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Volumn 117, Issue 21-22, 2005, Pages 728-738

Strontium ranelate: A novel concept for the treatment of osteoporosis;Strontiumranelat - Ein neues konzept zur behandlung der osteoporose

Author keywords

Dual mode of action; Fracture; Osteoporosis; Ranelic acid; Strontium ranelate

Indexed keywords

CALCIUM; STRONTIUM RANELATE;

EID: 29144471280     PISSN: 00435325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00508-005-0471-3     Document Type: Review
Times cited : (10)

References (47)
  • 2
    • 0014733736 scopus 로고
    • Common strontium concentration of mineralized tissues from marine and sweet water animals
    • Rosenthal HL, Eves MM, Cochran OA (1970) Common strontium concentration of mineralized tissues from marine and sweet water animals. Comp Biochem Physiol 32: 491-450
    • (1970) Comp Biochem Physiol , vol.32 , pp. 491-1450
    • Rosenthal, H.L.1    Eves, M.M.2    Cochran, O.A.3
  • 3
    • 0037319807 scopus 로고    scopus 로고
    • Strontiumranelate: A new paradigm in the treatment of osteoporosis
    • Reginster JY, Deroisy R, Jupsin I (2003) Strontiumranelate: a new paradigm in the treatment of osteoporosis. Drugs Today 39: 89-101
    • (2003) Drugs Today , vol.39 , pp. 89-101
    • Reginster, J.Y.1    Deroisy, R.2    Jupsin, I.3
  • 4
    • 0002886842 scopus 로고
    • An attempt to quantitate the short-term movement of strontium in the human adult
    • Academic Press, London
    • Carr TF (1967) An attempt to quantitate the short-term movement of strontium in the human adult. In: Carr TF (ed) Strontium metabolism. Academic Press, London, pp 139-148
    • (1967) Carr TF (Ed) Strontium Metabolism , pp. 139-148
    • Carr, T.F.1
  • 6
    • 9144233479 scopus 로고    scopus 로고
    • The effects of Strontiumranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    • Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD, et al (2004) The effects of Strontiumranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 350: 459-468
    • (2004) N Engl J Med , vol.350 , pp. 459-468
    • Meunier, P.J.1    Roux, C.2    Seeman, E.3    Ortolani, S.4    Badurski, J.E.5    Spector, T.D.6
  • 7
    • 0000382164 scopus 로고
    • Competition between Kalzium, strontium and magnesium for absorption in the isolated rat intestine
    • Hendrix JZ, Alcock NW, Archibald RM (1963) Competition between Kalzium, strontium and magnesium for absorption in the isolated rat intestine. Clin Chem 9: 734-744
    • (1963) Clin Chem , vol.9 , pp. 734-744
    • Hendrix, J.Z.1    Alcock, N.W.2    Archibald, R.M.3
  • 8
    • 0015189865 scopus 로고
    • Reduction in absorption and retention of strontium in rats
    • Slat B, Kostial K, Harrisson GE (1971) Reduction in absorption and retention of strontium in rats. Health Phys 21: 811-814
    • (1971) Health Phys , vol.21 , pp. 811-814
    • Slat, B.1    Kostial, K.2    Harrisson, G.E.3
  • 9
    • 0000783559 scopus 로고
    • Content of stable strontium in man and animal biota
    • Skoryna SC (ed). Plenum Press, New York
    • Rosenthal HL (1981) Content of stable strontium in man and animal biota. In: Skoryna SC (ed) Handbook of stable strontium. Plenum Press, New York, pp 503-514
    • (1981) Handbook of Stable Strontium , pp. 503-514
    • Rosenthal, H.L.1
  • 10
    • 0029812110 scopus 로고    scopus 로고
    • Strontium distribution and interactions with the bone mineral in monkey iliac bone after strontium salt (S12911) administration
    • Boivin G, Deloffre P, Perrat B, Panczer G, Boudeulle M, Tsouderos Y, et al (1996) Strontium distribution and interactions with the bone mineral in monkey iliac bone after strontium salt (S12911) administration. J Bone Miner Res 11: 1302-1311
