Pharmacologic agents in fracture healing

Clinics in Sports Medicine

Volumn 25, Issue 1, 2006, Pages 63-73

  Koester, Michael C ^a   Spindler, Kurt P ^a  

^a Medical Center East   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; BONE MORPHOGENETIC PROTEIN; CALCIUM; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; INDOMETACIN; KETOROLAC; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PAMIDRONIC ACID; PARATHYROID HORMONE; PARATHYROID HORMONE[1-34]; RISEDRONIC ACID; ROFECOXIB; TRANSFORMING GROWTH FACTOR BETA2; VALDECOXIB; VITAMIN D;

ACETABULUM FRACTURE; ATHLETE; BONE REMODELING; BONE TURNOVER; CLINICAL TRIAL; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; DRUG WITHDRAWAL; FRACTURE FIXATION; FRACTURE HEALING; FRACTURE NONUNION; HETEROTOPIC OSSIFICATION; HUMAN; HUMERUS FRACTURE; LOW DRUG DOSE; NONHUMAN; OSTEOPOROSIS; POSTOPERATIVE PAIN; PSEUDARTHROSIS; RADIUS FRACTURE; REVIEW; SIDE EFFECT; STRESS FRACTURE; TIBIA FRACTURE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ATHLETIC INJURIES; BONE DENSITY; BONE REGENERATION; CALCIUM; DIETARY SUPPLEMENTS; DIPHOSPHONATES; FEMALE; FRACTURES, BONE; HUMANS; MALE; PARATHYROID HORMONE; SPORTS MEDICINE; VITAMIN D;

EID: 28544446921     PISSN: 02785919     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.csm.2005.08.004     Document Type: Review

References (54)

