Pulmonary arterial hypertension in mixed connective tissue disease: Successful treatment with Iloprost

Rheumatology International

Volumn 26, Issue 3, 2006, Pages 264-269

  Végh, Judit ^a   Soós, Györgyike ^a   Csipõ, István ^a   Demeter, Nóra ^a   Ben, Thomas ^a   Dezsõ, Balázs ^a   Zeher, Margit ^a   Dévényi, Katalin ^b   Gaál, János ^c   Szegedi, Gyula ^a   Bodolay, Edit ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c Kenezy Korhaz Rendelointezet   (Hungary)

Author keywords

Echocardiography; Mixed connective tissue disease; Prostacyclin; Pulmonary arterial hypertension

Indexed keywords

CORTICOSTEROID; CYCLOPHOSPHAMIDE; ILOPROST; LOW MOLECULAR WEIGHT HEPARIN; PROSTACYCLIN DERIVATIVE;

ADULT; ARTICLE; CASE REPORT; DOPPLER ECHOCARDIOGRAPHY; DOSE RESPONSE; FEMALE; HEART ARREST; HEART CATHETERIZATION; HEMOPTYSIS; HUMAN; LUNG ARTERY PRESSURE; LUNG BIOPSY; LUNG EMBOLISM; MIXED CONNECTIVE TISSUE DISEASE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; TACHYPNEA; VASCULAR DISEASE;

AUTOANTIBODIES; BIOPSY; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; HUMANS; HYPERTENSION, PULMONARY; ILOPROST; MIDDLE AGED; MIXED CONNECTIVE TISSUE DISEASE; VASODILATOR AGENTS;

EID: 29244433052     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-005-0616-8     Document Type: Article

References (36)

