Nongenomic responses to 17β-estradiol in male rat mesenteric arteries abolish intrinsic gender differences in vascular responses

British Journal of Pharmacology

Volumn 146, Issue 8, 2005, Pages 1148-1155

  Keung, Wendy ^a   Vanhoutte, Paul M ^a   Man, Ricky Y K ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

17 estradiol; Contraction; Gender; Nongenomic; Rat mesenteric arteries; Relaxation; Vascular smooth muscle

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; APAMIN; CHARYBDOTOXIN; ESTRADIOL; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HYPERPOLARIZATION; MALE; MESENTERIC ARTERY; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; VASODILATATION; ANIMAL; COMPARATIVE STUDY; DOSE RESPONSE; IN VITRO STUDY; SPRAGUE DAWLEY RAT; SUPERIOR MESENTERIC ARTERY; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ACETYLCHOLINE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ESTRADIOL; FEMALE; MALE; MESENTERIC ARTERIES; MESENTERIC ARTERY, SUPERIOR; MUSCLE, SMOOTH, VASCULAR; NITROPRUSSIDE; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 28944451629     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706422     Document Type: Article

References (36)

1. AKISHITA, M., KOZAKI, K., ETO, M., YOSHIZUMI, M., ISHIKAWA, M., TOBA, K., ORIMO, H. & OUCHI, Y. (1998). Estrogen attenuates endothelin-1 production by bovine endothelial cells via estrogen receptor. Biochem. Biophys. Res. Commun., 251, 17-21.
2. ASANO, K., MARUYAMA, S., USUI, T. & FUJIMOTO, N. (2003). Regulation of estrongen receptor alpha and beta expression by testosterone in the rat prostate gland. Endocr. J., 50, 281-287.
3. BAUERSACHS, J., POPP, R., HECKER, M., SAUER, E., FLEMING, I. & BUSSE, R. (1996). Nitric oxide attenuates the release of endotheliura-derived hyperpolarizing factor. Circulation, 94, 3341-3347.
4. CHEN, Z., YUHANNA, I.S., GALCHEVA-GARGOVA, Z., KARAS, R.H., MENDELSOHN, M.E. & SHAUL, P.W. (1999). Estrogen receptor α mediates the nongenomic activation of endothelial NO synthase by estrogen. J. Clin. Invest., 103, 401-406.
5. 2+ entry mechanisms of arterial vasoconstriction by sex hormones. Clin. Exp. Pharmacol. Physiol., 26, 707-715.
6. FIGTREE, G.A., MCDONALD, D., WATKINS, H. & CHANNON, K.M. (2003). Truncated estrogen receptor α 46-kDa isoform in human endothelial cells: relationship to acute activation of nitric oxide synthase. Circulation, 107, 120-126.
7. FORTE, P., KNEALE, B.J., MILNE, E., CHOWIENCZYK, P.J. & JOHNSTON, A. (1998). Evidence for a difference in nitric oxide biosynthesis between healthy women and men. Hypertension, 32, 730-734.
8. GEARY, G.G., KRAUSE, D.N. & DUCKLES, S.P. (2000). Estrogen reduces mouse cerebral artery tone through endothelial NOS- and cyclooxygenase-dependent mechanisms. Am. J. Physiol. Heart Circ. Physiol., 279, H511-H519.
9. GOYAL, H.O., BARTOL, F.F., WILEY, A.A., KHALIL, M.K., WILLIAMS, C.S. & VIG, M.M. (1998). Regulation of androgen and estrogen receptors in male excurrent ducts of the goat: an immunohistochemical study. Anat Rec., 250, 164-171.
10. HAYNES, M.P., SINHA, D., RUSSELL, K.S., COLLINGE, M., FULTON, D., MORALES-RUIZ, M., SESSA, W.C. & BENDER, J.R. (2000). Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ. Res., 87, 677-682.
11. KÄHÖNEN, M., TOLVANEN, J.P., SALLINEN, K., WU, X. & PORSTI, I. (1998). Influence of gender on control of arterial tone in experimental hypertension. Am. J. Physiol. Heart Circ. Physiol., 275, H15-H22.
12. KANASHIRO, C.A. & KHALIL, R.A. (2001). Gender-related distinctions in protein kinsae C activity in rat vascular smooth muscle. Am. J. Physiol. Cell Physiol., 280, C34-C45.
13. KELLY, M.J. & LEVIN, E.R. (2001). Rapid actions of plasma membrane estrogen receptors. Trends Endocrinol. Metab., 12, 152-156.
14. KEUNG, W., VANHOUTTE, P.M. & MAN, R.Y. (2005). Acute impairment of contractile responses by 17beta-estradiol is cAMP and protein kinase G dependent in vascular smooth muscle cells of the porcine coronary arteries. Br. J. Pharmacol., 144, 71-79.
15. KHOURY, S., YAROWS, S.A., O'BRIEN, T.K. & SOWERS, J.R. (1992). Ambulatory blood pressure monitoring in a nonacademic setting: effects of age and sex. Am. J. Hypertens., 5, 616-623.
