Plasma homocysteine and markers of bone metabolism in psychogeriatric patients

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 65, Issue 8, 2005, Pages 671-680

  Nilsson, K ^a   Gustafson, L ^a   Isaksson, A ^a   Hultberg, B ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alkaline phosphatase; Bone metabolism; Cobalamin; Crosslaps; Cystatin C; Folate; Homocysteine; Osteocalcin

Indexed keywords

COBALAMIN; FOLIC ACID; HOMOCYSTEINE; OSTEOCALCIN;

AGED; ARTICLE; BONE METABOLISM; COMPARATIVE STUDY; CONTROLLED STUDY; DEMENTIA; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; FOLIC ACID BLOOD LEVEL; FRAGILITY FRACTURE; GERIATRIC PATIENT; HORMONE BLOOD LEVEL; HUMAN; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; MULTIPLE REGRESSION; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; RISK FACTOR; SAMPLE SIZE; VITAMIN BLOOD LEVEL;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BONE AND BONES; DEMENTIA; FEMALE; HOMOCYSTEINE; HUMANS; MALE; MENTAL DISORDERS; MIDDLE AGED; OSTEOCALCIN; SEX CHARACTERISTICS;

EID: 28744436696     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510500348153     Document Type: Article

References (21)

1. Nilsson K, Gustafson L, Fäldt R, Andersson A, Brattström L, Lindgren A, et al. Hyperhomocysteinemia: a common finding in a psychogeriatric population. Eur J Clin Invest 1996;26:853-9.
2. Nilsson K, Gustafson L, Hultberg B. Plasma homocysteine is a sensitive marker for tissue deficiency of both cobalamins and folates in a psychogeriatric population. Dementia 1999;10:476-82.
3. Nilsson K, Gustafson L, Hultberg B. The plasma homocysteine concentration is better than that of serum methylmalonic acid as a marker for sociopsychological performance in a psychogeriatric population. Clin Chem 2000;46:691-6.
4. Nilsson K, Gustafson L, Isaksson A, Hultberg B. Folate deficiency is a common finding in psychogeriatric patients. Aging Clin Exp Res 2002;14:479-84.
5. Nilsson K, Gustafson L, Hultberg B. Role of impaired renal function as a cause of elevated plasma homocysteine concentration in psychogeriatric patients. Scand J Clin Lab Invest 2002;62:385-90.
6. van Meurs JBJ, Dhonukshe-Rutten RAM, Pluijm SMF, van der Klift M, de Jonge R, Lindemans J, et al. Homocysteine levels and risk of osteoporotic fracture. N Engl J Med 2004;350:2033-41.
7. McLean RR, Jacques PF, Selhub J, Tucker K, Samelson EJ, Broe KE, et al. Homocysteine as a predictive factor for hip fractures in older persons. N Engl J Med 2004;350:2042-9.
8. Raisz LG. Homocysteine and osteoporotic fractures: culprit or bystanders. N Engl J Med 2004;350:2089-90.
9. Lubec B, Fang-Kircher S, Lubec T, Blom HJ, Boers GHJ. Evidence for McKusicks's hypothesis of deficient collagen cross-linking in patients with homocystinuria. Biochim Biophys Acta 1996;1315:159-62.
10. Delmas PD, Eastell R, Garnero P, Seibel MJ, Stepan J. The use of biochemical markers of bone turnover in osteoporosis. Osteoporos Int 2000;Suppl 6:S2-17.
11. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999;56:303-8.
12. Nilsson K, Gustafson L, Fäldt R, Andersson A, Hultberg B. Plasma homocysteine in relation to serum cobalamin and blood folate in a psychogeriatric population. Eur J Clin Invest 1994;24:600-6.
13. Nilsson K, Gustafson L, Fäldt R, Andersson A, Vaara I, Nilsson R, et al. Plasma methylmalonic acid in relation to serum cobalamin and plasma homocysteine in a psychogeriatric population and the effect of cobalamin treatment. Int J Ger Psych 1997;12:62-72.
14. Andersson A, Isaksson A, Brattström L, Hultberg B. Homocysteine and other thiols determined in plasma by HPLC and thiol-specific post-column derivatization. Clin Chem 1993;39:1590-7.
15. Mudd SH, Levy HL, Skovby F. Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, , Valle D, editors, . The metabolic and molecular basis of inherited disease. 7th ed. New York: McGraw-Hill Book Co.; 1995. pp 1279-327.
16. 12 to bone mineral density of postmenopausal women. Bone 2003;33:956-9.
17. Dhonukse-Rutten RAM, van Dusseldorp M, Schneede J, deGroot LCPGM, van Staveren WA. Low bone mineral density and bone mineral content are associated with low cobalamin status in adolescents. Eur J Nutr 2004; published online, 30 August.
18. 12 is associated with lower BMD: the Framingham osteoporosis study. J Bone Min Res 2005;20:152-158.
19. Sato Y, Honda Y, Iwamoto T, Kanoko T, Satoh K. Effect of folate and mecobalamin on hip fracture in patients with stroke. JAMA 2005;293:1082-8.
20. Abrahamsen B, Madsen JS, Tofteng CL, Stilgren L, Bladbjerg EM, Kristensen SR, et al. Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food record from the Danish osteoporosis prevention study. Bone 2005;36:577-83.
21. Jacobson SH. The reaction of homocysteine with aldehyde: an explanation of the collagen defects in homocystinuria. Clin Chim Acta 1973;45:215-7.