Synthesis and antiplatelet activity of new imidazole-4-carboxylic acid derivatives

Archiv der Pharmazie

Volumn 338, Issue 11, 2005, Pages 539-547

  Rehse, Klaus ^a   Steege, Jens ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Adrenaline, ADP and PAF antagonism; Cox 1 inhibition; Imidazole 4 carboxamides; Imidazole 4 carboxylic acid esters; Inhibition of platelet aggregation

Indexed keywords

1 (4 CHLOROPHENYLMETHYL) 5 (4 CHLOROPHENYLSULFONYLAMINO) 1H IMIDAZOLE N (3 CYCLOHEXYLAMINOPROPYL) 4 CARBOXAMIDE; 5 (4 CHLOROPHENYLSULFONYLAMINO) 1 (3 PHENYLPROPYL) 1H IMIDAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 5 (4 CHLOROPHENYLSULFONYLAMINO) 1 (3 PHENYLPROPYL) 1H IMIDAZOLE N (3 CYCLOHEXYLAMINOPROPYL) 4 CARBOXAMIDE; ANTITHROMBOCYTIC AGENT; CARBOXYLIC ACID DERIVATIVE; CYCLOOXYGENASE 1 INHIBITOR; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; HYDROPHOBICITY; IC 50; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; BLOOD PLATELETS; CARBOXYLIC ACIDS; COLLAGEN; CYCLOOXYGENASE INHIBITORS; IMIDAZOLES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 28544436812     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200500150     Document Type: Article

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