(09) Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo

Chemico-Biological Interactions

Volumn 157-158, Issue , 2005, Pages 367-368

  Kuca, Kamil ^a   Bartosova, Lucie ^a   Kassa, Jiri ^a   Cabal, Jiri ^a   Bajgar, Jiri ^a   Kunesova, Gabriela ^a   Jun, Daniel ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Acetylcholinesterase; Cyclosarin; Oxime; Reactivator; Tabun

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; ATROPINE; CYCLOSARIN; KO 27; KO 33; KO 48; OBIDOXIME; OXIME DERIVATIVE; PRALIDOXIME; TABUN; UNCLASSIFIED DRUG; CHOLINESTERASE INHIBITOR; NEUROTOXIN; OXIME;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; ENZYME INHIBITION; ENZYME REACTIVATION; GAS POISONING; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; RAT; ARTICLE; COMPARATIVE STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; NERVE CELL;

ANIMALIA;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; ENZYME ACTIVATION; NEURONS; NEUROTOXINS; OXIMES;

EID: 28744449392     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2005.10.054     Document Type: Conference Paper

References (6)

1. J. Bajgar Organophosphates/nerve agents poisoning: mechanism of action, diagnosis, prophylaxis and treatment Adv. Clin. Chem. 38 2004 151 216
2. K. Kuca, and J. Cabal In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes-K027, K005, K033 a K048 Centr. Eur. J. Publ. Health. 12 2004 S59 S61
3. K. Kuca, and J. Kassa A comparison of the ability of a new bispyridinium oxime-1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods J. Enzyme Inhib. Med. Chem. 18 2003 529 535
4. L. Sevelova, K. Kuca, and G. Krejcova Antidotal treatment of GF-agent intoxication in mice with new bispyridinium oximes Toxicology 207 2005 1 6
5. J. Cabal, K. Kuca, and J. Kassa Specification of the structure of oximes able to reactivate tabun inhibited acetylcholinesterase Pharmacol. Toxicol. 95 2004 81 86
6. K. Kuca, L. Sevelova-Bartosova, and G. Krejcova-Kunesova In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 and K048 Acta Med. (Hradec Kralove) 47 2004 107 109