    • (1996) J Bone Miner Res , vol.11 , pp. 1302-1311
    • Boivin, G.1    Deloffre, P.2    Perrat, B.3    Panczer, G.4    Boudeulle, M.5    Tsouderos, Y.6
  • 11
    • 0025053086 scopus 로고
    • Effects of low doses of strontium on bone quality and quantity in rats
    • Grynpas MD, Marie PJ (1990) Effects of low doses of strontium on bone quality and quantity in rats. Bone 11: 313-319
    • (1990) Bone , vol.11 , pp. 313-319
    • Grynpas, M.D.1    Marie, P.J.2
  • 12
    • 0028276804 scopus 로고
    • Strontium alters the complexed acidic phospholipid content of mineralizing tissues
    • Neufeld EB, Boskey AL (1994) Strontium alters the complexed acidic phospholipid content of mineralizing tissues. Bone 15: 425-430
    • (1994) Bone , vol.15 , pp. 425-430
    • Neufeld, E.B.1    Boskey, A.L.2
  • 13
    • 0029960972 scopus 로고    scopus 로고
    • Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect
    • Grynpas MD, Hamilton E, Cheung R, Tsouderos Y, Deloffre P, Hott M, Marie PJ (1996) Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect. Bone 18: 253-259
    • (1996) Bone , vol.18 , pp. 253-259
    • Grynpas, M.D.1    Hamilton, E.2    Cheung, R.3    Tsouderos, Y.4    Deloffre, P.5    Hott, M.6    Marie, P.J.7
  • 15
    • 0038458741 scopus 로고    scopus 로고
    • Dose-dependent effects of strontium on osteoblast function and mineralization
    • Verberckmoes SC, De Broe ME, D'Haese PC (2003) Dose-dependent effects of strontium on osteoblast function and mineralization. Kidney Int 64: 534-543
    • (2003) Kidney Int , vol.64 , pp. 534-543
    • Verberckmoes, S.C.1    De Broe, M.E.2    D'Haese, P.C.3
  • 17
    • 0037231949 scopus 로고    scopus 로고
    • Strontium and osteomalacia in renal failure patients
    • De Broe ME, D'Haese PC (2003) Strontium and osteomalacia in renal failure patients. Nephrol Dial Transplant 18: 215-216
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 215-216
    • De Broe, M.E.1    D'Haese, P.C.2
  • 19
    • 24144474976 scopus 로고    scopus 로고
    • Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralisation of bone
    • WebFirst
    • Farley D, Boivin G, Panczer G, Lalande A, Meunier PJ (2005) Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralisation of bone. J Bone Miner Res (WebFirst)
    • (2005) J Bone Miner Res
    • Farley, D.1    Boivin, G.2    Panczer, G.3    Lalande, A.4    Meunier, P.J.5
  • 20
    • 0014389146 scopus 로고
    • The incorporation and removal of large amounts of strontium by physiologic mechanisms in mineralized tissues
    • Johnson AR, Armstrong WD, Singer L (1968) The incorporation and removal of large amounts of strontium by physiologic mechanisms in mineralized tissues. Calcif Tissue Res 2: 242-252
    • (1968) Calcif Tissue Res , vol.2 , pp. 242-252
    • Johnson, A.R.1    Armstrong, W.D.2    Singer, L.3
  • 22
    • 0000848891 scopus 로고
    • The strontium salt S12911 inhibits bone resorption in mouse calvaria and isolated rat osteoclast cultures
    • Su Y, Bonnet J, Deloffre P, Tsouderos Y, Baron R (1992) The strontium salt S12911 inhibits bone resorption in mouse calvaria and isolated rat osteoclast cultures. Bone Miner 17 [Suppl 1]: 188
    • (1992) Bone Miner , vol.17 , Issue.SUPPL. 1 , pp. 188
    • Su, Y.1    Bonnet, J.2    Deloffre, P.3    Tsouderos, Y.4    Baron, R.5
  • 23
    • 0142122898 scopus 로고    scopus 로고
    • S 12911-2 inhibits osteoclastic bone resorption in vitro
    • Takahashi N, Sasaki T, Tsouderos Y, Suda T (2003) S 12911-2 inhibits osteoclastic bone resorption in vitro. J Bone Miner Res 18: 1082-1087
    • (2003) J Bone Miner Res , vol.18 , pp. 1082-1087
