Warfarin induction at 5 mg daily is safe with a low risk of anticoagulant overdose: Results of an audit of patients with deep vein thrombosis commencing warfarin

Internal Medicine Journal

Volumn 35, Issue 12, 2005, Pages 717-720

  Harper, Paul ^a   Monahan, K ^b   Baker, B ^b  

^a AUCKLAND CITY HOSPITAL   (New Zealand)

^b PALMERSTON NORTH HOSPITAL   (New Zealand)

Author keywords

Anticoagulation; Deep vein thrombosis; Venous thrombosis; Warfarin

Indexed keywords

WARFARIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BLEEDING; BLOOD EXAMINATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL AUDIT; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 29244434531     PISSN: 14440903     EISSN: 14455994     Source Type: Journal    
DOI: 10.1111/j.1445-5994.2005.00973.x     Document Type: Article

References (9)

1. Fennerty A, Dolben J, Thomas P. Flexible induction dose regimen for warfarin and prediction of maintenance dose. BMJ 1984; 288: 1268-70.
2. Harrison L, Johnston M, Massicotte MP, Crowther M, Moffat K, Hirsh J. Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy. Ann Intern Med 1997; 126: 133-6.
3. Crowther MA, Ginsberg JB, Kearon C, Harrison L, Johnson J, Massicotte MP et al. A randomized trial comparing 5-mg and 10-mg warfarin loading doses. Arch Intern Med 1999; 159: 46-8.
4. Roberts GW, Helboe T, Nielsen CB, Callus AS, Jensen I, Cosh DG et al. Assessment of an age-adjusted warfarin initiation protocol. Ann Pharmacother 2003; 37: 799-803.
5. Kovacs MJ, Rodger M, Anderson DR, Morrow B, Keils J, Kovacs J et al. Comparison of 10-mg and 5-mg warfarin initiation nomograms together with low-molecular-weight heparin for outpatient treatment of acute venous thromboembolism. A randomized, double-blind, controlled trial. Ann Intern Med 2003; 138: 714-19.
6. Rose P. Audit of anticoagulation therapy. J Clin Pathol 1996; 49: 5-9.
7. Malik A, Taylor A. Can warfarin trials be reproduced in real life? Adherence to warfarin guidelines for intensity of anticoagulation in a University based warfarin clinic. South Med J 2000; 93: 58-61.
8. Samsa GP, Matchar DB, Goldstein LB, Bonito AJ, Lux LJ, Witter DM et al. Quality of anticoagulation management among patients with atrial fibrillation: results of a review of medical records from 2 communities. Arch Intern Med 2000; 160: 967-73.
9. Fennerty A, Campbell AI. Anticoagulants in venous thromboembolism. BMJ 1988; 297: 1285-8.