A potent and selective tacrine analog - Biomembrane permeation and physicochemical characterization

Pharmaceutical Development and Technology

Volumn 10, Issue 4, 2005, Pages 525-538

  Patani, George A ^a,b   Yuan, Ping Pang ^c   Chien, Yie W ^a,d  

^a RUTGERS UNIVERSITY   (United States)

^b Dr Patani Scientific and Industrial Research   (India)

^c MAYO CLINIC CANCER CENTER   (United States)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

AD treatment; Alzheimer's disease; Biomembrane permeation; Bis tacrine analogs; Brain targeting delivery; Cholinesterase inhibitors; Mucosal permeability; Physicochemical properties; Tacrine analogs

Indexed keywords

CHOLINESTERASE INHIBITOR; TACRINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STABILITY; KINETICS; LIPOPHILICITY; MEMBRANE TRANSPORT; NONHUMAN; NOSE MUCOSA; OLFACTORY SYSTEM; PARTITION COEFFICIENT; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SWINE; TEMPERATURE;

ANIMALS; BUFFERS; CELL MEMBRANE PERMEABILITY; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; INTESTINAL MUCOSA; MALE; MOUTH MUCOSA; SKIN; SKIN ABSORPTION; SOLUBILITY; SUS SCROFA; TACRINE;

EID: 28844453300     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450500333179     Document Type: Article

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