    • Takahashi, N.1    Sasaki, T.2    Tsouderos, Y.3    Suda, T.4
  • 24
    • 0037118899 scopus 로고    scopus 로고
    • In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation
    • Baron R, Tsouderos Y (2002) In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol 450: 11-17
    • (2002) Eur J Pharmacol , vol.450 , pp. 11-17
    • Baron, R.1    Tsouderos, Y.2
  • 25
    • 0030176233 scopus 로고    scopus 로고
    • The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro
    • Canalis E, Hott M, Deloffre P, Tsouderos Y, Marie PJ (1996) The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Bone 18: 517-523
    • (1996) Bone , vol.18 , pp. 517-523
    • Canalis, E.1    Hott, M.2    Deloffre, P.3    Tsouderos, Y.4    Marie, P.J.5
  • 27
    • 12544251402 scopus 로고    scopus 로고
    • Drugs used to treat osteoporosis: The critical need for a uniform nomenclature based on their action on bone remodeling
    • Riggs BL, Parfitt AM (2005) Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling. J Bone Miner Res 20: 177-184
    • (2005) J Bone Miner Res , vol.20 , pp. 177-184
    • Riggs, B.L.1    Parfitt, A.M.2
  • 28
    • 0036068720 scopus 로고    scopus 로고
    • Long-term treatment with Strontiumranelate increases vertebral bone mass without deleterious effect in mice
    • Delannoy P, Bazot D, Marie PJ (2002) Long-term treatment with Strontiumranelate increases vertebral bone mass without deleterious effect in mice. Metabolism 51: 906-911
    • (2002) Metabolism , vol.51 , pp. 906-911
    • Delannoy, P.1    Bazot, D.2    Marie, P.J.3
  • 29
    • 0000424759 scopus 로고
    • Effects of strontium salt (S12911) on both tibial metaphysis and epiphysis in normal growing rats
    • Arlot ME, Roux JP, Boivin G (1995) Effects of strontium salt (S12911) on both tibial metaphysis and epiphysis in normal growing rats. J Bone Miner Res 10: 356
    • (1995) J Bone Miner Res , vol.10 , pp. 356
    • Arlot, M.E.1    Roux, J.P.2    Boivin, G.3
  • 30
    • 0001164063 scopus 로고
    • Long-term administration of a high dose of the strontium salt S12911 has no toxic effect on bone biomechanics in female rats and may improve bone strength of the midshaft humerus
    • Amman P, Rizzoli R, Deloffre P, Tsouderos Y, Meyer JM, Bonjour JP (1995) Long-term administration of a high dose of the strontium salt S12911 has no toxic effect on bone biomechanics in female rats and may improve bone strength of the midshaft humerus. J Bone Miner Res 10: 358
    • (1995) J Bone Miner Res , vol.10 , pp. 358
    • Amman, P.1    Rizzoli, R.2    Deloffre, P.3    Tsouderos, Y.4    Meyer, J.M.5    Bonjour, J.P.6
  • 31
    • 0000177013 scopus 로고    scopus 로고
    • The increase in vertebral bone mass induced in intact rats by long-term administration of the strontium salt S12911 is directly correlated with vertebral bone strength
    • Amman P, Rizzoli R, Deloffre P, Tsouderos Y, Meyer JM, Bonjour JP (1996) The increase in vertebral bone mass induced in intact rats by long-term administration of the strontium salt S12911 is directly correlated with vertebral bone strength. Osteoporios Int 6 (S1): 259
    • (1996) Osteoporios Int , vol.6 , Issue.S1 , pp. 259
    • Amman, P.1    Rizzoli, R.2    Deloffre, P.3    Tsouderos, Y.4    Meyer, J.M.5    Bonjour, J.P.6
  • 32
    • 0000395569 scopus 로고    scopus 로고
    • Long-term exposure to strontiumranelate dose-dependently increases bone strength in intact female rats
    • Amman P, Robin B, Bonjour JP, Tupinon-Mathieu I, Meyer JM, Rizzoli R (2001) Long-term exposure to strontiumranelate dose-dependently increases bone strength in intact female rats. Bone 28 [Suppl]: S220
    • (2001) Bone , vol.28 , Issue.SUPPL.