1. Sharp GC, Irvin WS, Tan EM, Gould RG, Holman HR (1972) Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 52:148-159
2. Alarcon-Segovia DA, Villarreal M (1987) Classification and diagnostic criteria for mixed connective tissue disease. In: Kasukawa R, Sharp GC (eds) Mixed connective tissue disease and anti-nuclear antibodies. Excerpta Medica, Amsterdam, pp 33-40
3. Smolen JS, Steiner G (1998) Mixed connective tissue disease: to be or not to be?. Arthritis Rheum 41:768-777
4. Hoffman RW, Greidinger EL (2000) Mixed connective tissue disease. Curr Opin Rheumatol 12:386-390
5. Sharp GC (1974) Mixed connective tissue disease. Bull Rheum Dis 25:828-831
6. Sullivan WD, Hurst DJ, Harmon CE, Esther JH (1984) A prospective evaluation emphasizing pulmonary involvement in patients with mixed connective tissue disease. Medicine 63:92-107
7. Eulderink F, Cats A (1981) Fatal pulmonary hypertension in mixed connective tissue disease. Z Rheumatol 40:25-29
8. Suzuki M, Hamada M, Sekiya M, Shigematsu Y, Go S, Hiwada K (1992) Fatal pulmonary hypertension in a patient with mixed connective tissue disease: report of an autopsy case. Intern Med 31:74-77
9. Ueda N, Mimura K, Sugiyama T, Kado T (1984) Mixed connective tissue disease with fatal pulmonary hypertension and a review of literature. Virchows Arch (Pathol Anat) 404:335-340
10. Hosoda T (1987) Review of pathology of mixed connective tissue disease. In: Kasukawa R, Sharp GC (eds) Mixed connective tissue disease and anti-nuclear antibodies. Excerpta Medica, Amsterdam, pp 281-290
11. Rosenberg AM, Petty RE, Cumming GR, Koechler B (1976) Pulmonary hypertension in a child with mixed connective tissue disease. J Rheumatol 6:700-704
12. Alpert MA, Goldberg SH, Singsen BH, Durham JB, Sharp GC, Ahmad M et al (1983) Cardiovascular manifestations of mixed connective tissue disease in adults. Circulation 68:1182-1193
13. Burdt MA, Hoffman RW, Deutscher SL, Wang GS (1999) Long-term outcome in mixed connective tissue disease: longitudinal clinical and serologic findings. Arthritis Rheum 42:899-909
14. Jones MB, Osterholm RK, Wilson RB, Martin FH, Commers JS, Bachmayer JD (1978) Fatal pulmonary hypertension and resolving immune-complex glomerulonephritis in mixed connective tissue disease. Am J Med 65:855-863
15. Wiener-Kronish JP, Solinger AM, Warnock ML, Churg A, Ordonez N, Golden JA (1981) Severe pulmonary involvement in mixed connective tissue disease. Am Rev Respir Dis 124:499-503
16. Manthorphe R, Elling H, van der Meulen JT, Freiesleben Sorensen S (1980) Two fatal cases of mixed connective tissue disease. Scand J Rheumatol 9:7-10
17. Prakash UBS (1988) Pulmonary manifestations in mixed connective tissue disease. Seminars Resp Med 9:318-324
18. Prakash UBS (1998) Respiratory complications in mixed connective tissue disease. Clin Chest Med 19:733-746
19. Schachna L, Wigley FM, Chang B, White B, Wise RA, Gelber AC (2003) Age and risk of pulmonary arterial hypertension in scleroderma. Chest 124:2098-2104
20. Mukerjee D, St. George D, Knight C, Davar J, Wells AU, Du Bois RM, Black CM, Coghlan JG (2004) Echocardiography and pulmonary function as creeening tests for pulmonary arterial hypertension in systemic sclerosis. Rheumatology 43:461-466
21. Ozawa T, Ninomiya Y, Honma T, Kikuchi M, Sato T, Nakano M, Arakawa M (1995) Increased serum angiotensin I-Converting enzyme activity in patients with mixed connective tissue disease and pulmonary hypertension. Scand J Rheumatol 24:38-43
22. Manganelli P, Salaffi F, Carotti M, Delsante G, Mozzani F (1999) Pulmonary hypertension in rheumatic diseases. Minerva Med 90:59-72
23. Miyata M, Suzuki K, Sakuma F, Watanabe H, Kaise S, Nishimaki T, Kasukawa R (1993) Anticardiolipin antibodies are associated with pulmonary hypertension in patients with mixed connective tissue disease or systemic lupus erythematosus. Int Arch Allergy Immunol 100:351-354
24. Sasaki N, Kurose A, Inoue H, Sawai T (2002) A possible role of anti-endothelial cell antibody in the sera of MCTD patients on pulmonary vascular damage relating to pulmonary hypertension. Ryumachi 42:885-894
25. Nishimaki T, Aotsuka S, Kondo H (1999) Immunological analysis of pulmonary hypertension in connective tissue diseases. J Rheumatol 26:2357-2362
26. Klings ES, Hill NS, Ieong MH, Sims RW, Korn JH, Farber HW (1999) Systemic sclerosis-associated pulmonary hypertension. Arthritis Rheum 42:2638-2645
27. Nicod LP (2003) Pulmonary hypertension. Swiss Med Wkly 133:103-110
28. Magliano M, Isenberg DA, Hillson J (2002) Pulmonary hypertension in autoimmune rheumatic diseases. Arthritis Rheum 46:1997-2009
29. Hoeper MM, Scharze M, Ehlerding S, Adler-Schuermeyer A, Spiekerkoetter E, Niedermeyer J (2000) Long-term treatment of primary pulmonary hypertension with aerosolised iloprost, a prostacyclin analogue. N Engl J Med 342:1866-1870
30. Della Bella S, Molteni M, Mocellin C, Fumagalli S, Bonara P, Scorza R (2001) Novel mode of action of Iloprost: in vitro downregulation of endothelial cell adhesion molecules. Prostaglandins 65:73-83
31. Bettoni L, Geri A, Airo P, Danieli E, Cavazzana I, Antonioli C, Chiesa L, Franceschini F, Grottolo A, Zambruni A, Radaeli E, Cattaneo R (2002) Systemic sclerosis therapy with Iloprost: A prospective observational study of 30 patients treated for a median of 3 years. Clin Rheumatol 21:244-250
32. Chouat A, Weitzenblum E, Higenbottam T (1996) The role of thrombosis in severe pulmonary hypertension. Eur Respir J 9:356-363
33. Mehta NJ, Khan IA, Mehta RN et al (2000) HIV related pulmonary hypertension. Chest 118:1133-1141
34. Rich S, Kaufman E, Levy PS (1992) The effect of high doses of calcium channel blockers on survival in primary pulmonary hypertension. N Engl J Med 327:76-81
35. Frank H, Mlczoch J, Huber K et al (1997) The effect of anti-coagulant therapy in primary and anorectic drug induced pulmonary hypertension. Chest 112:714-721
36. Kotajuma L, Aotsuka S, Sato T (1997) Clinical significance of serum thrombomodulin levels in patients with systemic rheumatic diseases. Clin Exp Rheumatol 15:59-65