Tissue plasminogen activator-induced ischemic injury is reversed by NMDA antagonist MK-801 in vivo

Neurodegenerative Diseases

Volumn 2, Issue 2, 2005, Pages 49-55

  Kilic, Ertugrul ^a   Kilic, Ülkan ^a   Bähr, Mathias ^b   Hermann, Dirk M ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Ionotropic glutamate receptor; Middle cerebral artery occlusion; Thrombolysis

Indexed keywords

DIZOCILPINE; INDUCIBLE NITRIC OXIDE SYNTHASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEURONAL NITRIC OXIDE SYNTHASE; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD GAS ANALYSIS; BRAIN EDEMA; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; DRUG INTERACTIONS; EXCITATORY AMINO ACID AGONISTS; IMMUNOHISTOCHEMISTRY; LASER-DOPPLER FLOWMETRY; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; TISSUE PLASMINOGEN ACTIVATOR;

EID: 28744455421     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000089283     Document Type: Article

References (17)

1. NINDS Stroke Study Group: Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581-1587.
2. Wang YF, Tsirka SE, Strickland S, Stieg PE, Soriano SG, Lipton SA: Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med 1998;4:228-231.
3. Kilic E, Bähr M, Hermann DM: Effects of recombinant tissue plasminogen activator after intraluminal thread occlusion in mice: role of hemodynamic alterations. Stroke 2001; 32: 2641-2647.
4. Kilic E, Kilic Ü, Matter CM, Lüscher TF, Bassetti CL, Hermann DM: Aggravation of focal cerebral ischemia by tissue plasminogen activator is reversed by HMG-CoA reductase inhibitor, but does not depend on endothelial NO synthase. Stroke 2005;36:332-336.
5. Nicole O, Docagne F, Ali C, Margaill I, Carmeliet P, MacKenzie ET, Vivien D, Buisson A: The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signalling. Nat Med 2001;7:59-64.
6. Chalimoniuk M, Strosznajder J: NMDA receptor-dependent nitric oxide and cGMP synthesis in brain hemispheres and cerebellum during reperfusion after transient forebrain ischemia in gerbils: effect of 7-nitroindazole. J Neurosci Res 1998;54:681-690.
7. Jander S, Schroeter M, Stoll G: Role of NMDA receptor signalling in the regulation of inflammatory gene expression after focal brain ischemia. J Neuroimmunol 2000;109:181-187.
8. Dalkara T, Endres M, Moskowitz MA: Mechanisms of NO neurotoxicity. Prog Brain Res 1998;118:231-239.
9. Mies G, Kohno K, Hossmann K-A: MK-801, a glutamate antagonist, lowers flow threshold for inhibition of protein synthesis after middle cerebral artery occlusion of rat. Neurosci Lett 1993;155:65-68.
10. L is protective after middle cerebral artery occlusion in mice. Ann Neurol 2002;52:617-622.
11. Wang Y, Kilic E, Kilic U, Weber B, Bassetti CL, Marti HH, Hermann DM: VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena. Brain 2005;128:52-63.
12. Hermann DM, Kilic E, Kügler S, Isenmann S, Bähr M: Adenovirus-mediated GDNF and CNTF pretreatment protects against striatal injury following transient middle cerebral artery occlusion in mice. Neurobiol Dis 2001;8: 655-666.
13. Busch E, Krüger K, Allegrini PR, Kerskens CM, Gyngell ML, Hoelm-Berlage M, Hossmann K-A: Reperfusion after thrombolytic therapy of embolic stroke in the rat: magnetic resonance and biochemical imaging. J Cereb Blood Flow Metab 1998;18:407-418.
14. Kilic E, Hermann DM, Hossmann K-A: Recombinant tissue-plasminogen activator-induced thrombolysis after cerebral thromboembolism in mice. Acta Neuropathol (Berl) 2000; 99:219-222.
15. Rogove AD, Siao C, Keyt B, Strickland S, Tsirka SE: Activation of microglia reveals a non-proteolytic cytokine function for tissue plasminogen activator in the central nervous system. J Cell Sci 1999;112:4007-4016.
16. Harder JA, Aboobaker AA, Hodgetts TC, Ridley RM: Learning impairments induced by glutamate blockade using dizocilpine (MK-801) in monkeys. Br J Pharmacol 1998;125:1013-1018.
17. Le DA, Lipton SA: Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging. Drugs Aging 2001;18:717-724.