1. S.L. Hame, J.M. LaFemina, and D.R. McAllister Fractures in the collegiate athlete Am J Sports Med 32 2004 446 451
2. P. Adolphson, H. Abbaszadegan, and H. Boden Clodronate increases mineralization of callus after Colles' fracture: a randomized, double-blind, placebo-controlled, prospective trial in 32 patients Acta Orthop Scand 71 2000 195 200
3. E. van der Poest Clement, P. Patka, K. Vandormael, and H. Haarman The effect of alendronate on bone mass after distal forearm fracture J Bone Miner Res 15 2000 586 593
4. H. Fleisch Can bisphosphonates be given to patients with fractures? J Bone Miner Res 16 2001 437 440
5. C. Li, S. Mori, and J. Li Long-term effect of incadronate disodium (YM-175) on fracture healing of femoral shaft in growing rats J Bone Miner Res 16 2001 429 436
6. D.B. Burr Pharmaceutical treatments that may prevent or delay the onset of stress fractures D.B. Burr C. Milgrom Musculoskeletal fatigue and stress fractures 2001 CRC Press Boca Raton (FL) 259 270
7. C. Milgrom, A. Finestone, and V. Novack The effect of prophylactic treatment with risedronate on stress fracture incidence among infantry recruits Bone 35 2004 418 424
8. G.W. Stewart, M.E. Brunet, and M. Manning Treatment of stress fractures in athletes with intravenous pamidronate Clin J Sport Med 15 2005 92 94
9. N. Patlas, G. Golomb, and P. Yaffe Transplacental effects bisphosphonates on fetal skeleton ossification and mineralization in rats Teratology 60 1999 68 73
10. A.D. Geddes, S.M. D'Souza, and F.H. Ebetino Bisphosphonates structure-activity relationships and therapeutic implications J Bone Miner Res 8 1994 265 306
11. D.H. Minsker, J.M. Manson, and C.P. Peter Effects of the bisphosphonate, alendronate, on parturition in rats Toxicol Appl Pharmacol 121 1993 217 223
12. R. Skripitz, and P. Aspenburg Parathyroid hormone: a drug for orthopaedic surgery? Acta Orthop Scand 75 2004 654 662
13. H. Selye On the stimulation of new bone-formation with parathyroid extract and irradiated ergosterol Endocrinology 16 1932 547 548
14. H. Dobnig, and R.T. Turner Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells Endocrinology 136 1995 3632 3638
15. H. Qi, M. Li, and T.J. Wronski A comparison of the anabolic effects of parathyroid hormone at skeletal sites with moderate and severe osteopenia in aged ovariectomized rats J Bone Miner Res 10 1995 948 955
16. R.L. Jilka, R.S. Weinstein, and T. Bellido Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone J Clin Invest 104 1999 439 446
17. T. Bellido, A.A. Ali, and L.I. Plotkin Proteasomal degradation of Runx2 shortens PTH-induced anti-apoptotic signaling in osteoblasts: a putative explanation for why intermittent administration is needed for bone anabolism J Biol Chem 278 2003 50259 50272
18. H.M. Frost, and W.S. Jee On the rat model of human osteopenias and osteoporoses Bone Miner 18 1992 227 236
19. A.B. Hodsman, L.J. Fraher, and P.H. Watson A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone versus cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis J Clin Endocrinol Metab 82 1997 620 628
20. F. Cosman, and R. Lindsay Is parathyroid hormone a therapeutic option for osteoporosis? A review of the clinical evidence Calcif Tissue Int 62 1998 475 480
21. D.W. Dempster, F. Cosman, and E.S. Kurland Effect of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study J Bone Miner Res 16 2001 1846 1853
22. B.P. Halloran, D.D. Birkle, and J. Harris Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading J Bone Miner Res 12 1997 1068 1074
23. L. Zhang, H.E. Takahashi, and J. Inoue Effects of intermittent administration of low dose human PTH (1-34) on cancellous and cortical bone of lumbar vertebral bodies in adult beagles Bone 21 1997 501 506
24. T.T. Andreassen, C. Ejersted, and H. Oxlund Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures J Bone Miner Res 14 1999 960 968
25. R. Skripitz, T.T. Andreassen, and P. Aspenberg Strong effect of PTH (1-34) on regenerating bone: a time sequence study in rats Acta Orthop Scand 71 2000 619 624
26. G. Holzer, R.J. Majeska, and M.W. Lundy Parathyroid hormone enhances fracture healing: a preliminary report Clin Orthop 366 1999 258 263
27. A. Nakajima, N. Shimoji, and K. Shiomi Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34) J Bone Miner Res 17 2002 2038 2047
28. R.M. Neer, C.D. Arnaud, and J.R. Zanchetta Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis N Engl J Med 334 2001 1434 1441
