Immunosuppressive effect of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through the inhibition of T-lymphocyte proliferation and IL-2 production

Toxicology

Volumn 217, Issue 1, 2006, Pages 31-38

  Yun, Cheol Heui ^a   Son, Chang Gue ^b   Jung, Uhee ^c   Han, Seung Hyun ^a  

^a International Vaccine Institute   (South Korea)

^b Daejeon University   (South Korea)

^c Korea Atomic Energy Research Institute   (South Korea)

Author keywords

2 Amino 1 methyl 6 phenylimidazo 4,5 b pyridine; Heterocyclic amines; Interleukin 2; Reactive oxygen species

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; DNA; IMMUNOGLOBULIN KAPPA CHAIN; INTERLEUKIN 2; MESSENGER RNA; NUCLEAR FACTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHYTOHEMAGGLUTININ; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL ISOLATION; CELL LINE; CELL STIMULATION; CYTOKINE PRODUCTION; DNA BINDING; DOWN REGULATION; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MESSENGER RNA SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THYMOCYTE; TRANSCRIPTION INITIATION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; IMIDAZOLES; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; MICE; MICE, INBRED BALB C; MITOGENS; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; PHYTOHEMAGGLUTININS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA; MURINAE;

EID: 28744436742     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.08.011     Document Type: Article

References (42)