16. MAGGI, A., CIGNARELLA, A., BRUSADELLI, A., BOLEGO, C., PINNA, C. & PUGLISI, L. (2003). Diabetes undermines estrogen control of inducible nitric oxide synthase function in rat aortic smooth muscle cells through overexpression of estrogen receptor-beta. Circulation, 108, 211-217.
17. MARTINEZ, C., SANCHEZ, M., HIDALGO, A. & GARCIA DE BOTO, M.J. (2001). Involvement of K(ATP) channels in diethylstilbestrol-induced relaxation in rat aorta. Eur. J. Pharm., 413, 109-116.
18. MAYHAN, W.G., SUN, H. & IRVINE, S.D. (2002). Influence of gender on dilatation of the basilar artery during diabetes mellitus. Brain Res, 930, 182-190.
19. MCCULLOCH, A.I., BOTTRILL, F.E., RANDALL, M.D. & HILEY, R. (1997). Characterization and modulation of EDHF-mediated relaxations in the rat isolated superior mesenteric arterial bed. Br. J. Pharmacol., 120, 1431-1438.
20. MCCULLOCH, A.I. & RANDALL, M.D. (1998). Sex differences in the relative contributions of nitric oxide and EDHF to agonist-stimulated endothelium-dependent relaxations in the rat isolated mesenteric arterial bed. Br. J. Pharmacol., 123, 1700-1706.
21. MCKEE, A.P., VAN RIPER, D.A., DAVISON, C.A. & SINGER, H.A. (2003). Gender-dependent modulation of 1-adrenergic responses in rat mesenteric arteries. Am. J. Physiol. Heart Circ. Physiol., 284, H1737-H1743.
22. 2+] in vascular smooth muscle cells of female rat. Am. J. Physiol. Cell Physiol., 278, C834-C844.
23. OLMOS, L., MOMBOULI, J.-V., ILLIANO, S. & VANHOUTTE, P.M. (1995). cGMP mediates the desensitization to bradykinin in isolated canine coronary arteries. Am. J. Physiol., 268, H865-H870.
24. PAREDES-CARBAJAL, M.C., JULIREZ-OROPEZA, M.A., ORTIZ-MENDOZA, C.M. & MASCHER, D. (1995). Effects of acute and chronic estrogenic treatment on vasomotor responses of aortic rings from ovariectomized rats. Life Sci., 57, 473-486.
25. ROSANO, G.M., SARREL, P.M., POOLE-WILSON, P.A. & COLLINS, P (1993). Beneficial effect of oestrogen on exercise-induced myocardial ischaemia in women with coronary artery disease. Lancet, 342, 133-136.
26. SAKUMA, I., LIU, M.-Y., SATO, A., HAYASHI, T., IGUCHI, A., KITABATAKE, A. & HATTORI, Y. (2002). Endothelium-dependent hyperpolarization and relaxation in mesenteric arteries of middle-aged rats: influence of oestrogen. Br. J. Pharmacol., 135, 48-54.
27. SHAW, L., TAGGART, M.J. & AUSTIN, C. (2000). Mechanisms of 17β-oestradiol induced vasodilatation in isolated pressurized rat small arteries. Br. J. Pharmacol., 129, 555-565.
28. SOMLYO, A.P. & SOMLYO, A.V. (2000). Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and nonmuscle myosin II. J. Physiol. (London), 522, 177-185.
29. STALLONE, J.N. (1993). Role of endothelium in sexual dimorphism in vasopressin-induced contraction of rat aorta. Am. J. Physiol., 265, H2073-H2080.
30. STEFANO, G.B., PREVOT, V., BEAUVILLAIN, J.-C., CADET, P., FIMIANI, C., WELTERS, I., FRICCHIONE, G.L., BRETON, C., LASSALLE, P., SALZET, M. & BILFINGER, T.V. (2000). Cell-surface estrogen receptors mediate calcium-dependent nitric oxide release in human endothelia. Circulation, 101, 1594-1597.
31. TEOH, H., LEUNG, S.W.S. & MAN, R.Y.K. (1999). Short-term exposure to physiological levels of 17 beta-estradiol enhances endothelium-independent relaxation in porcine coronary artery. Cardiovasc. Res., 42, 224-231.
32. TEP-AREENAN, P., KENDALL, D.A. & RANDALL, M.D. (2003). Mechanisms of vasorelaxation to 17β-oestradiol in rat arteries. Eur. J. Pharmacol., 478, 139-149.
33. WHITE, R.E., DARKOW, D.J. & LANG, J.L. (1995). Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism. Circ. Res., 77, 936-942.
34. WIINBER, N., HOEGHOLM, A., CHRISTENSEN, H.R., BANG, L.E., MIKKELSEN, K.L., NIELSEN, P.E., SVENDSEN, T.L., KAMPMANN, J.P., MADSEN, N.H. & BENTZON, M.W. (1995). 24-h Ambulatory blood pressure in 352 normal Danish subjects, related to age and gender. Am. J. Hypertens., 8, 978-986.
35. ZHANG, Y & DAVIDGE, S.T. (1999). Effect of estrogen replacement on vasoconstrictor responses in rat mesenteric arteries. Hypertension, 34, 1117-1122.
36. ZYGMUNT, P.M. & HÖGESTÄTT, E.D. (1996). Role of potassium channels in endothelium-dependent relaxation resistant to nitro-arginine in the rat hepatic artery. Br. J. Pharmacol., 117, 1600-1606.