29. J.J. Body, G.A. Gaich, and W.H. Scheele A randomized double-blind trial to compare the efficacy of teriparatide [recombinant human parathyroid hormone (1-34)] with alendronate in postmenopausal women with osteoporosis J Clin Endocrinol Metab 87 2002 4528 4535
30. H. Omeroglu, Y. Ates, and O. Akkus Biomechanical analysis of the effects of single high-dose vitamin D3 on fracture healing in a healthy rabbit model Arch Orthop Trauma Surg 116 1997 271 274
31. A.D. Delgado-Martinez, M.E. Martinez, and M.T. Carrascal Effect of 25-OH-vitamin D on fracture healing in elderly rats J Orthop Res 16 1998 650 653
32. P.F. Brumbaugh, D.P. Speer, and M.J. Pitt 1-alpha, 25-Dihydroxyvitamin D3 a metabolite of vitamin D that promotes bone repair Am J Pathol 106 1982 171 179
33. A.M. Doetsch, J. Faber, and N. Lynnerup The effect of calcium and vitamin D3 supplementation on the healing of the proximal humerus fracture: a randomized placebo-controlled study Calcif Tissue Int 75 2004 183 188
34. X. Zhang, E.M. Schwarz, and D.A. Young Cyclooxygenase-2 regulates mesenchymal cell differentiation into osteoblast lineage and is critically involved in bone repair J Clin Invest 109 2002 1405 1415
35. A.M. Simon, M.B. Manigrasso, and J.P. O'Connor Cyclo-oxygenase 2 function is essential for bone fracture healing J Bone Miner Res 17 2002 963 976
36. L. Gerstenfeld, M. Thiede, and K. Seibert Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 (COX2) selective non-steroidal anti-inflammatory drugs J Orthop Res 21 2003 67
37. K.M. Brown, M.M. Saunders, and T. Kirsch Effect of COX-2 specific inhibition on fracture-healing in the rat femur J Bone Joint Surg Am 86A 2004 116 123
38. H. Allen, A. Wase, and W. Bear Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat Acta Orthop Scand 51 1980 595 600
39. R.D. Altman, L.L. Latta, and R. Keer Effect of nonsteroidal anti-inflammatory drugs on fracture healing: a laboratory study in rats J Orthop Trauma 9 1995 392 400
40. M. Elves, I. Bayley, and P. Raylance The effect of indomethacin upon experimental fractures in the rat Acta Orthop Scand 53 1982 35 41
41. H. Hogevold, B. Grogaard, and O. Reikeras Effects of short-term treatment with corticosteroids and indomethacin on bone healing Acta Orthop Scand 63 1992 600 611
42. E. Suddmann, T. Tveita, and J. Hald Lack of effect of indomethacin on ordered growth of the femur in rats Acta Orthop Scand 53 1982 43 49
43. K. Bennell, and P. Brukner How should you treat a stress fracture? D. MacAuley T. Best Evidence based sports medicine volume 26 2002 BMJ Books London 491 517
44. P. Wheeler, and M.E. Batt Do non-steroidal anti-inflammatory drugs adversely affect stress fracture healing? A short review Br J Sports Med 39 2005 65 69
45. P. Adolphson, H. Abbaszadegan, and U. Jonsson No effects of piroxicam on osteopenia and recovery after Colles' fracture: a randomized, double-blind, placebo-controlled, prospective trial Arch Orthop Trauma Surg 112 1993 127 130
46. T. Bhattacharyya, R. Levin, and M.S. Vrahas Nonsteroidal anti-inflammatory drugs and nonunion of humeral shaft fractures Arthritis Rheum 53 3 2005 364 367
47. M. Bhandari, P. Tornetta, and S. Sprague Predictors of reoperation following operative management of fractures of the tibial shaft J Orthop Trauma 17 2003 353 361
48. T. Burd, M. Hughes, and J. Anglen Heterotopic ossification prophylaxis with indomethacin increases the risk of long-bone nonunion J Bone Joint Surg Br 85B 2003 700 705
49. M. Deguchi, A.J. Rapoff, and T.A. Zdeblick Posterolateral fusion for isthmic spondylolisthesis in adults: analysis of fusion rate and clinical results J Spinal Disord 11 1998 459 464
50. P.V. Giannoudis, D.A. MacDonald, and S.J. Matthews Nonunion of the femoral diaphysis: the influence of reaming and non-steroidal anti-inflammatory drugs J Bone Joint Surg Br 82B 2000 655 658
51. S.D. Glassman, S.M. Rose, and J.R. Dimar The effect of postoperative nonsteroidal anti-inflammatory drug administration on spinal fusion Spine 23 1998 834 838
52. S.S. Reuben, and E.F. Ekman The effect of cyclooxygenase-2 inhibition on analgesia and spinal fusion J Bone Joint Surg Am 87A 2005 536 542
53. S.S. Reuben, D. Ablett, and R. Kaye High dose nonsteroidal anti-inflammatory drugs compromise spinal fusion Can J Anaesth 52 2005 506 512
54. D. Mayer Sources of bias D. Mayer Essential evidence-based medicine 2004 Cambridge University Press Cambridge (UK) 74 86