A convenient synthesis by microwave irradiation of an active metabolite (EXP-3174) of losartan

Tetrahedron Letters

Volumn 44, Issue 6, 2003, Pages 1149-1152

  Santagada, Vincenzo ^a   Fiorino, Ferdinando ^a   Perissutti, Elisa ^a   Severino, Beatrice ^a   Terracciano, Sara ^a   Teixeira, Cleber Evandro ^b   Caliendo, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

EXP 3174; Microwave irradiation in solution; Synthesis of losartan metabolite

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; CHEMICAL COMPOUND; IMIDAZOLE DERIVATIVE; LOSARTAN;

ARTICLE; CHEMICAL REACTION; COMPARATIVE STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITE; MICROWAVE IRRADIATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; SYNTHESIS;

EID: 0037415536     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)02835-6     Document Type: Article

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18. 6): δ 7.69 (d, 1H, J=8 Hz), δ 7.66 (t, 1H, J=8 Hz), δ 7.59 (t, 1H, J=8 Hz), δ 7.53 (d, 1H, J=8 Hz), δ 7.08 (d, 2H, J=8.5 Hz), δ 6.97 (d, 2H, J=8.5 Hz), δ 5.60 (s, 2H), δ 2.58 (t, 2H, J=7 Hz), δ 1.53 (quint, 2H, J=7 Hz), δ 1.24 (sext, 2H, J=7 Hz), δ 0.82 (t, 3H, J=7 Hz).
19. 6): δ 9.68 (s, 1H), δ 7.68 (d, 1H, J=8 Hz), δ 7.65 (t, 1H, J=8 Hz), δ 7.58 (t, 1H, J=8 Hz), δ 7.52 (d, 1H, J=8 Hz), δ 7.10 (d, 2H, J=8.5 Hz), δ 7.03 (d, 2H, J=8.5 Hz), δ 5.58 (s, 2H), δ 2.63 (t, 2H, J=7 Hz), δ 1.51 (quint, 2H, J=7 Hz), δ 1.26 (sext, 2H, J=7 Hz), δ 0.81 (t, 3H, J=7 Hz).
20. 2. Under a resting tension of 10 mN, isometric tension changes were recorded on a Power Lab 400™ data acquisition system (software Chart, version 4.0, AD Instruments, MA, USA), through force-displacement transducers (Ugo Basile, Varese, Italy). After equilibration for 1 h, a single contractile-response curve to the cumulative addition of angiotensin II (100 pM-30 nM) was constructed. The strips were then washed and allowed to relax to the baseline tension. Each strip was then incubated for 30 min with a single concentration of compound (EXP-3174 or aldehyde derivative) before a second contractile-response curve to angiotensin II was obtained.
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