Walter elsasser, prophet of biological complexity, seeker of simplifying rules

Cellular and Molecular Biology

Volumn 51, Issue 7, 2005, Pages 599-606

  Rubin, H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biological theory; Growth regulation; Quantum mechanics

Indexed keywords

ARTICLE; CHEMICAL BOND; CONCEPTUAL FRAMEWORK; DNA STRAND; GENETIC SELECTION; GROWTH REGULATION; MEDICAL SPECIALIST; MOLECULAR BIOLOGY; QUANTUM MECHANICS;

ANIMALS; BIOLOGY; CELL GROWTH PROCESSES; GROWTH AND DEVELOPMENT; HISTORY, 20TH CENTURY; HUMANS; MODELS, BIOLOGICAL; PORTRAITS; QUANTUM THEORY; UNITED STATES;

EID: 29144474273     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: 10.1170/T669     Document Type: Article

References (35)

1. Achs, M.J., and Garfinkel, D., Computer simulation of energy metabolism in anoxic perfused rat heart. Am. J. Physiol. 1982, 232: R164-R174.
2. Bailey, C. H., Hawkins, R.D., and Kandel, E.R., Synaptic growth, synaptic maintenance and the persistence of long term memory storage. In: Cell Growth: Control of Cell Size, Hall M.N., Raff M. and Thomas, G. (eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 2004, pp. 31-472.
3. Bohr, N., Unity of knowledge. In: Atomic Physics and Human Knowledge, John Wiley and Sons, New York, 1958, pp. 67-82.
4. Bowen-Pope, D.F. and Rubin, H., Magnesium and calcium effects on uptake of hexoses and uridine by chick embryo fibroblasts. Proc. Natl. Acad. Sci. USA 1977, 74: 1585-1589.
5. Braakhuis, B.J.M., Leemans, C.R. and Brakenhoff, R.H., Expanding fields of genetically altered cells in head and neck squamous carcinogenesis. Sem. Cancer Biol. 2005, 15: 113-120.
6. Brash, D.E., Zhang, W., Grossman, D. and Takeuchi, S., Colonization of adjacent stem cell compartments by mutant keratinocytes. Sem. Cancer Biol. 2005, 15: 97-102.
7. Califano, J., van der Riet, P., Westra, W., Nawroz, H., Clayman, G., Piantadosi, S., Corio, R., Lee, D., Greenberg, B., Koch, W. and Sidransky, D., Genetic progression model for head and neck cancer: Implications for field cancerization. Cancer Res. 1996, 56: 2488-2492.
8. Dollé, M.E.T., Snyder, W.K., Gossen, J.A., Lohman, P.H.M. and Vijg, J., Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Proc. Natl. Acad. Sci. USA 2000, 97: 8403-8408.
9. Eddington, A., The Philosophy of Physical Science, University of Michigan Press, Ann Arbor, Michigan, 1939.
10. Elsasser, W.M., Memoirs of a Physicist in the Atomic Age, Science History Publ., Div. of Neale Watson Acad. Publ., NewYork, 1978.
11. Elsasser, W.M., Outline of a theory of cellular heterogeneity. Proc. Natl. Acad. Sci. USA 1984, 81: 5126-5129.
12. Elsasser, W.M., Reflections on a Theory of Organisms, Johns Hopkins Univ. Press, Baltimore, MD, 1998.
13. Grobstein, C. and Zwilling, E., Modification of growth and differentiation of chorioallantoic grafts of chick blastoderm pieces after cultivation at a glass-clot interface. J. Exp. Zool. 1953, 122: 259-284.
14. 2+ homeostasis in BC3H-1 myocytes. Am. J. Physiol. 1991, 260: C1158-C1164.
15. Horowitz, S.B. and Tluczek, L.J.M., Gonadotropin stimulates oocyte translation by increasing magnesium activity through intracellular potassium-magnesium exchange. Proc. Natl. Acad. Sci. USA 1989, 86: 9652-9656.
16. 2+ concentration in single Swiss 3T3 fibroblasts. Am. J. Physiol. 1991, 261: C1074-C1080.
17. Levinthal, J.D. and Rubin, H., Serum induced changes in the fine structure of primary chick embryo cultures. Exp. Cell Res. 1968, 52: 667-672.
18. Rodin, S.N. and Rodin, A.S., Origins and selection of p53 mutations in lung carcinogenesis. Sem. Cancer Biol. 2005, 15: 103-112.
19. Rozengurt, E., Stein, W.D. and Wigglesworth, N., Uptake of nucleosides in density-inhibited cultures of 3T3 cells. Nature 1977, 267: 442-444.
20. Rubin, H., Early origin and pervasiveness of cellular heterogeneity in some malignant transformations. Proc. Natl. Acad. Sci. USA 1984, 81: 5121-5125.
21. Rubin, H., Cancer as a dynamic developmental disorder. Cancer Res. 1985, 45: 2935-2942.
22. Rubin, H., 'Spontaneous' transformation as aberrant epigenesis. Differentiation 1993, 53: 123-137.
23. Rubin, H., The role of selection in progressive neoplastic transformation. Adv. Cancer Res. 2001, 83: 159-207.
24. Rubin, H., Central roles of Mg2+ and of MgATP2- in the regulation of protein synthesis and cell proliferation: significance for neoplastic transformation. Adv. Cancer Res. 2005, 93: 1-58.
25. Rubin, H., Magnesium: The missing element in molecular views of cell proliferation control. Bioessays 2005, 27: 311-320.
26. 2+ activity and suppresses the neoplastic phenotype. Sem. Cancer Biol. 2005, 15: 121-131.
27. Rubin, H., Chu, B.M. and Arnstein, P., Selection and adaptation for rapid growth in culture of cells from delayed sarcomas in mice. Cancer Res. 1987, 47: 486-492.
28. Rubin, H. and Hatié, C., Increase in the size of chick embryo cells upon cultivation in serum-containing medium. Dev. Biol. 1968, 17: 603-616.
29. Simpson, A.J.G., The natural somatic mutation frequency and human carcinogenesis. Adv. in Cancer Res. 1997, 71: 209-240.
30. Terasaki, M. and Rubin, H., Evidence that intracellular magnesium is present in cells at a regulatory concentration for protein synthesis. Proc. Natl. Acad. Sci. USA 1985, 82: 7324-7326.
31. 2+ as an intracellular regulator of uridine uptake. J. Cell. Physiol. 1981, 108: 317-325.
32. 2+ as activator of uridine phosphorylation and other cellular responses to growth factors. Proc. Natl. Acad. Sci. USA 2005, 102: 662-666.
33. Vijg, J., Dollé, M.E.T., Martus, H.J. and Boerrigter, M., Transgenic mouse models for studying mutations in vivo: applications in aging research. Mech. Ageing and Dev. 1997, 99: 257-271.
34. Weiss, P., The Science of Life, Futura Publ., Mt. Kisco, New York, 1973.
35. Weisskopf, V.F., Physics as natural philosophy. Nature 1979, 278: 759-760.