    • Amman, P.1    Robin, B.2    Bonjour, J.P.3    Tupinon-Mathieu, I.4    Meyer, J.M.5    Rizzoli, R.6
  • 33
    • 0034902167 scopus 로고    scopus 로고
    • Strontiumranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fasciclularis)
    • Buehler J, Chappuis P, Saffar JL, Tsouderos Y, Vignery A (2001) Strontiumranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fasciclularis). Bone 29: 176-179
    • (2001) Bone , vol.29 , pp. 176-179
    • Buehler, J.1    Chappuis, P.2    Saffar, J.L.3    Tsouderos, Y.4    Vignery, A.5
  • 34
    • 0028999383 scopus 로고
    • Effects of strontium on calcium metabiolism in rats II. Strontium prevents the increased rate of bone turnover in ovariectomized rats
    • Morohashi T, Sano T, Harai K, Yamada S (1995) Effects of strontium on calcium metabiolism in rats II. Strontium prevents the increased rate of bone turnover in ovariectomized rats. Jpn J Pharmacol 68: 153-159
    • (1995) Jpn J Pharmacol , vol.68 , pp. 153-159
    • Morohashi, T.1    Sano, T.2    Harai, K.3    Yamada, S.4
  • 35
    • 0027316220 scopus 로고
    • An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats
    • Marie PJ, Hott M, Modrowski D, De Pollak C, Guillemain J, Deloffre P, et al (1993) An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats. J Bone Miner Res 8: 607-615
    • (1993) J Bone Miner Res , vol.8 , pp. 607-615
    • Marie, P.J.1    Hott, M.2    Modrowski, D.3    De Pollak, C.4    Guillemain, J.5    Deloffre, P.6
  • 36
    • 0001030127 scopus 로고
    • S12911, a new agent containing strontium, inhibits bone loss due to immobilization in rats
    • Marie PJ, Hott M, Modrowski D (1995) S12911, a new agent containing strontium, inhibits bone loss due to immobilization in rats. J Bone Miner Res 10 (S 1): 105
    • (1995) J Bone Miner Res , vol.10 , Issue.S1 , pp. 105
    • Marie, P.J.1    Hott, M.2    Modrowski, D.3
  • 37
    • 0037381704 scopus 로고    scopus 로고
    • The hunting of the snark: The elusive calcium receptor(s)
    • Raisz LG (2003) The hunting of the snark: the elusive calcium receptor(s). J Clin Invest 111: 945-947
    • (2003) J Clin Invest , vol.111 , pp. 945-947
    • Raisz, L.G.1
  • 38
    • 0037382146 scopus 로고    scopus 로고
    • Rescue of the skeletal phenotype in CASR-deficient mice by transfer onto the Gcm2 null background
    • Tu Q, Pi M, Karsenty G, Simpson L, Liu S, Quarles LD (2003) Rescue of the skeletal phenotype in CASR-deficient mice by transfer onto the Gcm2 null background. J Clin Invest 111: 1029-1037
    • (2003) J Clin Invest , vol.111 , pp. 1029-1037
    • Tu, Q.1    Pi, M.2    Karsenty, G.3    Simpson, L.4    Liu, S.5    Quarles, L.D.6
  • 39
    • 0034602961 scopus 로고    scopus 로고
    • Sensing of extracellular cations in CASR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism
    • Pi M, Garner SC, Flannery P, Spurney RF, Quarles LD (2000) Sensing of extracellular cations in CASR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. J Biol Chem 275: 3256-3263
    • (2000) J Biol Chem , vol.275 , pp. 3256-3263
    • Pi, M.1    Garner, S.C.2    Flannery, P.3    Spurney, R.F.4    Quarles, L.D.5
  • 40
    • 3242810659 scopus 로고    scopus 로고
    • A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium
    • Pi M, Quarles LD (2004) A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium. I Bone Miner Res 19: 862-869
