In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 and K048

Central European Journal of Public Health

Volumn 12, Issue SUPPL., 2004, Pages

  Kuca K ^a   Cabal, J ^a  

^a Institute of Radiobiology and Immunology   (Czech Republic)

Author keywords

Acetylcholinesterase; Nerve agents; Oximes; Reactivation

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 HYDROXYIMINOMETHYLPYRIDINIUM) 3 (4 CARBAMOYLPYRIDINIUM)PROPANE DIBROMIDE; 1 (4 HYDROXYIMINOMETHYLPYRIDINIUM) 4 (4 CARBAMOYLPYRIDINIUM)BUTANE DIBROMIDE; 1,3 BIS(2 HYDROXYIMINOMETHYLPYRIDINIUM)PROPANE DIBROMIDE; 1,4 BIS(2 HYDROXYIMINOMETHYLPYRIDINIUM)BUTANE DIBROMIDE; CHOLINESTERASE REACTIVATOR; K 005; K 027; K 033; K 048; OBIDOXIME; OXIME DERIVATIVE; PRALIDOXIME; TABUN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; CHOLINESTERASE INHIBITION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; ENZYME ACTIVE SITE; ENZYME REACTIVATION; IN VITRO STUDY; KINETICS; NEUROTOXICITY; NONHUMAN; RAT;

ANIMALS; BRAIN; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; OXIMES; PHOSPHORIC ACID ESTERS; PYRIDINIUM COMPOUNDS; RATS;

EID: 2342636418     PISSN: 12107778     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (10)

1. Kassa J: Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol Clin Toxicol 2002; 40: 803-816.
2. Krejčová G, Kassa J: Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats. Toxicology 2003; 185: 129-139.
3. Marrs TC: Organophosphate poisoning. Pharmacol Therap 1993; 58: 51-66.
4. Kuča K, Kassa J: A comparison of the ability of a new byspyridinium oxime - 1-(hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods. J Enz Inhib 2003 (In press).
5. Kuča K, Bielavský J, Cabal J, Bielavská J: Synthesis of a potential reactivator of acetylcholinesterase 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)-propane dibromide. Tetrahedron Lett 2003; 44: 3123-3125.
6. Kuča K, Bielavský J, Cabal J, Kassa J: Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase. Bioorg Med Chem Lett 2003; 13: 3545-3548.
7. Kuča K, Cabal J: In vitro comparison of the reactivation effectivity of the potential symmetric bisquaternary acetylcholinesterase reactivators differing in the length of the connecting chain Voj Zdrav Listy 2003 (in press).
8. Koplovitz I, Stewart JR: A comparison of the efficacy of HI-6 and 2-PAM against soman, tabun, sarin and VX in the rabbit. Toxicol Lett 1994; 70: 169-179.
9. Kassa J, Cabal J: A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with presently used oximes and H oximes against sarin by in vitro and in vivo methods. Human Exp Toxicol 1999; 18: 560-565.
10. Kuča K, Patočka J, Cabal J: Reactivation of organophosphate inhibited acetylcholinesterase activity by α,ω -bis-(4-hydroxyiminomethylpyridinium)alkanes in vitro. J Appl Biomed 2003 (in press).