A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach

Journal of Human Genetics

Volumn 50, Issue 12, 2005, Pages 607-610

  Johnson, Matthew P ^a   Griffiths, Lyn R ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

DNA pooling; Genetic association; Migraine; Serotonin

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINO ACID DECARBOXYLASE; DNA; TRYPTOPHAN HYDROXYLASE;

ARTICLE; BIOSYNTHESIS; DISEASE PREDISPOSITION; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE FREQUENCY; GENE LOCUS; GENETIC ANALYSIS; HUMAN; MEDICAL ASSESSMENT; MIGRAINE; NEUROTRANSMISSION; NOCICEPTION; PATHOPHYSIOLOGY; SEROTONINERGIC SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM REPEAT;

AROMATIC-L-AMINO-ACID DECARBOXYLASES; CHI-SQUARE DISTRIBUTION; GENE FREQUENCY; GENE POOL; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MIGRAINE DISORDERS; MONOAMINE OXIDASE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; SEROTONIN; TRYPTOPHAN HYDROXYLASE; VARIATION (GENETICS);

EID: 28844470326     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-005-0301-5     Document Type: Article

References (21)

1. Anthony M (1987) Amine metabolism in migraine. In: Blau JN (ed) Migraine. Clinical, therapeutic, conceptual and research aspects. Chapman and Hall, London, pp 303-330
2. Chugani DC, Niimura K, Chaturvedi S, Muzik O, Fakhouri M, Lee ML, Chugani HT (1999) Increased brain serotonin synthesis in migraine. Neurology 53:1473-1479
3. Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D, Nothen MM, Maffei P, Franke P, Fritze J, Maier W, Propping P, Beckmann H, Bellodi L, Lesch KP (1999) Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet 8:621-624
4. Ferrari MD, Odink J, Tapparelli C, Van Kempen GM, Pennings EJ, Bruyn GW (1989) Serotonin metabolism in migraine. Neurology 39:1239-1242
5. Ferrari MD, Saxena PR (1993) On serotonin and migraine: a clinical and pharmacological review. Cephalalgia 13:151-165
6. Headache Classification Committee of the International Headache Society (1988) Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 8(Suppl 7):1-96
7. Hoogendoorn B, Norton N, Kirov G, Williams N, Hamshere ML, Spurlock G, Austin J, Stephens MK, Buckland PR, Owen MJ, O'Donovan MC (2000) Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Hum Genet 107:488-493
8. Johnson MP, Haupt LM, Griffiths LR (2004) Locked nucleic acid (LNA) single nucleotide polymorphism (SNP) genotype analysis and validation using real-time PCR. Nucleic Acids Res 32:e55
9. Johnson MP, Lea RA, Curtain RP, MacMillan JC, Griffiths LR (2003) An investigation of the 5-HT2C receptor gene as a migraine candidate gene. Am J Med Genet 117B:86-89
10. Le Hellard S, Ballereau SJ, Visscher PM, Torrance HS, Pinson J, Morris SW, Thomson ML, Semple CA, Muir WJ, Blackwood DH, Porteous DJ, Evans KL (2002) SNP genotyping on pooled DNAs: comparison of genotyping technologies and a semi-automated method for data storage and analysis. Nucleic Acids Res 30:e74
11. Lea RA, Dohy A, Jordan K, Quinlan S, Brimage PJ, Griffiths LR (2000) Evidence for allelic association of the dopamine beta-hydroxylase gene (DBH) with susceptibility to typical migraine. Neurogenetics 3:35-40
12. Marziniak M, Mossner R, Benninghoff J, Syagailo YV, Lesch KP, Sommer C (2004) Association analysis of the functional monoamine oxidase A gene promotor polymorphism in migraine. J Neural Transm 111:603-609
13. Norton N, Williams NM, O'Donovan MC, Owen MJ (2004) DNA pooling as a tool for large-scale association studies in complex traits. Ann Med 36:146-152
14. Nyholt DR, Curtain RP, Gaffney PT, Brimage P, Goadsby PJ, Griffiths LR (1996) Migraine association and linkage analyses of the human 5-hydroxytryptamine (5HT2A) receptor gene. Cephalalgia 16:463-467
15. Paoloni-Giacobino A, Mouthon D, Lambercy C, Vessaz M, Coutant-Zimmerli S, Rudolph W, Malafosse A, Buresi C (2000) Identification and analysis of new sequence variants in the human tryptophan hydroxylase (TpH) gene. Mol Psychiatry 5:49-55
16. Sabol SZ, Hu S, Hamer D (1998) A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 103:273-279
17. Serretti A, Cristina S, Lilli R, Cusin C, Lattuada E, Lorenzi C, Corradi B, Grieco G, Costa A, Santorelli F, Barale F, Nappi G, Smeraldi E (2002) Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders. Am J Med Genet 114:361-369
18. Sham P, Bader JS, Craig I, O'Donovan M, Owen M (2002) DNA Pooling: a tool for large-scale association studies. Nat Rev Genet 3:862-871
19. Sham PC, Curtis D (1995) Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 59(Pt 1):97-105
20. Speight G, Turic D, Austin J, Hoogendoorn B, Cardno AG, Jones L, Murphy KC, Sanders R, McCarthy G, Jones I, McCandless F, McGuffin P, Craddock N, Owen MJ, Buckland P, O'Donovan MC (2000) Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Mol Psychiatry 5:327-331
21. Visscher PM, Le Hellard S (2003) Simple method to analyze SNP-based association studies using DNA pools. Genet Epidemiol 24:291-296