    • (2004) I Bone Miner Res , vol.19 , pp. 862-869
    • Pi, M.1    Quarles, L.D.2
  • 41
    • 0036766034 scopus 로고    scopus 로고
    • Dual energy X-ray absorptiometry and its clinical applications
    • Blake GM, Fogelman I (2002) Dual energy X-ray absorptiometry and its clinical applications. Semin Musculoskelet Radiol 6: 207-217
    • (2002) Semin Musculoskelet Radiol , vol.6 , pp. 207-217
    • Blake, G.M.1    Fogelman, I.2
  • 42
    • 21044447888 scopus 로고    scopus 로고
    • Strontiumranelate reduces the risk of nonvertebral fractures in post-menopausal women with osteoporosis: TROPOS Study
    • Reginster JY, Seeman E, DE Vernejoul MC, Adami S, Compston J, Phenekos C, et al (2005) Strontiumranelate reduces the risk of nonvertebral fractures in post-menopausal women with osteoporosis: TROPOS Study. J Clin Endocrinol Metab 90: 2816-2822
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2816-2822
    • Reginster, J.Y.1    Seeman, E.2    De Vernejoul, M.C.3    Adami, S.4    Compston, J.5    Phenekos, C.6
  • 43
    • 0002214158 scopus 로고
    • The usefulness of strontium as an adjuvant to calcium in the remineralization of the skeleton in man
    • Shorr E, Carter AC (1952) The usefulness of strontium as an adjuvant to calcium in the remineralization of the skeleton in man. Bull Hosp Joint Dis 13: 59-66
    • (1952) Bull Hosp Joint Dis , vol.13 , pp. 59-66
    • Shorr, E.1    Carter, A.C.2
  • 44
    • 0001293466 scopus 로고
    • The effect of strontium lactate in the treatment of osteoporosis
    • McCaslin FE Jr, Janes JM (1959) The effect of strontium lactate in the treatment of osteoporosis. Proc Staff Meetings Mayo Clin 34: 329-334
    • (1959) Proc Staff Meetings Mayo Clin , vol.34 , pp. 329-334
    • McCaslin Jr., F.E.1    Janes, J.M.2
  • 45
    • 0019817218 scopus 로고
    • Effects of oral supplementation with stable strontium
    • Skoryna SC (1981) Effects of oral supplementation with stable strontium. Can Med Assoc J 125: 703-712
    • (1981) Can Med Assoc J , vol.125 , pp. 703-712
    • Skoryna, S.C.1
  • 46
    • 18344379873 scopus 로고    scopus 로고
    • Strontiumranelate: Dose-dependent effects in established postmenopausal vertebral osteoporosis - A 2-year randomized placebo controlled trial
    • Meunier PJ, Slosman DO, Delmas PD, Sebert JL, Brandi ML, Albanese C, et al (2002) Strontiumranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis - a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 87: 2060-2066
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2060-2066
    • Meunier, P.J.1    Slosman, D.O.2    Delmas, P.D.3    Sebert, J.L.4    Brandi, M.L.5    Albanese, C.6
  • 47
    • 0141834679 scopus 로고    scopus 로고
    • Design and methodology of the phase 3 trials for the clinical development of Strontiumranelate in the treatment of women with postmenopausal osteoporosis
    • Meunier PJ, Reginster JY (2003) Design and methodology of the phase 3 trials for the clinical development of Strontiumranelate in the treatment of women with postmenopausal osteoporosis. Osteoporos Int 14 [Suppl 3]: S66-76
    • (2003) Osteoporos Int , vol.14 , Issue.SUPPL. 3
    • Meunier, P.J.1    Reginster, J.Y.2


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