Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 11, 1998, Pages 2127-2131

  Guan, Jian ^a   Zhu, Xiao Kang ^a   Tachibana, Yoko ^a   Bastow, Kenneth F ^a   Brossi, Arnold ^a   Hamel, Ernest ^b   Lee, Kuo Hsiung ^a  

^a Sch P   (United States)

^b Lab of Drug Discov R and D   (United States)

Author keywords

Colchiceinamide; Colchicine; Demethylation; Topoisomerase; Tubulin

Indexed keywords

COLCHICEINE; COLCHICINE; DEMETHYLCOLCHICEINAMIDE DERIVATIVE; GYRASE INHIBITOR; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CHEMICAL MODIFICATION; CYTOTOXICITY; DEMETHYLATION; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL SURVIVAL; COLCHICINE; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; FEMALE; HUMANS; INDICATORS AND REAGENTS; KIDNEY NEOPLASMS; KINETICS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0031795450     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00165-5     Document Type: Article

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