General synthesis of tetrasubstituted alkenyl-1,3,4-oxadiazoles

Tetrahedron Letters

Volumn 47, Issue 4, 2006, Pages 511-514

  James, Clint A ^a   Poirier, Brigitte ^a   Grisé, Christiane ^a   Martel, Alain ^a   Ruediger, Edward H ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; BASE; BENZENE DERIVATIVE; FUNCTIONAL GROUP; HEXACHLOROETHANE; HYDRAZIDE DERIVATIVE;

ACYLATION; ARTICLE; CYCLIZATION; DRUG SYNTHESIS; METHODOLOGY;

EID: 29144474414     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.11.057     Document Type: Article

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45. +. Monoacylhydrazide 3 was prepared by EDCI/HOBt coupling of the corresponding acid with an excess of hydrazine monohydrate.
46. +.
47. Polanc has demonstrated a similar one-pot protocol for a limited number of substrates starting from monoacylhydrazides and isocyanates to give 2-amino-1,3,4-oxadiazoles (see Ref. 14).
48. +.