine induces behavioral sensitization in rats. Psychopharmacology 140:52-56.
24. Miller SC and Waite C (2003) Ephedrine-type alkaloid-containing dietary supplements and substance dependence. Psychosomatics 44:508-511.
25. Morishita H and Furukawa T (1975) The vascular changes after ephedrine tachyphylaxis. J Pharm Pharmacol 27:574-579.
26. Purdy RE, Ashbrook DW, Hurlbut DE, Reidy JP, Stratford RE, and Watanabe MY (1981) Effects of reserpinization, surgical denervation and in vitro chemical denervation with 6-hydroxydopamine on the contractile response of isolated rabbit ear artery to propranolol. Blood Vessels 18:153-160.
27. Rothman RB, Vu N, Partilla JS, Roth BL, Hufeisen SJ, Compton-Toth BA, Birkes J, Young R, and Glennon RA (2003) In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates. J Pharmacol Exp Ther 307:138-145.
28. Sabol KE and Seiden LS (1998) Reserpine attenuates D-amphetamine and MDMA-induced transmitter release in vivo: a consideration of dose, core temperature and dopamine synthesis. Brain Res 806:69-78.
29. Schindler CW, Zheng JW, Tella SR, and Goldberg SR (1992) Pharmacological mechanisms in the cardiovascular effects of methamphetamine in conscious squirrel monkeys. Pharmacol Biochem Behav 42:791-796.
30. Schwartz AB, Boyle W, Janzen J, and Jones RT (1988) Acute effects of cocaine on catecholamines and cardiac electrophysiology in the conscious dog. Can J Cardiol 4:188-192.
31. Simpson LL (1980) Evidence that there are subcellular pools of norepinephrine and that there is flux of norepinephrine between these pools. J Pharmacol Exp Ther 214:410-416.
32. Sulzer D and Rayport S (1990) Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action. Neuron 5:797-808.
33. Takasaki K, Urabe M, and Yamamoto R (1972) Tachyphylaxis of indirectly acting sympathomimetic amines. III. Influence of acutely and chronically administered reserpine. Kurume Med J 19:153-168.
34. Tye A, Baldesberger R, LaPidus JB, and Patil PN (1967) Steric aspects of adrenergic drugs. VI. Beta adrenergic effects of ephedrine isomers. J Pharmacol Exp Ther 157:356-362.
35. Uehara T, Sumiyoshi T, Itoh H, and Kurachi M (2004) Inhibition of dopamine synthesis with alpha-methyl-p-tyrosine abolishes the enhancement of methamphetamine-induced extracellular dopamine levels in the amygdala of rats with excitotoxic lesions of the entorhinal cortex. Neurosci Lett 356:21-24.
36. Vansal SS and Feller DR (1999) Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes. Biochem Pharmacol 58:807-810.
37. Waldeck B and Widmark E (1985) The interaction of ephedrine with beta-adrenoceptors in tracheal, cardiac and skeletal muscles. Clin Exp Pharmacol Physiol 12:439-442.
38. Young R and Glennon RA (1998) Discriminative stimulus properties of (-)ephedrine. Pharmacol Biochem Behav 60:771-775.
39. Zahn KA, Li RL, and Purssell RA (1999) Cardiovascular toxicity after ingestion of "herbal ecstacy". J Emerg Med 17:289-291.