1. R.H. Adamson, U.P. Thorgeirsson, and T. Sugimura Extrapolation of heterocyclic amine carcinogenesis data from rodents and nonhuman primates to humans Arch. Toxicol. Suppl. 18 1996 303 318
2. A.T. Christian A cytogenetic footprint for mammary carcinomas induced by PhIP in rats Toxicology 181/182 2002 95 97
3. G.R. Crabtree, and N.A. Clipstone Signal transmission between the plasma membrane and nucleus of T lymphocytes Annu. Rev. Biochem. 63 1994 1045 1083
4. K. Doi, H. Wanibuchi, E.I. Salim, K. Morimura, A. Kinoshita, S. Kudoh, K. Hirata, J. Yoshikawa, and S. Fukushima Lack of large intestinal carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine at low doses in rats initiated with azoxymethane Int. J. Cancer 115 2005 870 878
5. W.L. Farrar, J.L. Cleveland, S.K. Beckner, E. Bonvini, and S.W. Evans Biochemical and molecular events associated with interleukin 2 regulation of lymphocyte proliferation Immunol. Rev. 92 1986 49 65
6. J.S. Felton, M.G. Knize, N.H. Shen, B.D. Andresen, L.F. Bjeldanes, and F.T. Hatch Identification of the mutagens in cooked beef Environ. Health Perspect. 67 1986 17 24
7. W.E. Glaab, K.L. Kort, and T.R. Skopek Specificity of mutations induced by the food-associated heterocyclic amine 2-amino-1-methyl-6-phenylimidazo-[4,5- b]-pyridine in colon cancer cell lines defective in mismatch repair Cancer Res. 60 2000 4921 4925
8. N.J. Gooderham, H. Zhu, S. Lauber, A. Boyce, and S. Creton Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Mutat. Res. 506/507 2002 91 99
9. C.J. Grubbs, J.C. Peckham, and K.D. Cato Mammary carcinogenesis in rats in relation to age at time of N-nitroso-N-methylurea administration J. Natl. Cancer Inst. 70 1983 209 212
10. S.H. Han, S.S. Yea, Y.J. Jeon, K.H. Yang, and N.E. Kaminski Transforming growth factor-beta 1 (TGF-beta1) promotes IL-2 mRNA expression through the up-regulation of NF-kappaB, AP-1 and NF-AT in EL4 cells J. Pharmacol. Exp. Ther. 287 1998 1105 1112
11. Y. Ikeda, Y.M. Cho, S. Takahashi, M. Tang, M. Asamoto, K. Ogawa, and T. Shirai Equivocal impact of transplacental and lactational exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, on prostate and colon lesion development in F344 rats Cancer Lett. 224 2005 23 30
12. J. Jain, C. Loh, and A. Rao Transcriptional regulation of the IL-2 gene Curr. Opin. Immunol. 7 1995 333 342
13. J. Jain, P.G. McCaffrey, V.E. Valge-Archer, and A. Rao Nuclear factor of activated T cells contains Fos and Jun Nature 356 1992 801 804
14. E. Junn, K.N. Lee, H.R. Ju, S.H. Han, J.Y. Im, H.S. Kang, T.H. Lee, Y.S. Bae, K.S. Ha, Z.W. Lee, S.G. Rhee, and I. Choi Requirement of hydrogen peroxide generation in TGF-beta 1 signal transduction in human lung fibroblast cells: involvement of hydrogen peroxide and Ca2+ in TGF-beta 1-induced IL-6 expression J. Immunol. 165 2000 2190 2197
15. N.E. Kaminski, W.S. Koh, K.H. Yang, M. Lee, and F.K. Kessler Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism Biochem. Pharmacol. 48 1994 1899 1908
16. J.S. Kang, Y.J. Jeon, H.M. Kim, S.H. Han, and K.H. Yang Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide- stimulated macrophages J. Pharmacol. Exp. Ther. 302 2002 138 144
17. M.G. Knize, K.S. Kulp, C.P. Salmon, G.A. Keating, and J.S. Felton Factors affecting human heterocyclic amine intake and the metabolism of PhIP Mutat. Res. 506/507 2002 153 162
18. M.A. Malfatti, R.W. Wu, and J.S. Felton The effect of UDP-glucuronosyltransferase 1A1 expression on the mutagenicity and metabolism of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in CHO cells Mutat. Res. 570 2005 205 214
19. Y. Minami, and T. Taniguchi IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor Curr. Opin. Cell. Biol. 7 1995 156 162
20. H.J. Moonen, J.J. Briede, J.M. van Maanen, J.C. Kleinjans, and T.M. de Kok Generation of free radicals and induction of DNA adducts by activation of heterocyclic aromatic amines via different metabolic pathways in vitro Mol. Carcinog. 35 2002 196 203
21. H.J. Moonen, Y.E. Dommels, M. van Zwam, M.H. van Herwijnen, J.C. Kleinjans, G.M. Alink, and T.M. de Kok Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells Mol. Carcinog. 40 2004 180 188
22. A.E. Norrish, L.R. Ferguson, M.G. Knize, J.S. Felton, S.J. Sharpe, and R.T. Jackson Heterocyclic amine content of cooked meat and risk of prostate cancer J. Natl. Cancer Inst. 91 1999 2038 2044
23. J.P. Northrop, K.S. Ullman, and G.R. Crabtree Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex J. Biol. Chem. 268 1993 2917 2923
24. S.A. Nowell, J. Ahn, and C.B. Ambrosone Gene-nutrient interactions in cancer etiology Nutr. Rev. 62 2004 427 438
25. B.L. Pool-Zobel, and U. Leucht Induction of DNA damage by risk factors of colon cancer in human colon cells derived from biopsies Mutat. Res. 375 1997 105 115
26. S.J. Roberts-Thomson, and E.G. Snyderwine Characterization of peroxisome proliferator-activated receptor alpha in normal rat mammary gland and 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary gland tumors from rats fed high and low fat diets Toxicol. Lett. 118 2000 79 86
27. C.K. Sen, and L. Packer Antioxidant and redox regulation of gene transcription FASEB J. 10 1996 709 720
28. L. Shan, M. Yu, H.A. Schut, and E.G. Snyderwine Susceptibility of rats to mammary gland carcinogenesis by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) varies with age and is associated with the induction of differential gene expression Am. J. Pathol. 165 2004 191 202
29. T. Shirai, M. Asamoto, S. Takahashi, and K. Imaida Diet and prostate cancer Toxicology 181/182 2002 89 94
30. T. Shirai, L. Cui, S. Takahashi, M. Futakuchi, M. Asamoto, K. Kato, and N. Ito Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate Cancer Lett. 143 1999 217 221
31. T. Shirai, S. Takahashi, L. Cui, M. Futakuchi, K. Kato, S. Tamano, and K. Imaida Experimental prostate carcinogenesis-rodent models Mutat. Res. 462 2000 219 226
32. R. Sinha An epidemiologic approach to studying heterocyclic amines Mutat. Res. 506/507 2002 197 204
33. K.A. Smith Interleukin-2: inception, impact, and implications Science 240 1988 1169 1176
34. I.K. Sorensen, A. Mortensen, E. Kristiansen, C. van Kreijl, R.H. Adamson, and S.S. Thorgeirsson Short-term carcinogenicity testing of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3- methylimidazo[4,5-f]quinoline (IQ) in E(mu)-pim-1 transgenic mice Carcinogenesis 17 1996 2221 2227
35. I.L. Steffensen, J.E. Paulsen, T.J. Eide, and J. Alexander 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine increases the numbers of tumors, cystic crypts and aberrant crypt foci in multiple intestinal neoplasia mice Carcinogenesis 18 1997 1049 1054
36. T. Sugimura Overview of carcinogenic heterocyclic amines Mutat. Res. 376 1997 211 219
37. H.J. Thompson, H. Adlakha, and M. Singh Effect of carcinogen dose and age at administration on induction of mammary carcinogenesis by 1-methyl-1-nitrosourea Carcinogenesis 13 1992 1535 1539
38. M. Torres, and H.J. Forman Redox signaling and the MAP kinase pathways Biofactors 17 2003 287 296
39. Y. Totsuka, K. Fukutome, M. Takahashi, S. Takahashi, A. Tada, T. Sugimura, and K. Wakabayashi Presence of N2-(deoxyguanosin-8-yl)-2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues Carcinogenesis 17 1996 1029 1034
40. K. Wakabayashi, Y. Totsuka, K. Fukutome, A. Oguri, H. Ushiyama, and T. Sugimura Human exposure to mutagenic/carcinogenic heterocyclic amines and comutagenic beta-carbolines Mutat. Res. 376 1997 253 259
41. K.H. Yang, B.S. Kim, A.E. Munson, and M.P. Holsapple Immunosuppression induced by chemicals requiring metabolic activation in mixed cultures of rat hepatocytes and murine splenocytes Toxicol. Appl. Pharmacol. 83 1986 420 429
42. M. Yu, M.L. Jones, M. Gong, R. Sinha, H.A. Schut, and E.G. Snyderwine Mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mammary gland of Big Blue rats on high-and low-fat diets Carcinogenesis 23 2002 877 884